GTP Cyclohydrolase 1 (GCH1) (C-Term) Peptid
GCH1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN977328
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für GTP Cyclohydrolase 1 (GCH1) (C-Term) Peptid (ABIN977328)
Target
GCH1
(GTP Cyclohydrolase 1 (GCH1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- LRPAGVGVVV EATHMCMVMR GVQKMNSKTV TSTMLGVFRE DPKTREEFLT
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-GCH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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GTP Cyclohydrolase 1 (GCH1) peptide
GCH1 Reaktivität: Human, Maus, Ratte Wirt: Synthetic BP, Imm
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GCH1 (GTP Cyclohydrolase 1 (GCH1))
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Hintergrund
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This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Alias Symbols: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Protein Interaction Partner: AHSA1,ATP1B1,GCH1,GCHFR,HSPA8,RAB26,RLF,RPH3A,OSBPL9,RPH3A
Protein Size: 250 -
Molekulargewicht
- 28 kDa
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Gen-ID
- 2643
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NCBI Accession
- NM_000161, NP_000152
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UniProt
- P30793
Target
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