GTP Cyclohydrolase 1 (GCH1) (C-Term) Peptid
Kurzübersicht für GTP Cyclohydrolase 1 (GCH1) (C-Term) Peptid (ABIN8102000)
Target
Spezies
Quelle
Applikation
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Protein Region
- C-Term
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Verwendungszweck
- GCH1 Peptide - C-terminal region
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Sequenz
- LRPAGVGVVV EATHMCMVMR GVQKMNSKTV TSTMLGVFRE DPKTREEFLT
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GTP Cyclohydrolase 1 (GCH1) peptide
GCH1 Reaktivität: Human, Maus, Ratte Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-GCH1 Antibody (ARP59618_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- GCH1 (GTP Cyclohydrolase 1 (GCH1))
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Hintergrund
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Background Information: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Alternative Symbols: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
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Molekulargewicht
- 28kDa
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Gen-ID
- 2643
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NCBI Accession
- NP_000152
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UniProt
- P30793
Target
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