Galanin Receptor 2 (GALR2) (C-Term) Peptid
GALR2
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle GALR2 Produkte
- GALR2 (Galanin Receptor 2 (GALR2))
- Protein Region
- C-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- RGTHSGSVLE RESSDLLHMS EAAGALRPCP GASQPCILEP CPGPSWQGPK
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-GALR2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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Galanin Receptor 2 (GALR2) peptide
GALR2 Reaktivität: Human, Rind (Kuh), Maus, Hund, Ratte Wirt: Synthetic BP, Imm
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GALR2 (Galanin Receptor 2 (GALR2))
- Hintergrund
-
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Alias Symbols: GALNR2, MGC125983, MGC125984
Protein Interaction Partner: GAL,GNAQ
Protein Size: 387 - Molekulargewicht
- 43 kDa
- Gen-ID
- 8811
- NCBI Accession
- NM_003857, NP_003848
- UniProt
- O43603
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