A synthetic peptide for use as a blocking control in assays to test for specificity of PARP11 antibody, Alternative Names: PARP11 control peptide, PARP11 antibody Blocking Peptide, Anti-PARP11 Blocking Peptide, Adp-Ribose Polymerase 11 Blocking Peptide, C12orf6 Blocking Peptide, DKFZp779H0122 Blocking Peptide, Poly (ADP-ribose) polymerase 11 Blocking Peptide, PARP11, PARP-11, PARP 11, PARP-11 Blocking Peptide, PARP 11 Blocking Peptide
Optimal conditions should be determined by the investigator
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Handhabung
Avoid repeated freeze/thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20 °C long term.
Target
PARP11
(Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))
Synonyme
5330431N24Rik Peptide, AI851877 Peptide, ARTD11 Peptide, HIN1L Peptide, C12orf6 Peptide, parp11 Peptide, MGC82612 Peptide, PARP11 Peptide, RGD1561791 Peptide, poly (ADP-ribose) polymerase family, member 11 Peptide, poly(ADP-ribose) polymerase family member 11 Peptide, poly(ADP-ribose) polymerase family member 11 S homeolog Peptide, poly(ADP-ribose) polymerase family member 11 L homeolog Peptide, Parp11 Peptide, PARP11 Peptide, parp11.S Peptide, parp11.L Peptide, parp11 Peptide
Hintergrund
PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.