A synthetic peptide for use as a blocking control in assays to test for specificity of DNTT antibody, Alternative Names: DNTT control peptide, DNTT antibody Blocking Peptide, Anti-DNTT Blocking Peptide, Deoxynucleotidyltransferase Terminal Blocking Peptide, TDT Blocking Peptide
DNTT is a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor geneegments.