Deoxynucleotidyltransferase, terminal (DNTT) (Middle Region) Peptid
Kurzübersicht für Deoxynucleotidyltransferase, terminal (DNTT) (Middle Region) Peptid (ABIN8098788)
Target
Quelle
Applikation
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Protein Region
- Middle Region
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Verwendungszweck
- DNTT Peptide - middle region
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-DNTT antibody ( ARP52032_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
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Hintergrund
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Background Information: DNTT is the template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Alternative Symbols: TDT
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Molekulargewicht
- 58kDa
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Gen-ID
- 1791
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NCBI Accession
- NP_004079
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UniProt
- P04053
Target
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