A synthetic peptide for use as a blocking control in assays to test for specificity of SF3 B1 antibody, Alternative Names: SF3B1 control peptide, SF3B1 antibody Blocking Peptide, Anti-SF3B1 Blocking Peptide, Splicing Factor 3B Subunit 1 155Kda Blocking Peptide, SF3B1, SFB1-3, SFB1 3, SFB1-3 Blocking Peptide, SFB1 3 Blocking Peptide
SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.