A synthetic peptide for use as a blocking control in assays to test for specificity of EPOR antibody, Alternative Names: EPOr control peptide, EPOr antibody Blocking Peptide, Anti-EPOr Blocking Peptide, Erythropoietin Receptor Blocking Peptide, MGC138358 Blocking Peptide
Aufreinigung
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.