3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) Peptid
PDPK1
Reaktivität: Maus
Wirt: Synthetic
BP, WB
Produktnummer ABIN5671403
Kurzübersicht für 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (Middle Region) Peptid (ABIN5671403)
Target
PDPK1
(3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
Spezies
Maus
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- QYFLDRFYMS RISIRMLLNQ HSLLFGGKGS PSHRKHIGSI NPNCDVVEVI
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- PDK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) peptide
PDPK1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
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Hintergrund
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Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity).
Alias Symbols: B830012B01, D530020C15Rik
Protein Size: 434 -
Gen-ID
- 228026
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NCBI Accession
- NM_172665, NP_766253
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UniProt
- Q8BFP9
Target
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