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helicase 2, X-linked (ATRX) (C-Term) Peptid

ATRX Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN5513605
  • Target Alle ATRX Produkte
    ATRX (helicase 2, X-linked (ATRX))
    Protein Region
    C-Term
    Spezies
    Human
    Quelle
    • 2
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-ATRX Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    ATRX (helicase 2, X-linked (ATRX))
    Hintergrund
    The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

    Protein Size: 1350
    Gen-ID
    546
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