Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (C-Term) Peptid
TDP1
Reaktivität: Maus, Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN2185631
Kurzübersicht für Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (C-Term) Peptid (ABIN2185631)
Target
TDP1
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
Spezies
Maus, Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- C-Term
-
Sequenz
- GRPPGKSAVP LHLIYPSVEN VRTSLEGYPA GGSLPYSIQT AEKQRWLHSY
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Tdp1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeat freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
-
Hintergrund
-
Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue and Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Tdp1 acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It Has low h3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups and has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Protein Size: 609 -
Molekulargewicht
- 66 kDa
-
UniProt
- Q8BJ37
Target
-
Sie sind hier:
