A synthetic peptide for use as a blocking control in assays to test for specificity of Tdp1 antibody, Alternative Names: Tdp1 control peptide, Tdp1 antibody Blocking Peptide, Anti-Tdp1 Blocking Peptide, tyrosyl-DNA phosphodiesterase 1 Blocking Peptide, 2810481F14Rik Blocking Peptide, 4921509N21Rik Blocking Peptide, AI838772 Blocking Peptide, AW493413 Blocking Peptide, E430034L06Rik Blocking Peptide, SCAN1 Blocking Peptide, Tdp1, Tdp-1, Tdp 1, Tdp-1 Blocking Peptide, Tdp 1 Blocking Peptide
Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.