GTP Cyclohydrolase 1 (GCH1) (N-Term) Peptid
GCH1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN2185568
Kurzübersicht für GTP Cyclohydrolase 1 (GCH1) (N-Term) Peptid (ABIN2185568)
Target
GCH1
(GTP Cyclohydrolase 1 (GCH1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- N-Term
-
Sequenz
- PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-GCH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
GTP Cyclohydrolase 1 (GCH1) peptide
GCH1 Reaktivität: Human, Maus, Ratte Wirt: Synthetic BP, Imm
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeat freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- GCH1 (GTP Cyclohydrolase 1 (GCH1))
-
Hintergrund
-
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Protein Size: 250 -
Molekulargewicht
- 27 kDa
-
Gen-ID
- 2643
-
UniProt
- P30793
Target
-
Sie sind hier:
