anti-CDX2 (CDX2) Antikörper

Rhesus Monkey Caudal Type Homeobox 2 (CDX2) Interaktionspartner

1. These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.

Human Caudal Type Homeobox 2 (CDX2) Interaktionspartner

1. Low CDX2 expression is associated with colorectal cancer.

2. we have identified a promoter region in the YAP1 gene with importance for the transcriptional activation of YAP1 in all tested cell lines. Furthermore, we identified a YAP1 +82 kb enhancer with functional CDX2 and HNF4alpha binding sites that increases YAP1 promoter activity in Caco-2 and T84 cells.

3. Data suggest that a low caudal type homeo box transcription factor 2 protein (CDX2) expression may be prognostic in microsatellite stable (MSS) colorectal tumours with a high stromal content.

4. Down-regulation of LINC00518 might have the ability to suppress Breast cancer progression by up-regulating CDX2 expression through the reduction of methylation and blockade of the Wnt signaling pathway, resulting in the inhibition of proliferation and promotion of apoptosis of BC epithelial cells.

5. CDX2 has a dual function in regulating both ST14 and SPINT1, gene expression in intestinal cells. We find that CDX2 is not required for the basal ST14 and SPINT1 gene expression; however changes in CDX2 expression affects the ST14/SPINT1 mRNA ratio.

6. retrospective study provides validation regarding the prognostic impact of CDX2 in patients with stage II colon cancer

7. Dual-positive expression of SATB2 and CDX2 both show higher specificity in identifying signet ring cell carcinomas of lower GI tract origin.

8. Loss of CDX2 in colorectal cancer is an adverse prognostic biomarker only in stage IV disease and appears to be associated with benefit from adjuvant chemotherapy in stage III.

9. Study shows that CDX2 in colorectal cancer (CRC) can be regulated by either promoter methylation and more markedly by histone acetylation. CDX2 loss is an adverse prognostic factor and linked to molecular features of the serrated pathway.

10. CDX2 immunoreactivity is common, whereas TTF-1 expression is rare in oropharyngeal undifferentiated carcinomas.

11. Intestine-specific transcription factor CDX2 was identified as a potential marker of recurrence as it was exclusively upregulated in colorectal adenomas with recurrence.

12. Nuclear beta-catenin and CDX2 expression individually or in combination are validated prognostic markers for ovarian endometrioid carcinoma

13. human colon cancers exhibiting the highest reduction in CDX2 expression belong to the serrated subtype with the worst evolution.

14. CDX2 positivity is confirmed to be a strong prognostic determinant associated with an excellent survival in stage II and III CRC in this meta-analysis, the largest ever conducted, to our knowledge

15. This review discusses the role of aberrant expression of CDX2 in the prognosis and the response to treatment in patients with different leukemia in clinical reports in the recent decades.

16. Findings suggest that caudal type homeo box transcription factor 2 protein (CDX2) plays an important role in the process of early embryonic development.

17. Study aimed to explain Cdx-2 variant association with immune-related conditions. Authors hypothesised that the effect of Cdx-2 polymorphism on VDR expression in monocytes/macrophages, devoid of the CDX-2 TF, is indirect and dependent on circulating 25(OH)D3 and VDR methylation.

18. Data show that data demonstrate that tumor protein translationally-controlled 1 (TCTP) overexpression has a promotion effect on caudal type homeo box transcription factor 2 protein (CDX2) and villin1 protein (VIL1) expression.

19. Transfection of LS174T cells showed that the VTI1A promoter is highly active compared to the TCF7L2 promoter, and that CDX2 activates transcription of VTI1A.

20. The damaging p.Cys132* and p.Arg237His de novo CDX2 variants were identified in two patients. These variants altered the expression of CYP26A1, a direct CDX2 target encoding the major retinoic acid (RA)-degrading enzyme. Other RA genes, including the RA-receptor alpha, were also mutated.

Pig (Porcine) Caudal Type Homeobox 2 (CDX2) Interaktionspartner

1. Data show that SLC7A7 is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 promoter.

2. these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.

3. showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse

Mouse (Murine) Caudal Type Homeobox 2 (CDX2) Interaktionspartner

1. In mice, mosaic knockout of Cdx2 in the adult intestinal epithelium induces the formation of imperfect gastric-type metaplastic lesions.

2. Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells.

3. AMPK enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter.

4. CDX2(Null)/BRAF(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF(V600E)-mutant epithelium expressed gastric markers.

5. including Wnt and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx/Hox and T Brachyury transcriptional networks controls differential axial growth during vertebrate trunk elongation

6. A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha in human biopsy samples.

7. Cdx members interact with the SWI-SNF complex and make direct contact with Brg1, a catalytic member of SWI-SNF. Both Cdx2 and Brg1 co-occupy a number of Cdx target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.

8. The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox gene.

9. Cdx1-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac and a block in hematopoietic differentiation from yolk sac-derived cells in culture.

10. this study shows that Aloe vera gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer

11. Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 and Cdx2 in colon cancer cells.

12. CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs may be activated or repressed.

13. cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.

14. findings illuminated a role for NOD1 signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells

15. Overexpression of CDX2 inhibits the growth of the gastric cancer cells in vivo and in vitro.

16. Intestinal stem cells transform into gastric stem cells on loss of transcription factor Cdx2.

17. GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2

18. pSMAD/CDX2 interaction is essential for the switch toward an intestinal phenotype in Barrett's esophagus.

19. Cdx2 is important for the correct specification of trophoectoderm from the morula stage.

20. These findings underscore previously unrecognized roles for Cdx members in intestinal tumorigenesis

Cow (Bovine) Caudal Type Homeobox 2 (CDX2) Interaktionspartner

1. Removal of Wnt3a from the culture medium resulted in downregulation (p < 0.05) of NANOG, OCT4, CDX2, and Action: Trophoblast stem cell(TSC) marker genes, and upregulation of TSC differentiation markers, including MASH2, GCM1, and PAG

2. results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.