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anti-Mouse (Murine) PPP1R13B Antikörper:
anti-Human PPP1R13B Antikörper:
anti-Rat (Rattus) PPP1R13B Antikörper:
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Human Polyclonal PPP1R13B Primary Antibody für IHC, ELISA - ABIN1584021 : Matsumoto, Weckbecker, Cory: Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells. in Cancer communications 1990 (PubMed) Show all 2 Pubmed References
Human Polyclonal PPP1R13B Primary Antibody für IF (p), IHC (p) - ABIN674379 : Xie, Yang, Chi, Yang, Wang, Xu: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study. in Chinese journal of cancer 2017 (PubMed)
After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (zeige FUT1 Antikörper)) cycling and induces p53 (zeige TP53 Antikörper)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (zeige FUT1 Antikörper) self-renewal and accumulation of DNA damage in p53 (zeige TP53 Antikörper) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (zeige TP53BP2 Antikörper) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (zeige TP53 Antikörper)-independent manner.
results provide new insights into EGR-1 (zeige EGR1 Antikörper)/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1 (zeige EGR1 Antikörper)/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (zeige TP53 Antikörper) and ASPP1 and downregulation of iASPP (zeige PPP1R13L Antikörper).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein (zeige LAT Antikörper) C (zeige PROC Antikörper)-Nap1 (zeige CEP250 Antikörper). Co-depletion of ASPP1 and ASPP2 (zeige TP53BP2 Antikörper) inhibited re-association of C-Nap1 (zeige CEP250 Antikörper) with centrosome at the end of mitosis.
ASPP1 and ASPP2 (zeige TP53BP2 Antikörper) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (zeige TP53 Antikörper).
When the Px(T)PxR (zeige NR1I2 Antikörper) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (zeige TP53BP2 Antikörper) and iASPP (zeige PPP1R13L Antikörper).
the mRNA expression of ASPP1 and ASPP2 (zeige TP53BP2 Antikörper) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (zeige TP53 Antikörper)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (zeige YAP1 Antikörper) results in the decreased expression of LATS2 (zeige LATS2 Antikörper), which lowers the ability of p53 (zeige TP53 Antikörper) to induce p21 (zeige CDKN1A Antikörper), cell-cycle arrest and senescence.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
protein phosphatase type 2C alpha 1 , protein phosphatase 1, regulatory (inhibitor) subunit 13B , apoptosis-stimulating protein of p53, 1 , apoptosis-stimulating of p53 protein 1-like , apoptosis-stimulating of p53 protein 1 , protein phosphatase 1 regulatory subunit 13B , transformation related protein 53 binding protein 2 , tumor protein p53 binding protein, 2 , tumor protein p53-binding protein, 2 , apoptosis-stimulating protein of p53