anti-GTPase NRas (NRAS) Antikörper

Bezeichnung:: anti-GTPase NRas Antikörper (NRAS)

Auf www.antikoerper-online.de finden Sie aktuell 130 GTPase NRas (NRAS) Antikörper von 0 unterschiedlichen Herstellern. Insgesamt sind aktuell 162 GTPase NRas Produkte verfügbar.

Synonyme:: ALPS4, AV095280, fj99a10, H-RAS, HRAS, N-RAS, NRAS, NRAS1, NS6, wu:fj99a10, zgc:100761, zras-b1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
Anti-Ratte NRAS	NRAS	24605	Q04970
Anti-Maus NRAS	NRAS	18176
Anti-Human NRAS	NRAS	4893	P01111
Weitere Synonyme anzeigen

Verknüpfte Pathways mit anti-GTPase NRas Antikörper

VEGF Signaling

Weitere Produktkategorien zu GTPase NRas Antikörper

Am meisten referenzierte anti-GTPase NRas Antikörper

Human Polyclonal GTPase NRas Primary Antibody für IHC (p), IHC - ABIN409077 : Thomas, Edmiston, Alexander, Millikan, Groben, Hao, Tolbert, Berwick, Busam, Begg, Mattingly, Ollila, Tse, Hummer, Lee-Taylor, Conway: Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 (PubMed)
Human Monoclonal GTPase NRas Primary Antibody für WB - ABIN1882272 : Hall, Brown: Human N-ras: cDNA cloning and gene structure. in Nucleic acids research 1985 (PubMed)

Weitere Antikörper gegen GTPase NRas Interaktionspartner

Mouse (Murine) GTPase NRas (NRAS) Interaktionspartner

A sequential and coordinated activation of ERK (zeige EPHB2 Antikörper), JNK (zeige MAPK8 Antikörper) and STAT3 (zeige STAT3 Antikörper) with RACK1 (zeige GNB2L1 Antikörper) is shown to accelerate aggressive melanoma development in vivo.
MEK1 (zeige MAP2K1 Antikörper) does not act as a general tumor suppressor in leukemogenesis. Rather, its effects strongly depend on the genetic context (RAS versus MYC (zeige MYC Antikörper)-driven leukemia) and on the cell type involved.
our data indicate that endogenous NrasQ61R/+ induces an increase of Nras-GTP (zeige AK3 Antikörper) and cytokine-evoked signaling, which is intermediate between NrasG12D/+ and NrasG12D/G12D
Interleukin-8 (zeige IL8 Antikörper)-related chemokines were identified as the tumor cell-secreted culprits for NRAS-dependent pulmonary metastatic propensity, signaling to lung endothelial and myeloid cells to facilitate pulmonary invasion.
complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
loss of one allele of Hras (zeige HRAS Antikörper) increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras (zeige HRAS Antikörper) allele. However, loss of one or both alleles of Nras failed to alter tumor burden, either in the absence or presence of Hras (zeige HRAS Antikörper), after exposure to urethane.
Genetic inactivation of Ezh2 (zeige EZH2 Antikörper) or Eed (zeige EED Antikörper) cooperates with NRASQ61K in leukemogenesis.
Data indicate that S-phase kinase-associated protein 2 (SKP2) cooperates with N-Ras and AKT proto-oncogenes to promote hepatocarcinogenesis in vivo.
Activated NRAS and aberrant Wnt (zeige WNT2 Antikörper) signaling conspire to drive congenital melanocytic nevus syndrome.
a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

Human GTPase NRas (NRAS) Interaktionspartner

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.
N-Ras preferentially populated raft domains when bound to mant-GDP. It lost its preference for rafts when associated with a GTP (zeige AK3 Antikörper) mimic, mant-GppNHp. The isolated lipidated C-terminal peptide of N-Ras was outside of the liquid-ordered rafts, most likely in the bulk-disordered lipid. Substitution of the N-Ras N-terminal G domain with a homologous G domain of H-Ras (zeige HRAS Antikörper) disrupted the nucleotide-dependent lipid domain switch.
We report herein for the first time that 30% of cutaneous NRAS mutant melanomas have a high M%NRAS. Chromosome instability, (chromosome 1 polysomy, intratumor copy number variation of chromosome1/NRAS) rather than the acquired copy neutral LOH seems to be responsible for most of the cases with high M%NRAS.
NRAS status (exons 2-4) was analyzed by Pyrosequencing in a case series of 50 squamous cell anal carcinoma patients.
NRAS-mutant tumors tended to behave more aggressively particularly in early stages of the disease in studied high-risk melanoma population.
Data show that mutations in NRAS are associated with poor survival.
Authors analyzed 421 samples from CLM patients for their all-RAS mutation status to compare the overall survival rate (OS), recurrence-free survival rate (RFS), and the pattern of recurrence between the patients with and without RAS mutations.
Findings indicate neurofibromin 1 (NF1 (zeige NF1 Antikörper)) as the most frequently occurring driver mutation in mucosal melanoma, and RAS alterations, consisting of NRAS and KRAS mutations, were the second most frequent mutation type.
The lack of KRAS, NRAS, BRAF (zeige BRAF Antikörper), and PIK3CA (zeige PIK3CA Antikörper) mutation in our study may suggest that a subset of eyelid sebaceous carcinomas is unlike that of eyelid sebaceous carcinomas of western countries.
in vitro assays confirmed that decreased miR-425 strongly induced inflammatory cytokines (interleukin [IL]-2 and interferon [IFN]-gamma) via N-Ras upregulation in the TCR signalling pathway in primary biliary cholangitis

Zebrafish GTPase NRas (NRAS) Interaktionspartner

Although oncogenic NRAS expression alone was found to be insufficient to promote tumor formation, loss of functional p53 (zeige TP53 Antikörper) was found to collaborate with NRAS expression in the genesis of melanoma.

GTPase NRas (NRAS) Antigen-Profil

Beschreibung des Gens

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Alternative names and synonyms associated with GTPase NRas (NRAS)

GTPase NRas (Tsp_01117) Antikörper
neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog (nras.L) Antikörper
NRAS proto-oncogene, GTPase (Nras) Antikörper
neuroblastoma ras oncogene (Nras) Antikörper
NRAS proto-oncogene, GTPase (NRAS) Antikörper
NRAS proto-oncogene, GTPase (nras) Antikörper
neuroblastoma RAS viral oncogene homolog (NRAS) Antikörper

ALPS4 Antikörper
AV095280 Antikörper
fj99a10 Antikörper
H-RAS Antikörper
HRAS Antikörper
N-RAS Antikörper
NRAS Antikörper
NRAS1 Antikörper
NS6 Antikörper
wu:fj99a10 Antikörper
zgc:100761 Antikörper
zras-b1 Antikörper

Bezeichner auf Proteinebene für anti-GTPase NRas (NRAS) Antikörper

GTPase NRas , transforming protein N-Ras , neuroblastoma RAS viral (v-ras) oncogene homolog , N-ras oncogene , p21 protein , N-ras protein part 4 , v-ras neuroblastoma RAS viral oncogene homolog , ras p21 , N-ras oncogene p21 , etID18709.8 , neuroblastoma RAS viral oncogene-like protein , neuroblastoma ras oncogene , v-Ha-ras Harvey rat sarcoma viral oncogene homolog

GENE ID	SPEZIES
10905151	Trichinella spiralis
399446	Xenopus laevis
24605	Rattus norvegicus
18176	Mus musculus
100135584	Cavia porcellus
4893	Homo sapiens
403872	Canis lupus familiaris
30380	Danio rerio
419885	Gallus gallus
100739349	Sus scrofa
506322	Bos taurus
100174317	Pongo abelii

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