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PAI1 Proteine

(Plasminogen Activator Inhibitor 1 (SERPINE1))
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

42 Treffer

SERPINE1 Spezies: Maus Wirt: Human Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7935770
3.892,90 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
SERPINE1 Spezies: Human Wirt: Human Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7935769
3.584,90 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • ELISA
    • SDS-PAGE (SDS)
    • Immunogen (Imm)
    • Antibody Production (AbP)
    • Positive Control (PC)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Functional Studies (Func)
    • Protein Interaction (PI)
  • Reaktivität
    • Human
    • Mouse
    • Rat
    • Cow
    • Monkey
    • Pig
    • E. coli
    • Rabbit
    • Rhesus Monkey
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Nur ohne Konservierungsmittel
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Human Cells
    • Yeast
    • Mammalian Cells
    • Wheat germ
  • Bindungsspezifität
    • AA 24-402
    • AA 1-402
    • AA 22-402
    • AA 23-402
    • Transcript Variant 1
    • AA 141-389
    • AA 24-401
    • AA 349-390
    • AA 86-185
    • partial
  • Konjugat
    • His tag
    • Unkonjugiert
    • GST tag
    • His-SUMO Tag
    • Fc Tag
    • His-IF2DI Tag
    • Myc-DYKDDDDK Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
    • Biologically Inactive
  • Hersteller
    • antibodies-online
    • Signalway
    • Abbexa
    • CUSABIO
    • OriGene
    • ITSI-Biosciences

Aktuelle Publikationen für unsere PAI1 Proteine

Reichel, Hessenauer, Pflieger, Rehberg, Kanse, Zahler, Krombach, Berghaus, Strieth: "Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116883, (2015) (PubMed).

Florova, Azghani, Karandashova, Schaefer, Koenig, Stewart-Evans, Declerck, Idell, Komissarov: "Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits." in: American journal of respiratory cell and molecular biology, Vol. 52, Issue 4, pp. 429-37, (2015) (PubMed).

Dinarvand, Hassanian, Weiler, Rezaie: "Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation." in: Blood, Vol. 125, Issue 8, pp. 1339-48, (2015) (PubMed).

Simone, Higgins, Archambeault, Higgins, Ginnan, Singer, Higgins: "A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage." in: Cellular signalling, Vol. 27, Issue 5, pp. 923-33, (2015) (PubMed).

Yang, Kuan: "Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 4, pp. 367-73, (2015) (PubMed).

Komissarov, Florova, Azghani, Buchanan, Bradley, Schaefer, Koenig, Idell: "The time course of resolution of adhesions during fibrinolyitic therapy in tetracycline-induced pleural injury in rabbits." in: American journal of physiology. Lung cellular and molecular physiology, pp. ajplung.00136.2015, (2015) (PubMed).

Damare, Brandal, Fortenberry: "Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers." in: Nucleic acid therapeutics, Vol. 24, Issue 4, pp. 239-49, (2014) (PubMed).

Wan, Gao, Zhou, Zhang, Hao, Lian, Li, Chen, Liu: "SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence." in: Aging cell, Vol. 13, Issue 5, pp. 890-9, (2014) (PubMed).

Florova, Karandashova, Declerck, Idell, Komissarov: "Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex." in: Biochemistry, Vol. 52, Issue 27, pp. 4697-709, (2013) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Aliase für PAI1 Proteine

serpin family E member 1 (SERPINE1) Proteine
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog (serpine1.L) Proteine
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) Proteine
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) Proteine
serpin family E member 1 (Serpine1) Proteine
PAI Proteine
PAI-1 Proteine
PAI1 Proteine
Pai1 Proteine
PAI1A Proteine
Pai1aa Proteine
Planh Proteine
PLANH1 Proteine
Planh1 Proteine
RATPAI1A Proteine
SERPINE1 Proteine
si:ch211-138a11.1 Proteine
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