PAI1 Proteine
(Plasminogen Activator Inhibitor 1 (SERPINE1))
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
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SERPINE1
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
SERPINE1
Spezies: Maus
Wirt: Hefe
Recombinant
> 90 %
SDS
1 image
SERPINE1
Spezies: Ratte
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
SERPINE1
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
SERPINE1
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
SERPINE1
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
Aktuelle Publikationen für unsere PAI1 Proteine
: "Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116883, (2015) (PubMed).: "Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits." in: American journal of respiratory cell and molecular biology, Vol. 52, Issue 4, pp. 429-37, (2015) (PubMed).
: "Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation." in: Blood, Vol. 125, Issue 8, pp. 1339-48, (2015) (PubMed).
: "A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage." in: Cellular signalling, Vol. 27, Issue 5, pp. 923-33, (2015) (PubMed).
: "Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 4, pp. 367-73, (2015) (PubMed).
: "The time course of resolution of adhesions during fibrinolyitic therapy in tetracycline-induced pleural injury in rabbits." in: American journal of physiology. Lung cellular and molecular physiology, pp. ajplung.00136.2015, (2015) (PubMed).
: "Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers." in: Nucleic acid therapeutics, Vol. 24, Issue 4, pp. 239-49, (2014) (PubMed).
: "SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence." in: Aging cell, Vol. 13, Issue 5, pp. 890-9, (2014) (PubMed).
: "Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex." in: Biochemistry, Vol. 52, Issue 27, pp. 4697-709, (2013) (PubMed).
: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).
Aliase für PAI1 Proteine
serpin family E member 1 (SERPINE1) Proteineserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog (serpine1.L) Proteine
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) Proteine
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) Proteine
serpin family E member 1 (Serpine1) Proteine
PAI Proteine
PAI-1 Proteine
PAI1 Proteine
Pai1 Proteine
PAI1A Proteine
Pai1aa Proteine
Planh Proteine
PLANH1 Proteine
Planh1 Proteine
RATPAI1A Proteine
SERPINE1 Proteine
si:ch211-138a11.1 Proteine
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