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Using domain exchanges and individual amino acid switches between THRA1 (zeige THRA Proteine) and THRB2, three amino acids were identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1 (zeige THRA Proteine).
Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (zeige IHH Proteine) gene.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (zeige SMAD1 Proteine) signaling.
Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.
Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development.
Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC (zeige MYC Proteine) expression.
T3 induces FGF21 (zeige FGF21 Proteine) in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE (zeige TREH Proteine) within intron 2 of FGF21 (zeige FGF21 Proteine). But T3 induced most gene expression in liver independently of FGF21 (zeige FGF21 Proteine).
TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 (zeige ECM1 Proteine) regulatory subunit of PI3K and the Src kinase (zeige CSK Proteine) Lyn (zeige LYN Proteine) in the absence of thyroid hormone (zeige PTH Proteine).
TRbeta-related deafness originates outside of hair cells and that TRalpha (zeige GNAT1 Proteine) and TRbeta play opposing, non-redundant roles in hair cells.
Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII (zeige NR2F2 Proteine).
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (zeige PTH Proteine) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
Data suggest that the embryonic to larval transitory phase is characterized by its dependency on the timely synthesis of thyroid hormone (zeige PTH Proteine) and the concomitant autoinductive increase in thyroid hormone receptor beta mRNA levels.
In certain contexts, Rb loss enables TRbeta1-dependent suppression of SKP2 as a safeguard against RB1 (zeige RB1 Proteine)-deficient tumorigenesis. TRbeta2 counteracts TRbeta1, thus disrupting this safeguard and promoting development of RB1 (zeige RB1 Proteine)-deficient malignancies.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (zeige TRIB1 Proteine) and TRb2 (zeige TRIB2 Proteine)-mediated PTTG1 (zeige PTTG1 Proteine) inhibition, counteracting Rb-deficiency-related genomic instability.
the actions of R429Q-TRbeta1 in Resistance to Thyroid Hormone (RTH)-Syndrome most likely reflect the reduced hormone affinity observed for this mutant rather than an alteration in target gene repertoire.
The present studies uncovered a novel mechanism by which thyroid hormone receptor beta could function as a tumor suppressor through modulation of TNF alpha-IkappaB alpha-NFkappaB pathway.
Novel THRB single nucleotide substitution-C to G in codon 340 in resistance to thyroid hormone (zeige PTH Proteine) syndrome.
THRA (zeige THRA Proteine) predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation.
TRbeta (zeige TXNRD2 Proteine) suppressed Runx2 (zeige RUNX2 Proteine) transcriptional activities, thus confirming TRbeta (zeige TXNRD2 Proteine) regulation of Runx2 (zeige RUNX2 Proteine) at functional thyroid hormone (zeige PTH Proteine)-response elements. Significantly, these findings indicate that a ratio of the tumor-suppressor TRbeta (zeige TXNRD2 Proteine) and tumor-promoting Runx2 (zeige RUNX2 Proteine) may reflect tumor aggression and serve as biomarkers in biopsy tissues. The discovery of this TRbeta (zeige TXNRD2 Proteine)-Runx2 (zeige RUNX2 Proteine) signaling supports the emerging role of TRbeta (zeige TXNRD2 Proteine) as a tumor supp...
results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 (zeige PDCD4 Proteine) and THRB
it was observed that ER stimulated gene expression by interacting with MEIS1 (zeige MEIS1 Proteine) and FOXP3 (zeige FOXP3 Proteine), and ER inhibited gene expression by interacting with THRB and GRHL1 (zeige GRHL1 Proteine).
presents 1 pedigree of thyroid hormone (zeige PTH Proteine) resistance syndrome with heterozygous A317T mutation in THRbeta gene in the proband and his mother, which is the first reported mutation in Chinese and provides a comprehensive review of available literature
Increased expression of mammary TRbeta1 and DIO2 (zeige DIO2 Proteine), and decreased RXRalpha (zeige RXRA Proteine), provide a mechanism to increase thyroid hormone (zeige PTH Proteine) activity within the mammary gland during lactation.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
thyroid hormone receptor beta
, nuclear receptor subfamily 1 group A member 2
, thyroid hormone receptor beta isoform
, thyroid hormone receptor beta 3
, thyroid hormone receptor beta2delta
, thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
, TR beta
, thyroid hormone receptor beta 1
, thyroid hormone receptor beta 2
, thyroid hormone receptor beta-1
, oncogene ERBA2
, thyroid hormone nuclear receptor beta variant 1
, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
, thyroid hormone receptor beta2
, beta-thyroid hormone receptor