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RORgammat(+) iNKT and gammadelta-hi T cells show IL-23 mediated Th17-like immune responses and were clearly enriched within inflamed joints of spondyloarthritis patients where they act as major IL-17 secretors.
Herein, molecular dynamics simulations were conducted on HC9-ROR-gamma and XY018-ROR-gamma complexes to understand their conformational features at molecular level and the influence of XY018 binding on the dynamics of ROR-gamma with the aid of post-dynamic analytical tools.
RORgammat mRNA expression levels were significantly different among groups of Hepatitis B virus infection patients with different disease severities.
siRNA-mediated knockdown of T-bet and RORgammaT contributes to decreased inflammation in preeclampsia.
human melanoma development and aggressiveness is associated with decreased expression of RORalpha and RORgamma, suggesting that RORs could be important in melanoma progression and host responses against the tumor
There was no significant difference in FOXP3, RORgammat, IL-10 protein expression and supernatant PBMCs IL-10 in chronic heart failure patients as compared to control.
TNF-alpha inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300, CBP and PCAF in Th17 cells, from rheumatoid arthritis patients.
Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 pathway
CYP11A1- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1.
The interaction between c-Maf and RORgammat, and Blimp-1.
RORgammat and RORalpha have overlapping roles in human Th17 cell differentiation through regulation of a defined common set of Th17 genes
this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
this study shows that all human innate lymphoid cells can be generated through an RORgammat+ developmental pathway from a common progenitor in secondary lymphoid tissues
ROR-gamma is overexpressed and amplified in metastatic castration resistant prostate tumors, and ROR-gamma drives androgen receptor (AR) expression in the tumors. ROR-gamma recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, also known as SRC-1 and SRC-3) to an AR-ROR response element (RORE) to stimulate AR gene transcription.
Data suggest that apo RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.
There is selective migration or survival of RORgammat-positive cells in Secondary Progressive Multiple Sclerosis patient meninges.
Retinoid-related orphan receptor gammat may be associated with NK22 cells in reproduction. Particularly, higher expression of retinoid-related orphan receptor gammat may be associated with elevated NK22 cells in unexplained recurrent pregnancy loss.
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor C allele variation on intramuscular fat in beef cattle is reported.
The RORC:g.3290T>G single nucleotide polymorphism had the strongest association with marbling.
Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity.
RORalpha/gamma controls circadian expression of Insig2, which keeps feeding-induced SREBP1c activation under check
Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.
the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH 5826 (SCH) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A(+), RORgammat(+), Foxp3(+), and IL-10(+) in CD4(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
pharmacological inhibition of RORgamma skews TCRalpha gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis.targeting RORgammaT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.
Heterozygous deletion of RORgammat gene resulted in aggravated cardiac remodeling, accompanied by reduced capillary density, after MI, suggesting that RORgammat-expressing cells contribute to tissue repair in infarcted myocardium
we identified a two-amino-acid substitution in RORgammat (RORgammat(M)) that 'preferentially' disrupted TH17 differentiation but not thymocyte development. Mice expressing RORgammat(M) were resistant to EAE associated with defective TH17 differentiation but maintained normal thymocyte development and normal lymph-node genesis, except for Peyer's patches.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
RORgamma/IL-17A axis influences VEGF production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORgamma and IL-17A may have potential for the improved treatment of neovascular retinopathies.
secretion of IL-17 by biTregs was abrogated completely in FoxP3(Cre) x RORC(fl/fl) mice. Furthermore, Tregs showed a more activated phenotype after cell-specific inactivation of RORgammat signalling. Finally, and remarkably, biTregs were found to potently suppress anti-inflammatory Th2 immunity in a RORgammat-dependent manner.
this paper shows that RORgammat antagonist, A213 suppresses Sjogren's syndrome-like sialadenitis
this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression
The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut-specific immune responses, rendering Foxp3-RORgt T cells as an important effector Treg subset in the intestinal system.
up-regulated expression in abortion mouse model
Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 and GFP (RORgammat)
Epidermal Notch1 recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Overexpression of RORgammat Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium.
Results reveal differential requirements for ROR-gammat in the maintenance of TH17 cell and group 3 innate lymphoid cell responses in intestinal inflammation.
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor