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siRNA-mediated knockdown of T-bet and RORgammaT contributes to decreased inflammation in preeclampsia.
There was no significant difference in FOXP3 (zeige FOXP3 Proteine), RORgammat, IL-10 (zeige IL10 Proteine) protein expression and supernatant PBMCs IL-10 (zeige IL10 Proteine) in chronic heart failure patients as compared to control.
TNF-alpha (zeige TNF Proteine) inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300 (zeige EP300 Proteine), CBP (zeige CREBBP Proteine) and PCAF (zeige KAT2B Proteine) in Th17 cells, from rheumatoid arthritis patients.
Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 (zeige IL17A Proteine) pathway
CYP11A1 (zeige CYP11A1 Proteine)- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1 (zeige TGFB1 Proteine).
The interaction between c-Maf (zeige MAF Proteine) and RORgammat, and Blimp-1 (zeige PRDM1 Proteine).
this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
IKKalpha (zeige CHUK Proteine)-dependent phosphorylation of S376 stimulated whereas IKKalpha (zeige CHUK Proteine)-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor (zeige NR1D2 Proteine) C allele variation on intramuscular fat in beef cattle is reported.
RORalpha/gamma controls circadian expression of Insig2 (zeige INSIG2 Proteine), which keeps feeding-induced SREBP1c (zeige SREBF1 Proteine) activation under check
Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3 (zeige FOXP3 Proteine)(+) precursors in autoimmunity has been described.
the potential effects of the A2A adenosine receptor (A2AR (zeige ADORA2A Proteine)) antagonist SCH (zeige NF2 Proteine) 5826 (SCH (zeige NF2 Proteine)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (zeige IL17A Proteine)(+), RORgammat(+), Foxp3 (zeige FOXP3 Proteine)(+), and IL-10 (zeige IL10 Proteine)(+) in CD4 (zeige CD4 Proteine)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
pharmacological inhibition of RORgamma skews TCRalpha gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis.targeting RORgammaT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1 (zeige NCOA1 Proteine)
RORgamma/IL-17A (zeige IL17A Proteine) axis influences VEGF (zeige VEGFA Proteine) production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORgamma and IL-17A (zeige IL17A Proteine) may have potential for the improved treatment of neovascular retinopathies.
secretion of IL-17 (zeige IL17A Proteine) by biTregs was abrogated completely in FoxP3 (zeige FOXP3 Proteine)(Cre) x RORC(fl/fl (zeige FLT3LG Proteine)) mice. Furthermore, Tregs showed a more activated phenotype after cell-specific inactivation of RORgammat signalling. Finally, and remarkably, biTregs were found to potently suppress anti-inflammatory Th2 immunity in a RORgammat-dependent manner.
this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor