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Findings indicate that Gc globulin (GC) rs16847024, retinoid X receptor gamma (RXRG) rs17429130 and retinoid X receptor alpha (RXRA) rs4917356 were candidate susceptibility markers for gestational diabetes mellitus (GDM) in Chinese females.
genetic association studies in a population in Brazil: Data suggest that SNPs in RXRG (rs2134095) and GC (rs7041) are associated with low-density lipoprotein cholesterol levels and hypercholesterolemia in the population studied; there was no apparent association with an SNP in VDR (rs2228570). (RXRG = retinoid X receptor gamma; GC = vitamin D-binding protein; VDR = vitamin D receptor)
Germline mutations in the RXRG gene are linked to Familial isolated pituitary adenoma in a Brazilian Family.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR.
Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms.
loss of RXR-gamma levels appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer
Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients.
The RXR-gamma rs3818569 single nucleotide polymorphisms is associated with diabetic retinopathy development in the Taiwanese population.
results indicate that RXR-gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination.
RXRgamma and PPARgamma ligands acted synergistically to inhibit proliferation and invasiveness in colon cancer cells.
methylation-associated downregulation of the RXRG gene may play a differential role in the carcinogenesis of non-small cell lung cancer (NSCLC) according to smoking status.
RXRalpha and RXRgamma immunodetected in all normal, nodular, and basal cell hyperplasia, as well as carcinomatous prostates. In atrophic glands, the expression of both receptors was found in 22.5% of samples.
Single nucleotide polymorphism not a factor in resistance to thyroid hormone.
Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression may have roles in apoptosis of thyroid carcinoma
The retinoid X receptor, gamma expression is mainly restricted to the muscle and brain.
These results show that the stimulation of ASCT2 expression in response to glutamine in part involves binding of FXR/RXR to the ASCT2 promoter.
RXRgamma contributes to the genetic background of familial combined hyperlipidemia.
These data indicate that the RAR/RXR heterodimer is a critical regulator of human hematopoietic stem cell (HSC) differentiation, and pharmacological modulation of RXR signaling prevents the loss of human HSCs that otherwise occurs in short-term culture.
Retinoic X receptor-gamma (RXRG) gene was studied as a candidate gene for the twinning trait of bovine.
Data show that halcinonide and clobetasol act as Smoothened (Smo) agonists to up-regulate myelin gene expression and retinoid X receptor gamma (RxRgamma) activation.
RXR-gamma plays an important role in tight control of glucose metabolism in the fasting-feeding cycle.The regulation of RXR-gamma expression in the liver by feeding or glucose.
Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis.
The data of this study argued that control of NAc dopamine d2 receptor expression is critical for Retinoid x receptor gamma-mediated modulation of affective behaviors.
The ablation of all RXR (alpha, beta and gamma isotypes) in Sertoli cells does not recapitulate the phenotype generated upon ablation of all three retinoic acid receptors.
RXR/LXR up-regulates SREBP1c gene expression and FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
nuclear receptor subfamily 2 group B member 3
, retinoic acid receptor RXR-gamma
, retinoid X receptor gamma
, nuclear receptor subfamily 2 group B member 3-B
, retinoic acid receptor RXR-gamma-B
, retinoid X receptor gamma-B
, retinoid X receptor, gamma
, RXR gamma-1
, retinoic X receptor gamma-1