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Cow (Bovine) Monoclonal PPARA Primary Antibody für ChIP, FACS - ABIN152696
Sumanasekera, Tien, Turpey, Vanden Heuvel, Perdew: Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. in The Journal of biological chemistry 2003
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Cow (Bovine) Polyclonal PPARA Primary Antibody für ChIP, ELISA - ABIN153509
Selwyn, Cheng, Klaassen, Cui: Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. in Drug metabolism and disposition: the biological fate of chemicals 2016
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Human Monoclonal PPARA Primary Antibody für WB - ABIN1944858
Mukherjee, Jow, Noonan, McDonnell: Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. in The Journal of steroid biochemistry and molecular biology 1995
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Human Polyclonal PPARA Primary Antibody für ICC, IHC (fro) - ABIN3044397
Zhou, Zhang, Xu, Wang: Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. in Journal of pharmacological sciences 2015
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Mouse (Murine) Polyclonal PPARA Primary Antibody für IF, IP - ABIN285918
Suardíaz, Estivill-Torrús, Goicoechea, Bilbao, Rodríguez de Fonseca: Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. in Pain 2007
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Mouse (Murine) Polyclonal PPARA Primary Antibody für IHC, ELISA - ABIN105798
Plutzky: Medicine. PPARs as therapeutic targets: reverse cardiology? in Science (New York, N.Y.) 2003
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Cow (Bovine) Polyclonal PPARA Primary Antibody für ELISA, ICC - ABIN4346988
Baker, Ball, Rakha, Nolan, Caldas, Ellis, Green: Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer. in Breast cancer research and treatment 2012
Human Polyclonal PPARA Primary Antibody für IF (p), IHC (p) - ABIN753163
Mölzer, Wallner, Kern, Tosevska, Schwarz, Zadnikar, Doberer, Marculescu, Wagner: Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health. in Scientific reports 2016
Mouse (Murine) Monoclonal PPARA Primary Antibody für GS, IP - ABIN284693
Longuet, Sinclair, Maida, Baggio, Maziarz, Charron, Drucker: The glucagon receptor is required for the adaptive metabolic response to fasting. in Cell metabolism 2008
Polymorphism of PPARA is associated with late onset of type 2 diabetes mellitus.
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha signaling, inhibiting the TLR4 (zeige TLR4 Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (zeige TLR4 Antikörper)/ERK1/2/AP-1 (zeige FOSB Antikörper)/STAT3 (zeige STAT3 Antikörper)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
data suggested that miR (zeige MLXIP Antikörper)-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN (zeige GAL Antikörper)/LPS (zeige IRF6 Antikörper)-stimulated hepatocytes via regulating NBR2 and AMPK (zeige PRKAA1 Antikörper)/PPARalpha signaling.
The minor allele of rs1800206 and rs1805192 from PPAR A and PPAR G (zeige ARF6 Antikörper) and its interaction were associated with increased Breast Cancer risk.
High concentrations of DINCH urinary metabolites activate human PPAR-alpha.
PPARalpha is overexpressed in primary glioblastoma
these results suggest that the E2F1 (zeige E2F1 Antikörper)/miR19a/PPARalpha feedback loop is critical for glioma progression
Data conclude that the ER-stress mediated reduction in apoA-I (zeige APOA1 Antikörper) transcription could be partly mediated via the inhibition of PPARalpha mRNA expression and activity. In addition, BET inhibition increased apoA-I (zeige APOA1 Antikörper) transcription, even if PPARalpha production and activity were decreased. Both BET inhibition and PPARalpha activation ameliorate the apoA-I (zeige APOA1 Antikörper) lowering effect of ER-stress and are therefore interesting targets to elev...
Results demonstrated that PPARa directly inhibited Glut1 (zeige SLC2A1 Antikörper) mRNA expression resulting in influx of glucose in cancer cells.
PPARalpha and LXRalpha (zeige NR1H3 Antikörper) may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (zeige SLC22A5 Antikörper) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (zeige PPARG Antikörper)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (zeige PTGS2 Antikörper) levels in bovine endometrial stromal cells.
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (zeige DGAT1 Antikörper) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (zeige ADIPOR1 Antikörper) (SSC10p13) and CREB (zeige CREB1 Antikörper) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM (zeige MUC19 Antikörper)) may contribute to the susceptibility of BSM (zeige MUC19 Antikörper) to lipotoxicity in the metabolic syndrome.
Clofibrate treatment revealed an essential role of PPARalpha in regulating hepatic bile acid synthesis, transport and signaling.
IL-6 and aging are involved in regulation of PPARalpha and PGC-1alpha expression and may influence the mitochondrial function.
The authors identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits
p21 (zeige D4S234E Antikörper) plays a relevant role in fasting adaptation through the positive regulation of PPARalpha.
PPARalpha is required for the ChREBP (zeige MLXIPL Antikörper)-induced glucose response of FGF21 (zeige FGF21 Antikörper). Loss of PPARalpha impairs Fgf21 (zeige FGF21 Antikörper) promoter accessibility at the carbohydrate-responsive element .
Data, including data from studies in knockout mice, suggest that hepatic induction of cytochrome P450s (Cyp3a, Cyp2b, and Cyp2c) by hypolipidemic agent gemfibrozil is suppressed by Ppara activation.
We demonstrated that PPARalpha activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF (zeige GTF2A1L Antikörper)), particularly through regulating CHOP (zeige DDIT3 Antikörper). Our findings may provide a rationale for targeting PPARalpha as a potential therapeutic strategy to ameliorate ALF (zeige GTF2A1L Antikörper).
These findings indicate that PPARalpha promotes osteogenic differentiation via the Sirt1 (zeige SIRT1 Antikörper)-dependent signaling pathway.
CD36 (zeige CD36 Antikörper) is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR)-related transcriptional responses in the muscle with exercise training.
In mice, the oral administration of linalool for 3 weeks reduced plasma TG concentrations in Western-diet-fed C57BL/6J mice (31%, P < 0.05) and human apo (zeige C9orf3 Antikörper) E2 mice (50%, P < 0.05) and regulated hepatic PPARalpha target genes.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor alpha
, ppar alpha
, xPPAR alpha
, peroxisome proliferator-activated receptor-alpha