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anti-Human NR5A2 + LRH1 Antikörper:
anti-Mouse (Murine) NR5A2 + LRH1 Antikörper:
anti-Rat (Rattus) NR5A2 + LRH1 Antikörper:
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Human Polyclonal NR5A2 + LRH1 Primary Antibody für WB - ABIN3043579
Zhao, Wen, Zheng, Sun, Sun, Ni: Action mechanism of Zuo Gui Yin Decoction's promotion on estradiol production in rats during the peri-menopausal period. in Journal of ethnopharmacology 2011
Human Polyclonal NR5A2 + LRH1 Primary Antibody für ELISA, WB - ABIN4331473
Yumoto, Nguyen, Sablin, Baxter, Webb, Fletterick: Structural basis of coactivation of liver receptor homolog-1 by β-catenin. in Proceedings of the National Academy of Sciences of the United States of America 2012
Human Polyclonal NR5A2 + LRH1 Primary Antibody für ICC, IF - ABIN4331468
Benod, Vinogradova, Jouravel, Kim, Fletterick, Sablin: Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2011
Using the cells derived from the model, novel SF-1/Ad4BP- and LRH-1-regulated genes were identified by combined DNA microarray and promoter tiling array analyses. The interaction of SF-1/Ad4BP and LRH-1 with transcriptional regulators in the regulation of ovarian steroidogenesis was also revealed.
The results of our study indicate that LRH1 predicts NSCLC progression, metastasis, and a dismal prognosis, emphasizing its promising role as a novel target in NSCLC therapies.
study identified LRH1-driven pathway as a circuitry responsible for hepatocyte identity by using cistromic analysis, improving our understanding of liver pathophysiology and identifying novel therapeutic targets.
These findings not only demonstrate the significant role of the nuclear receptor LRH-1 in the promotion of intratumoral androgen biosynthesis in castration-resistant prostate cancer (CRPC) via its direct transcriptional control of steroidogenesis, but also suggest targeting LRH-1 could be a potential therapeutic strategy for CRPC management.
rs2816948 not significantly associated with recurrent abortions
LRH1 is highly expressed in chemotherapy-resistant breast cancer.LRH1 enhanced breast cancer cell chemoresistance by upregulating MDC1 and attenuating DNA damage.
Results found the mRNA and protein expression levels of LRH1 were significantly higher in HepG2 and HuH6 hepatoblastoma cell lines and results suggest that LRH1 may contribute to cell proliferation in hepatoblastoma. Hepatoblastoma cells with higher LRH1 expression levels more susceptible to LRH1 inhibition.
LRH-1 maintains intestinal epithelial health and protects against inflammatory damage.
Lrh-1 transcriptionally regulates Oat2.
Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor.
transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas; findings support the notion that, in the pancreas, the transcriptional networks involved in differentiation-specific functions also suppress inflammatory programs; under conditions of genetic or environmental constraint, these networks can be subverted to foster inflammation
our data indicated that miR-381 inhibited migration and invasion of non-small cell lung cancer (NSCLC)by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC.
NR5A2-mediated cancer cell survival is facilitated through augmentation of GATA6 and anti-apoptotic factor BCL-XL levels.
the expression level of LRH-1 can be used as a marker in the early diagnosis of unexplained recurrent spontaneous abortion.
Liver receptor homologue1 (LRH1) is a direct target of miR30d in colorectal carcinoma cells.
Results show that LRH-1 is a direct target gene of miR-374b and that decreased miR-374b expression may contribute to the promotion of LRH-1-mediated tumorigenesis of colon cancer.
NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted
Our study suggests that miR-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1.
Liver receptor homolog-1 was identified as a direct target gene of miR-136
miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues.
role for NR5A2 and its SUMOylation on the transcriptional regulation of the calreticulin gene in a model of renal fibrosis
Nr5a2 s a key component of an expanded primordial germ cells gene regulatory network.
LRH-1 agonism favors an immune cells-islet dialogue which protects against diabetes mellitus.
potent suppressor of neural stem cell self-renewal and key player in neural fate decisions through direct regulatory effects on critical genes and pathways
The data identify the key role of biliary phospholipids in sustaining intestinal mucosa proliferation and tumor progression through the activation of nuclear receptor Lrh1.
It was concluded that Nr5a2 is essential for cumulus expansion in granulosa cells throughout follicular development.
results suggest that Sod2 is a target gene of LRH-1, and that LRH-1 agonists can mediate a reduction in ROS production and oxidative stress driven by an excess of fatty acids, as exhibited in nonalcoholic fatty liver disease
These findings suggest that compromised SUMOylation of LRH-1 promotes the development of nonalcoholic fatty liver disease under lipogenic conditions through regulation of OSBPL3.
these data show for the first time LRH-1 expression in T cells, its role in FASLG transcription and the potential of pharmacological inhibition of LRH-1 in the treatment of FasL-mediated immunopathologies
highlight the importance of LRH-1 in coordinating glutamine-induced metabolism and signaling to promote hepatocellular carcinogenesis.
Mice carrying a mutation on lysine 289 of LRH-1 (Lrh1 K289R mice) display reduced LRH-1 SUMOylation and increased expression of genes regulating cholesterol transport.
Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARgamma axis.
The authors conclude that LRH-1 initiates a novel pathway of endoplasmic reticulum stress resolution that is independent of the unfolded protein response, yet equivalently required.
study demonstrates for the first time that LRH-1 has a CRT-dependent NES which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.
these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in WD and potentially in other disorders associated with increased hepatic copper levels.
Heterozygous gene deletion of LRH-1 causes body weight gains without any apparent worsening of glucose and lipid metabolism.
NR5A2 has a role in controlling aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis
Report fully reversible infertility phenotype of LRH-1-knockdown mice.
GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers.
NR5A2 (LRH-1, SF2) mRNA is upregulated in granulosa cells of dominant and hCG-induced ovulatory ovarian follicles.
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
nuclear receptor subfamily 5, group A, member 2
, Ftz-F1-related orphan receptor A
, FTZ-F1-related nuclear orphan receptor
, Ftz-F1-related orphan receptor
, liver receptor-like protein 1
, CYP7A promoter-binding factor
, alpha-1-fetoprotein transcription factor
, b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
, fetoprotein-alpha 1 (AFP) transcription factor
, hepatocytic transcription factor
, liver nuclear receptor homolog-1 variant 2
, liver receptor homolog 1
, liver receptor homolog-1
, nuclear receptor NR5A2
, nuclear receptor subfamily 5 group A member 2
, Ftz-F1-related orphan receptor B
, fetoprotein transcription factor
, FTZ-F1 beta
, FTZ-F1 beta2 protein