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Human Polyclonal NR1I2 Primary Antibody für IHC, ELISA - ABIN1584988
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
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Human Polyclonal NR1I2 Primary Antibody für IF (p), IHC (p) - ABIN679598
Sehirli, Cetinel, Ozkan, Selman, Tetik, Yuksel, Dulger: St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2015
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Human Polyclonal NR1I2 Primary Antibody für IHC, WB - ABIN2774988
Hesselink, van Schaik, Nauta, van Gelder: A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. in Pharmacogenomics 2008
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Human Polyclonal NR1I2 Primary Antibody für ELISA, WB - ABIN449909
Thakur, Arthanari, Yang, Pan, Fan, Breger, Frueh, Gulshan, Li, Mylonakis, Struhl, Moye-Rowley, Cormack, Wagner, Näär: A nuclear receptor-like pathway regulating multidrug resistance in fungi. in Nature 2008
Dual ligands of CAR/PXR show distinct gene regulation patterns by regulating cross-talk between CAR and PXR.
High PXR expression is associated with multidrug resistance in breast cancer.
PXR, CYP3A4 (zeige CYP3A4 Antikörper), and VIL1 (zeige VIL1 Antikörper) expression was decreased only in the actively inflamed small intestinal tissue in children with Crohn's disease.
NR1I2 g.7635A>G had a significant interaction with time, but the dose-adjusted tacrolimus concentration did not significantly differ over 5 years post-transplantation, except for the GG genotype of NR1I2 g.7635A>G.
Together, our results suggest that protection of the endothelial barrier by APC (zeige APC Antikörper)/TR47-mediated signaling pathways might be a valuable therapeutic approach to prevent metastasis
Mulberroside A significantly suppressed PXR-mediated P-gp (zeige ABCB4 Antikörper) luciferase activity induced by rifampicin (Rif).
This data indicates that 14-3-3sigma contributes to P-gp (zeige ABCB4 Antikörper) overexpression through interaction with PXR with rifampin and paclitaxel treatment.
Data suggest both PXR and CAR are expressed in testis (zeige XKR3 Antikörper)/Sertoli cells; exposure of Sertoli cells (in vitro model of blood-testis barrier) to PXR or CAR ligands (including antiretroviral drugs) up-regulates expression of Pgp/ABCB1 (zeige ABCB4 Antikörper), BCRP (zeige ABCG2 Antikörper), and MRP4 (zeige ABCC4 Antikörper). (PXR = pregnane X receptor; CAR = constitutive androstane receptor (zeige NR1I3 Antikörper); Pgp/ABCB1 (zeige ABCB4 Antikörper) = P-glycoprotein ABCB1 (zeige ABCB1 Antikörper); BCRP (zeige ABCG2 Antikörper) = breast cancer resistance protein (zeige ABCG2 Antikörper); MRP4 (zeige ABCC4 Antikörper) =multidrug resistance protein 4)
Genetic variations in PXR affect induction of Bupropion hydroxylation by sodium ferulate.
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (zeige SRC Antikörper) coactivator.
The regulatory effect of IFN-gamma (zeige IFNG Antikörper) on CYP3A29 expression is mediated via PXR.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
In conclusion, PXR and FXR (zeige NR1H4 Antikörper) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (zeige NR1H4 Antikörper) transactivation at in vivo expression levels.
the PXR gene revealed multiple splice variants in the ligand-binding domain
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands.
FGF21 (zeige FGF21 Antikörper)-PXR signaling pathway may be involved in decreased hepatic CYP3A4 (zeige CYP3A4 Antikörper) metabolic activity in Nonalcoholic fatty liver disease.
Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con (zeige KITLG Antikörper) A.
carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage
PXR activation stimulates EGF (zeige EGF Antikörper)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (zeige FOXO3 Antikörper) from accelerating cell-cycle progression.
The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.
modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.
results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.
Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.
Selected zebrafish CYP1 (zeige PPIA Antikörper), CYP2 and CYP3 genes appear to be under the regulation of both pregnane X receptor and aryl hydrocarbon receptor (zeige AHR Antikörper) 2.
CYP3A65 and PXR may be involved in the metabolization and detoxification of microcystins in zebrafish, which may be regulated by dre (zeige SUFUH Antikörper)-miR (zeige MYLIP Antikörper)-27b.
similar pattern of mRNA expression of PXR, cytochrome P4503A and multiple drug resistance 1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
nuclear receptor subfamily 1 group I member 2
, orphan nuclear receptor PAR1
, orphan nuclear receptor PXR
, pregnane X nuclear receptor variant 2
, pregnane X receptor
, steroid and xenobiotic receptor
, Pregnane X receptor
, nuclear receptor subfamily 1, group 1, member 2
, pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
, nuclear receptor subfamily 1 group I member 2 S homeolog
, nuclear receptor subfamily 1, group I, member 2
, orphan nuclear receptor BXR-beta