anti-F2R (F2R) Antikörper

Bezeichnung:: anti-Coagulation Factor II (thrombin) Receptor Antikörper (F2R)

Auf www.antikoerper-online.de finden Sie aktuell 195 Coagulation Factor II (thrombin) Receptor (F2R) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und F2R Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 300 F2R Produkte verfügbar.

Synonyme:: AI482343, Cf2r, EMK1, f2r-a, HTR, Par-1, par1, Par1b, ThrR, TR, TRGPC

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	F2R	2149	P25116
	F2R	25439
	F2R	14062	P30558
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human F2R Antikörper:

anti-Rat (Rattus) F2R Antikörper:

anti-Mouse (Murine) F2R Antikörper:

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Verknüpfte Pathways mit anti-F2R Antikörper

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Am meisten referenzierte anti-F2R Antikörper

Human Polyclonal F2R Primary Antibody für IF (p), IHC (p) - ABIN728743 : Liu, Xie, Luo, Chen, Zhou, Xia, Chen, Zhou, Cao, Cao, Zhou: Identification of FLOT2 as a novel target for microRNA-34a in melanoma. in Journal of cancer research and clinical oncology 2014 (PubMed)
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Human Polyclonal F2R Primary Antibody für WB - ABIN611146 : Gradin, Larsson, Marklund, Gullberg: Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells. in The Journal of cell biology 1998 (PubMed)
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Human Polyclonal F2R Primary Antibody für WB - ABIN2801899 : Shapiro, Trejo, Zeng, Coughlin: Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. in The Journal of biological chemistry 1997 (PubMed)
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Human Monoclonal F2R Primary Antibody für ELISA, WB - ABIN969339 : Nakayama, Kawato, Watanabe, Ohtsuka, Yoshida, Yokomizo, Sakamoto, Kuru, Ohta, Hoshino, Yoshida, Ishida, Cho, Palme, Zhang, Lee, Watkins: MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model. in Bioorganic & medicinal chemistry letters 2003 (PubMed)
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Human Polyclonal F2R Primary Antibody für CyTOF, FACS - ABIN4899990 : Doni, Musso, Morone, Bastone, Zambelli, Sironi, Castagnoli, Cambieri, Stravalaci, Pasqualini, Laface, Valentino, Tartari, Ponzetta, Maina, Barbieri, Tremoli, Catapano, Norata, Bottazzi, Garlanda et al.: An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. ... in The Journal of experimental medicine 2015 (PubMed)
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Human Polyclonal F2R Primary Antibody für ELISA, ICC - ABIN6265563 : Zhong, Chen, Zhang, Xiao, Qin, Gu, Sun, Liu, Jing, Hu, Zhang, Zhou, Sun, Yang: Doxycycline directly targets PAR1 to suppress tumor progression. in Oncotarget 2017 (PubMed)
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Human Monoclonal F2R Primary Antibody für ELISA, ICC - ABIN4343604 : Gonda, Watanabe, Ohuchi, Higuchi: In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. in The Journal of biological chemistry 2010 (PubMed)
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Human Monoclonal F2R Primary Antibody für PLA, ELISA - ABIN515442 : Fazzini, DAntongiovanni, Giusti, Da Valle, Ciregia, Piano, Caputo, DUrsi, Gargini, Lucacchini, Mazzoni: Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma cell line, NCI-H28, with homozygous deletion of the ?-catenin gene. in PLoS ONE 2014 (PubMed)
Human Monoclonal F2R Primary Antibody für ELISA, WB - ABIN966804 : Heider, Schulze, Oswald, Henklein, Scheele, Kaufmann: PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. in Oncology research 2004 (PubMed)
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Human Monoclonal F2R Primary Antibody für FACS - ABIN4897018 : Hagag, Nosair, Ghaith, Elshenawy: Prognostic value of protease activated receptor-1 in children with acute lymphoblastic leukemia. in Mediterranean journal of hematology and infectious diseases 2014 (PubMed)

Weitere Antikörper gegen F2R Interaktionspartner

Human Coagulation Factor II (thrombin) Receptor (F2R) Interaktionspartner

The activation of PAR-1 (zeige MARK2 Antikörper) on the cell surface of SGC7901 and AGS (zeige JAG1 Antikörper) cells was significantly reduced after the knockdown of EPCR (zeige PROCR Antikörper). By contrast, blockade of PAR-1 (zeige MARK2 Antikörper) reduced the proliferation and migration of gastric cells in vitro
Our structural data showed subtle changes in the binding pose between Vorapaxar and F16357. Transmembrane helices 1, 2, 5, and 7 were most significantly affected; most notably a large kink at F279(5.47) in TM helix 5 of the Vorapaxar complex was completely absent in the F16357 complex. The results of this study facilitate the future development of other therapeutic PAR1 (zeige MARK2 Antikörper) antagonists.
Platelets were activated in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, and such activation was at least partially attributed to the thrombin (zeige F2 Antikörper)-protease-activated receptors (PARs (zeige EPRS Antikörper)) pathway.
Using protein C (zeige PROC Antikörper)-factor VII (zeige TH Antikörper) chimera demonstrate that APC (zeige APC Antikörper) light chain amino acid residues outside the EPCR (zeige PROCR Antikörper)-binding site enable cytoprotective PAR1 (zeige MARK2 Antikörper) signaling.
Study demonstrated that nerve activation by mucosal biopsy supernatants depends on proteases. This is a common feature of quiescent ulcerative colitis and irritable bowel syndrome (IBS) and may relate to some common gastrointestinal symptoms. However, only proteases in IBS supernatants signal through PAR1 (zeige MARK2 Antikörper).
Data show there was no significant correlation of autoantibodies to coagulation factor II thrombin receptor (F2R; protease-activated receptor 1, PAR1) (PAR1-AB) level with , progression-free (PFS) and overall (OS) survival.
we found that activation of the protease-activated receptor 1 (PAR1) induced secretion of TSLP (zeige TSLP Antikörper) by the corneal stromal cells... we proposed that TSLP (zeige TSLP Antikörper) might function as the link between increased protease activity and inflammatory responses or itch sensation in the
PAR-1 (zeige MARK2 Antikörper) in non-small-cell lung cancer is mainly expressed on cells that constitute the pulmonary tumor microenvironment, including vascular endothelial cells, macrophages and stromal fibroblasts.
thrombin (zeige F2 Antikörper) binding to PAR-1 (zeige MARK2 Antikörper) receptor activated Gi-protein/c (zeige PROC Antikörper)-Src (zeige SRC Antikörper)/Pyk2 (zeige PTK2B Antikörper)/EGFR (zeige EGFR Antikörper)/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/p42/p44 (zeige PSMC6 Antikörper) MAPK (zeige MAPK3 Antikörper) cascade, which in turn elicited AP-1 (zeige FOSB Antikörper) activation and ultimately evoked MMP-9 (zeige MMP9 Antikörper) expression and cell migration in SK-N-SH cells.
this study demonstrates that TGFbeta (zeige TGFB1 Antikörper) is a positive regulator of PAR-1 (zeige MARK2 Antikörper) expression in A549 lung adenocarcinoma cells, which in turn increases the sensitivity of these cells to thrombin (zeige F2 Antikörper) signalling

Mouse (Murine) Coagulation Factor II (thrombin) Receptor (F2R) Interaktionspartner

PAR-1 (zeige MARK2 Antikörper) plays an important role in the development of diabetic nephropathy (DN) and PAR-1 (zeige MARK2 Antikörper) might therefore be an attractive therapeutic target to pursue in DN.
Experimental TCDD-elicited steatohepatitis is associated with coagulation cascade activation and PAR-1 (zeige MARK2 Antikörper)-driven hepatic inflammation and fibrosis.
PAR1 in its inactive unligated state functions as a scaffold for TGFbetaRII to downregulate TGF-beta (zeige TGFB1 Antikörper) signaling, and thereby promote embryonic stem cell transition to functional endothelial cells.
this study shows that poly I:C treated PAR-1 (zeige MARK2 Antikörper)-/- mice given the thrombin (zeige F2 Antikörper) inhibitor dabigatran etexilate exhibited less IFNbeta and CXCL10 (zeige CXCL10 Antikörper) expression in the spleen and plasma
Brain water content in the ipsilateral hemisphere and the tumor mass were significantly lower in PAR-1 (zeige MARK2 Antikörper) KO than WT mice at day 12 after implantation of glioma cells.
The results of this study suggested that polarized microglia occur dynamically after ICH (zeige ACE Antikörper) and that PAR-1 (zeige MARK2 Antikörper) plays a role in the microglia activation and polarization.
In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Antikörper)-activatable receptor PAR-1 (protease-activated receptor-1), in Runx1 (zeige RUNX1 Antikörper)/Cbfb (zeige CBFB Antikörper)-deleted MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells. Similar to the effect of Runx1 (zeige RUNX1 Antikörper)/Cbfb (zeige CBFB Antikörper) deletion, PAR-1 (zeige MARK2 Antikörper) overexpression induced CDKN1A/p21 (zeige CDKN1A Antikörper) expression and attenuated proliferation in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells
our findings define a detrimental role of thrombin (zeige F2 Antikörper)-activated PAR-1 (zeige MARK2 Antikörper) in wound healing in mice with spinal cord injuries.
thrombin (zeige F2 Antikörper)/PAR-1 (zeige MARK2 Antikörper) interaction regulated MCP-1 (zeige CPT1B Antikörper), TF, MCSF (zeige CSF1 Antikörper) and IL-6 (zeige IL6 Antikörper) production.
Thrombin (zeige F2 Antikörper) upregulates LCN2 (zeige LCN2 Antikörper) through protease-activated receptor-1 activation and causes brain damage.

Pig (Porcine) Coagulation Factor II (thrombin) Receptor (F2R) Interaktionspartner

Thrombin (zeige F2 Antikörper) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA (zeige RHOA Antikörper), and myocardin (zeige MYOCD Antikörper).
Thrombin (zeige F2 Antikörper) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Antikörper)+).

Cow (Bovine) Coagulation Factor II (thrombin) Receptor (F2R) Interaktionspartner

MMP-1 (zeige MMP1 Antikörper) promotes VEGFR2 (zeige KDR Antikörper) expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB (zeige NFKB1 Antikörper)
PAR1 and PAR2 (zeige F2RL1 Antikörper) regulate endothelial NO synthase (zeige NOS Antikörper) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2R Antigen-Profil

Beschreibung des Gens

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.

Alternative names and synonyms associated with F2R

coagulation factor II thrombin receptor (F2R) Antikörper
coagulation factor II (thrombin) receptor (F2r) Antikörper
microtubule affinity regulating kinase 2 (MARK2) Antikörper
coagulation factor 2 (thrombin) receptor L homeolog (f2r.L) Antikörper
coagulation factor II thrombin receptor (F2r) Antikörper

AI482343 Antikörper
Cf2r Antikörper
EMK1 Antikörper
f2r-a Antikörper
HTR Antikörper
Par-1 Antikörper
par1 Antikörper
Par1b Antikörper
ThrR Antikörper
TR Antikörper
TRGPC Antikörper

Bezeichner auf Proteinebene für F2R

protease-activated receptor 1 , proteinase-activated receptor 1 , PAR-1 , Thrombin receptor , coagulation factor II receptor , thrombin receptor , protease-activated receptor-1 , coagulation factor II (thrombin) receptor

GENE ID	SPEZIES
2149	Homo sapiens
25439	Rattus norvegicus
483769	Canis lupus familiaris
14062	Mus musculus
100521609	Sus scrofa
526585	Bos taurus
378526	Xenopus laevis
100719323	Cavia porcellus

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