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anti-Mouse (Murine) FOXL2 Antikörper:
anti-Rat (Rattus) FOXL2 Antikörper:
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Human Polyclonal FOXL2 Primary Antibody für ChIP, ELISA - ABIN249959
Jamieson, Butzow, Andersson, Alexiadis, Unkila-Kallio, Heikinheimo, Fuller, Anttonen: The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010
Show all 26 Pubmed References
Human Polyclonal FOXL2 Primary Antibody für IHC, ELISA - ABIN185040
Crisponi, Deiana, Loi, Chiappe, Uda, Amati, Bisceglia, Zelante, Nagaraja, Porcu, Ristaldi, Marzella, Rocchi, Nicolino, Lienhardt-Roussie, Nivelon, Verloes, Schlessinger, Gasparini, Bonneau, Cao, Pilia: The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. in Nature genetics 2001
Show all 3 Pubmed References
Cow (Bovine) Polyclonal FOXL2 Primary Antibody für WB - ABIN610539
Ayllón, Cayla, García, Roncal, Fernández, Albar, Martínez, Rebollo: Bcl-2 targets protein phosphatase 1 alpha to Bad. in Journal of immunology (Baltimore, Md. : 1950) 2001
Cow (Bovine) Polyclonal FOXL2 Primary Antibody für WB - ABIN2777885
Tang, Wang, Lin, Sun, Wang, Yu: Mutation analysis of the FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome. in Mutagenesis 2006
Human Polyclonal FOXL2 Primary Antibody für IF (p), IHC (p) - ABIN1715065
Cai, Sun, Li, Tsinkgou, Yu, Ying, Chen, Shi: Molecular mechanisms of enhancing porcine granulosa cell proliferation and function by treatment in vitro with anti-inhibin alpha subunit antibody. in Reproductive biology and endocrinology : RB&E 2015
Data show that cytochrome P450 (zeige CYP Antikörper) enzymes Cyp17 (zeige CYP17A1 Antikörper)-I, Cyp11c1 (zeige CYP11B2 Antikörper), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (zeige FOXO4 Antikörper) Foxl2a were detected both in the testis and ovary.
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus
Xenopus W-linked DM-W induces foxl2 expression during ovary formation.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (zeige WNT4 Antikörper)- and FOXL2-driven ovarian-determining pathways.
direct overexpression of Foxl2 decreased the expression of Sertoli cell-specific genes in primary Sertoli cells. Taken together, these results demonstrate that repression of beta-catenin (CTNNB1 (zeige CTNNB1 Antikörper)) signaling is required for lineage maintenance of Sertoli cells.
evidence that FOXL2 modulates Col1a2 (zeige COL1A2 Antikörper) transcription through interaction with a response element 65 Kb upstream of the transcription start site
Data indicate that a balance between supporting cell (zeige PTPRJ Antikörper) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 (zeige WNT4 Antikörper) protein/beta-catenin (zeige CTNNB1 Antikörper) and p27Kip1 (zeige CDKN1B Antikörper) protein (p27 (zeige CDKN1B Antikörper))/Forkhead box L2 (FOXL2) activities.
Data indicate that the hypothalamic-pituitary-gonadal axis controls expression of Foxl2 in pituitary gonadotropes primarily through positive feedback from ovarian hormones.
FOXL2 mobilizes estrogen signaling to establish a coherent feed-forward loop repressing Sox9.
Foxl2 has a crucial role in postnatal uterine maturation and could help to understand sub-fertility predisposition in women.
Results support FOXL2 as a master transcription factor in a spectrum of developmental processes, including growth, cartilage and bone formation. Its action overlaps that of SOX9 (zeige SOX9 Antikörper), though they are antagonistic in female vs male gonadal sex determination but conjoint in cartilage and skeletal development.
Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 (zeige INSL3 Antikörper) in GDX (zeige UBL4A Antikörper)-induced adrenocortical tumors of the mouse.
our results demonstrate the necessity of FOXL2 for proper FSH (zeige BRD2 Antikörper) production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHbeta promoter.
Despite exhibiting an immunophenotype characteristic of a sex cord-stromal tumor, mutations in FOXL2 and DICER1 (zeige DICER1 Antikörper), the 2 most common mutations hitherto reported in ovarian sex cord-stromal tumors, are not a feature of Uterine tumor resembling ovarian sex cord tumor (UTROSCT).
This report describes the preservation of heterozygous c.402C>G FOXL2 mutation in recurrent aGCTs. This finding adds further credence to the concept that the c.402C>G FOXL2 mutation is oncogenic and integral to this disease.
The novel mutations of the FOXL2 are associated with blepharophimosis, ptosis and epicanthus inversus syndrome.
this study identified a novel regulatory circuit for ovarian AMH (zeige AMH Antikörper) production; specifically, through the coordinated interplay between FOXL2 and SF-1 (zeige NR5A1 Antikörper) that could control ovarian follicle development.
we report the identification of two novel and two recurrent heterozygous NOBOX (zeige NOBOX Antikörper) variants in 7 out of 107 patients, with a prevalence of 6.5% (upper 95% confidence limit of 11.17%). Several variants conserve the ability to interact with FOXL2 in intracellular aggregates
This is the first study reporting lacrimal gland(LG) volumes in BPES, describing a significant number of patients with LG agenesis. Molecular analysis of the FOXL2 gene revealed the presence of 8 distinct mutations.
In the case of aGCT, a well characterized mutation in the FOXL2 transcription factor (FOXL2 C134W) is found in almost all cases, which arguably defines the disease, although the molecular events that determine the stage, behavior and prognosis of aGCT remain to be determined.
We highlight the cooperation of WNT4 (zeige WNT4 Antikörper), RSPO1 (zeige RSPO1 Antikörper) and FOXL2 within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
The de novo mutation rate in FOXL2 is exceptionally high compared with other dominant disorders manifesting with an ocular phenotype.
SUMOylation of FOXL2 and PML (zeige PML Antikörper) Bodies
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.
forkhead box L2
, forkhead box protein L2
, transcription factor FOXL2
, forkhead transcription factor L2
, foxl2 protein
, fork-head box L2 transcription factor
, pituitary forkhead factor
, putative transcription factor foxl2
, forkhead transcription factor FOXL2
, Forkhead box protein L2