FOXL2 Antikörper

Produktnummer ABIN719156

Produktdetails anti-FOXL2 Antikörper

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Rind (Kuh), Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FOXL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Referenzen für anti-FOXL2 Antikörper (ABIN719156)

Liu, Meng, Wang, Yang, Zhang, Tang: "FOXL2 suppresses proliferation, invasion and promotes apoptosis of cervical cancer cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 4, pp. 1534-43, (2014) (PubMed).

Details zu FOXL2

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Andere Bezeichnung: FOXL2 (FOXL2 Produkte)

Synonyme: BPES antikoerper, BPES1 antikoerper, PFRK antikoerper, PINTO antikoerper, POF3 antikoerper, AU045128 antikoerper, Pfrk antikoerper, FOXL2 antikoerper, zgc:136549 antikoerper, foxl2 antikoerper, FoxL2 antikoerper, foxL2 antikoerper, forkhead box L2 antikoerper, forkhead box L2a antikoerper, forkhead box L2 S homeolog antikoerper, forkhead transcription factor L2 antikoerper, foxl2 protein antikoerper, fork-head box L2 transcription factor antikoerper, FOXL2 antikoerper, Foxl2 antikoerper, foxl2a antikoerper, foxl2 antikoerper, foxl2.S antikoerper, LOC751846 antikoerper, foxL2 antikoerper

Hintergrund:

Synonyms: blepharophimosis, Blepharophimosis epicanthus inversus and ptosis 1, Blepharophimosis epicanthus inversus and ptosis, BPES 1, BPES, BPES1, epicanthus inversus and ptosis 1, forkhead box L2, Forkhead box protein L2, forkhead transcription factor FOXL2, FOX L2, FOXL 2, FOXL2, FOXL2_HUMAN, PFRK, PINTO, POF 3, POF3.

Background: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Molekulargewicht: 45-50kDa

Gen-ID: 668

Pathways: Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity