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anti-Human Presenilin 1 Antikörper:
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Human Monoclonal Presenilin 1 Primary Antibody für ICC, IF - ABIN261601
Stahl, Diehlmann, Südhof: Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. in The Journal of biological chemistry 1999
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Human Polyclonal Presenilin 1 Primary Antibody für IHC, ELISA - ABIN1003039
Weihofen, Martoglio: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. in Trends in cell biology 2003
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Human Polyclonal Presenilin 1 Primary Antibody für IHC (p), ELISA - ABIN545739
Miklossy, Taddei, Suva, Verdile, Fonte, Fisher, Gnjec, Ghika, Suard, Mehta, McLean, Masters, Brooks, Martins: Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. in Neurobiology of aging 2003
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Human Polyclonal Presenilin 1 Primary Antibody für IF (p), IHC (p) - ABIN723755
Chu, Peng, Long, Wang, Luo, Sharma, He: Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice. in Acta biochimica et biophysica Sinica 2015
Human Monoclonal Presenilin 1 Primary Antibody für ELISA, ICC - ABIN268518
Scarpi, Cirelli, Matrone, Castronovo, Rosini, Occhiato, Romano, Bartali, Clemente, Bottegoni, Cavalli, De Chiara, Bonini, Calissano, Palamara, Garaci, Torcia, Guarna, Cozzolino: Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. in Cell death & disease 2012
Human Polyclonal Presenilin 1 Primary Antibody für IHC (p), WB - ABIN541305
Selkoe: The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. in Trends in cell biology 1999
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Human Polyclonal Presenilin 1 Primary Antibody für ELISA, ICC - ABIN4347240
Dursun, Gezen-Ak: Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin. in PLoS ONE 2017
Presenilin-1 targeted morpholino induces cognitive deficits, increased brain Abeta1-42 and decreased synaptic marker PSD-95
Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation
Both human PS2V and zebrafish PS1IV can stimulate gamma-secretase activity despite extreme structural divergence.
We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish
We now demonstrate that zebrafish embryos maintain relatively stable levels of normal Presenilin1 transcript and protein despite accumulating large amounts of aberrantly spliced presenilin1 transcript.
These results suggest that Psen2 plays a more prominent role in Notch signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 can be ameliorated by Psen1 loss.
PS1- and PS2-dependent substrate processing in murine cells lacking presenilins (PSs) or stably re-expressing human PS1 or PS2 in an endogenous PS-null (PSdKO) background, were studied.
Using primary fibroblasts and neurons reprogrammed from induced pluripotent stem cells derived from familial Alzheimer's disease (FAD) patients, studied role of BRCA1 protein underlying molecular neurodegeneration. Whole-transcriptome approach showed disturbances in cell cycle and DNA damage response in FAD fibroblasts; increased BRCA1 Ser1524 phosphorylated and abnormal PSEN1 ubiquitination and subcellular distribution.
p. F105L mutation of the PSEN1 gene has been found in the Chinese population, which may be involved in the pathogenesis of this familial Alzheimer's disease
Mutations in the PSEN1 gene causes familial Alzheimer's disease as a result of oxidative stress.
gamma-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic gamma-secretase subunit, presenilin-1 (PS1).
Young healthy adults carrying APOE epsilon4 and APP/presenilin-1/2 displayed different hippocampus functional connectivity patterns
The variable clinical findings associated with the S170F mutation of Presenilin-1 highlight the relevance of atypical phenotypes in the context of research and under a clinical perspective
results provide insights into the relationship between PS1 conformational changes and gamma-secretase activities
Report confirmed that PSEN1 Thr116Ile mutation was causative of an autosomal dominant early onset Alzheimer's disease. In silico predictions were performed to estimate the possible role of mutation, and confirmed that it could disturb the HL-I loop, resulting in significant possible disturbances in secretase functions.
Data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.
A subset of early-onset Alzheimer's disease is inherited as an autosomal-dominant trait and is associated with mutations in the genes encoding presenilin 1.
We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 DeltaE9 mutation, as well as healthy and gene-corrected isogenic controls.
The data of this study suggest a deficiency of PE and LPC levels in the temporal cortex from Alzheimer's Disease-PSEN1(E280A) and Sporadic Alzheimer's Disease brains with respect to healthy brains.
3 distinct conformations of gamma-secretase (open, semiopen, and closed) differ by tilting of helices 2 and 3 of PS1, directly controlling active site availability. The semiopen conformation shows the best fit of Abeta peptides, i.e., longer residence before release and by inference more trimming. The closed, hydrophobic conformation is largely inactive and the open conformation is active but provides less optimal inte...
Dominant negative effect of the loss-of-function gamma-secretase mutants on the wild-type enzyme through heterooligomerization has been demonstrated.
phosphorylation of PS1 at Ser367 does not affect gamma-secretase activity, but has a dramatic effect on Abeta levels in vivo
This study demonstrated that the Precuneus cortex brain wave in PSEN1 E280A Family at Risk of Developing Alzheimer's disease.
The results show that in cognitively normal young adults carrying presenilin-1mutations had different spontaneous brain activity patterns without cerebral structural differences.
PSEN1 gene polymorphisms in Caucasian Alzheimer's disease
A case control study confirms PSEN1 rs17125721 as a risk factor for familial AD in Brazil.
Study uncovers a role of PS in presynaptic mechanisms, through APP cleavage and regulation of Syt7, that highlights aberrant synaptic vesicle processing as a possible new pathway in Alzheimer's disease.
continuous ER Ca(2) efflux is directed to mitochondria and increases basal respiration and organellar ATP levels, is established by GSK3beta-mediated phosphorylation of presenilin-1, and is prevented by either knockdown of presenilin-1 or an inhibition/knockdown of GSK3beta.
that BACE1 functions as the enzyme initiating the first cleavage step and serves a scaffold for amyloid- beta precursor protein and Presenilin 1 endocytosis.
This study examines the effect of the familial Alzheimer disease presenilin mutant that lacks the ninth exon (PS1 E9) and does not undergo endoproteolysis on store-operated calcium (SOC) entry.
The altered expressions of hippocampal microRNAs were associated to the imbalance between neurotoxic and neuroprotective functions and seemed to affect neurodegeneration in PSEN1/PSEN2 double knockout mice more severely than in wild-type mice.
found a stronger requirement for Presenilin during mouse lens development
Under conditions of reduced glucose, the PS1/gamma-secretase system decreases neuronal losses by suppressing miR-212 and increasing its target survival factor, PEA15. These observations have implications for mechanisms of neuronal death under conditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders.
PS1 phosphorylated at Ser367 has an antiamyloidogenic function, promoting autophagosome-lysosome fusion and increasing betaCTF degradation
Fibroblast growth factor (FGF1 and FGF2), but not vascular endothelial growth factor (VEGF) rescued Psen1-/- cells from serum starvation induced apoptosis.In the absence of serum, FGF2 immunoreactivity was distributed diffusely in cytoplasmic and nuclear vesicles of wt and Psen1-/- cells, as levels of FGF2 in nuclear and cytosolic fractions were not significantly different.
Upregulated p53-p21 Signaling is linked with presenilin 1 mutants
The cognitive function of APP/PS1 mice was impaired at 10months of age; moreover, the hypermetabolic state identified in various brain regions at 5months of age was also significantly decreased.
Using knockout cell lines in combination with siRNA and immunoprecipitation approaches, our data clearly demonstrated that the Pen-2 and PS1 are sufficient to form a functionally active gamma-secretase that is capable of catalyzing the processing of Notch. This finding strongly suggests that Pen-2 is the most crucial component in gamma-secretase complex in addition to presenilin that functions as the catalytic subunit.
that reduction in the synaptotagmin 1 level and presenilin 1-synaptotagmin 1 interactions in AD brain may present molecular underpinning of the pathogenic presenilin 1 conformation
PS1 plays a crucial role in the cerebrovascular system and the vascular reactivity is decreased through altered Ca(2+) signals in PS1dE9 mutant mice.
Loss of PS1 is associated with cognitive impairment.
Cultured hippocampal neurons expressing mutant PS1 had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1.
Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction and ultrastructural cardiomyocyte abnormalities.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
, presenilin 1 (Alzheimer disease 3)
, presenilin-1 isoform I-463
, presenilin-1 isoform I-467
, presenilin 1
, presenilin alpha