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anti-Human Presenilin 1 Antikörper:
anti-Mouse (Murine) Presenilin 1 Antikörper:
anti-Rat (Rattus) Presenilin 1 Antikörper:
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Human Monoclonal Presenilin 1 Primary Antibody für ICC, IF - ABIN261601
Stahl, Diehlmann, Südhof: Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. in The Journal of biological chemistry 1999
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Human Polyclonal Presenilin 1 Primary Antibody für IHC, ELISA - ABIN1003039
Weihofen, Martoglio: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. in Trends in cell biology 2003
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Human Polyclonal Presenilin 1 Primary Antibody für IHC (p), WB - ABIN2476203
Sherrington, Rogaev, Liang, Rogaeva, Levesque, Ikeda, Chi, Lin, Li, Holman, Tsuda, Mar, Foncin, Bruni, Montesi, Sorbi, Rainero, Pinessi, Nee, Chumakov, Pollen, Brookes, Sanseau, Polinsky, Wasco et al.: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. ... in Nature 1995
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Human Polyclonal Presenilin 1 Primary Antibody für IF (p), IHC (p) - ABIN723755
Chu, Peng, Long, Wang, Luo, Sharma, He: Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice. in Acta biochimica et biophysica Sinica 2015
Human Monoclonal Presenilin 1 Primary Antibody für ELISA, ICC - ABIN268518
Scarpi, Cirelli, Matrone, Castronovo, Rosini, Occhiato, Romano, Bartali, Clemente, Bottegoni, Cavalli, De Chiara, Bonini, Calissano, Palamara, Garaci, Torcia, Guarna, Cozzolino: Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. in Cell death & disease 2012
Human Polyclonal Presenilin 1 Primary Antibody für ELISA, ICC - ABIN4347240
Dursun, Gezen-Ak: Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin. in PLoS ONE 2017
Human Polyclonal Presenilin 1 Primary Antibody für FACS, IF - ABIN390169
Nie, Li, Yan, Wang, Zhao, Guo, Yin: Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells. in Neurochemical research 2011
Presenilin-1 targeted morpholino induces cognitive deficits, increased brain Abeta1-42 and decreased synaptic marker PSD-95 (zeige DLG4 Antikörper)
Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation
We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish
These results suggest that Psen2 (zeige PSEN2 Antikörper) plays a more prominent role in Notch (zeige NOTCH1 Antikörper) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (zeige PSEN2 Antikörper) can be ameliorated by Psen1 loss.
Data indicate a novel role for PS1 in regulating TREM2 (zeige TREM2 Antikörper) intracellular trafficking and pathophysiological function.
A subset of early-onset Alzheimer's disease is inherited as an autosomal-dominant trait and is associated with mutations in the genes encoding presenilin 1.
We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 DeltaE9 mutation, as well as healthy and gene-corrected isogenic controls.
The data of this study suggest a deficiency of PE and LPC (zeige PCSK7 Antikörper) levels in the temporal cortex from Alzheimer's Disease-PSEN1(E280A) and Sporadic Alzheimer's Disease brains with respect to healthy brains.
3 distinct conformations of gamma-secretase (open, semiopen, and closed) differ by tilting of helices 2 and 3 of PS1, directly controlling active site availability. The semiopen conformation shows the best fit of Abeta (zeige APP Antikörper) peptides, i.e., longer residence before release and by inference more trimming. The closed, hydrophobic conformation is largely inactive and the open conformation is active but provides less optimal inte...
phosphorylation of PS1 at Ser367 does not affect gamma-secretase activity, but has a dramatic effect on Abeta (zeige APP Antikörper) levels in vivo
This study demonstrated that the Precuneus cortex brain wave in PSEN1 E280A Family at Risk of Developing Alzheimer's disease.
PSEN1 gene polymorphisms in Caucasian Alzheimer's disease
A case control study confirms PSEN1 rs17125721 as a risk factor for familial AD in Brazil.
PS1 increases the level of U1snRNA accompanied with the adverse change of Abeta (zeige APP Antikörper) level, AD-related tau cytoskeletal pathology, and SH-SY5Y cell apoptosis.
Under conditions of reduced glucose, the PS1/gamma-secretase system decreases neuronal losses by suppressing miR (zeige MLXIP Antikörper)-212 and increasing its target survival factor, PEA15 (zeige PEA15 Antikörper). These observations have implications for mechanisms of neuronal death under conditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders.
PS1 phosphorylated at Ser367 has an antiamyloidogenic function, promoting autophagosome-lysosome fusion and increasing betaCTF degradation
Fibroblast growth factor (FGF1 (zeige FGF1 Antikörper) and FGF2 (zeige FGF2 Antikörper)), but not vascular endothelial growth factor (VEGF (zeige VEGF Antikörper)) rescued Psen1-/- cells from serum starvation induced apoptosis.In the absence of serum, FGF2 (zeige FGF2 Antikörper) immunoreactivity was distributed diffusely in cytoplasmic and nuclear vesicles of wt and Psen1-/- cells, as levels of FGF2 (zeige FGF2 Antikörper) in nuclear and cytosolic fractions were not significantly different.
Upregulated p53 (zeige TP53 Antikörper)-p21 (zeige D4S234E Antikörper) Signaling is linked with presenilin 1 mutants
The cognitive function of APP (zeige APP Antikörper)/PS1 mice was impaired at 10months of age; moreover, the hypermetabolic state identified in various brain regions at 5months of age was also significantly decreased.
Using knockout cell lines in combination with siRNA and immunoprecipitation approaches, our data clearly demonstrated that the Pen-2 (zeige PSENEN Antikörper) and PS1 are sufficient to form a functionally active gamma-secretase that is capable of catalyzing the processing of Notch (zeige NOTCH1 Antikörper). This finding strongly suggests that Pen-2 (zeige PSENEN Antikörper) is the most crucial component in gamma-secretase complex in addition to presenilin that functions as the catalytic subunit.
that reduction in the synaptotagmin 1 (zeige SYT1 Antikörper) level and presenilin 1-synaptotagmin 1 (zeige SYT1 Antikörper) interactions in AD brain may present molecular underpinning of the pathogenic presenilin 1 conformation
PS1 plays a crucial role in the cerebrovascular system and the vascular reactivity is decreased through altered Ca(2 (zeige CA2 Antikörper)+) signals in PS1dE9 mutant mice.
Loss of PS1 is associated with cognitive impairment.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Antikörper) and PSEN1 genes via a STAT3 (zeige STAT3 Antikörper)-dependent pathway
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (zeige FLT1 Antikörper)
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
, presenilin 1 (Alzheimer disease 3)
, presenilin-1 isoform I-463
, presenilin-1 isoform I-467
, presenilin 1
, presenilin alpha