NLRP3 Produkte
(NLR Family, Pyrin Domain Containing 3 (NLRP3))
Kategorien
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008].
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Ausgewählte NLRP3 Kategorien
NLRP3 Antikörper
High quality antibodies with extensive validation data.
NLRP3 ELISA Kits
Reliable ELISA kits for a wide range of species.
NLRP3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NLRP3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC, IF, IP
Validierungen
- (60)
- (5)
Kat. Nr.
ABIN1169100
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Dog, Human, Mouse, Rat
Applikation
WB, ELISA, IHC (p), FACS, ICC, IHC (fro), IF (p), IF (cc)
Validierungen
- (11)
- (15)
Kat. Nr.
ABIN1386361
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7443710
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene NLRP3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6971279
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958210
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958211
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene NLRP3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7554745
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7564709
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (5)
- (1)
Kat. Nr.
ABIN1312675
Menge
2 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NLRP3 Produkten
: "Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation." in: Microbiology spectrum, Vol. 9, Issue 2, pp. e0073021, (2022) (PubMed).: "XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis-Induced Renal Inflammation and Oxidative Injury via the miR-223/NLRP3 Pathway." in: Oxidative medicine and cellular longevity, Vol. 2021, pp. 1676152, (2022) (PubMed).
: "MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3." in: Journal of cellular and molecular medicine, Vol. 24, Issue 24, pp. 14405-14414, (2021) (PubMed).
: "Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway." in: Nutrients, Vol. 12, Issue 5, (2021) (PubMed).
: "P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages." in: Cell death & disease, Vol. 11, Issue 5, pp. 394, (2021) (PubMed).
: "Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease." in: Frontiers in aging neuroscience, Vol. 13, pp. 629891, (2021) (PubMed).
: "Roseburia intestinalis‑derived flagellin ameliorates colitis by targeting miR‑223‑3p‑mediated activation of NLRP3 inflammasome and pyroptosis." in: Molecular medicine reports, Vol. 22, Issue 4, pp. 2695-2704, (2021) (PubMed).
: "NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis." in: Nature communications, Vol. 10, Issue 1, pp. 4375, (2020) (PubMed).
: "LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression." in: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).
: "25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner." in: Journal of neuroinflammation, Vol. 17, Issue 1, pp. 192, (2020) (PubMed).
Synonyme und alternative Namen zu NLRP3
NLR family pyrin domain containing-like (NLRPL), NLR family pyrin domain containing 3 (NLRP3), NLR family, pyrin domain containing 3 L homeolog (nlrp3.L), NLR family, pyrin domain containing 3 (Nlrp3), agtavprl, AGTAVPRL, AII, AII/AVP, avp, AVP, C1orf7, CIAS1, cias1, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, Nalp3, nalp3, NALP3, pypaf1, PYPAF1, Pypaf1Bezeichner auf Proteinebene für NLRP3
- NACHT, LRR and PYD domains-containing protein 3
- cold autoinflammatory syndrome 1
- cryopyrin
- NLR family, pyrin domain containing 3
- NACHT, LRR and PYD domains-containing protein 3-like
- NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
- NACHT, LRR and PYD containing protein 3
- PYRIN-containing APAF1-like protein 1
- caterpiller protein 1.1
- cold autoinflammatory syndrome 1 protein
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
- NACHT/LRR/pyrin domain-containing protein 3
- cold autoinflammatory syndrome 1 homolog
- cold autoinflammatory syndrome 1 protein homolog
- mast cell maturation inducible protein 1
- mast cell maturation-associated-inducible protein 1
- NLR family pyrin domain containing 3
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