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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305134
Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820
Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
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Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826
Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010
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Human Tumor Necrosis Factor Protein expressed in Wheat germ - ABIN1323120
Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014
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Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135
Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991
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Human Tumor Necrosis Factor Protein expressed in Pichia - ABIN988275
Fritz, Radziwill: CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. in Molecular cancer research : MCR 2010
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN935843
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (zeige INS Proteine)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.
The expression of miR (zeige MYLIP Proteine)-125b-1 regulated by NF-kappaB (zeige NFKB1 Proteine) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (zeige NFKB1 Proteine) in TNFalpha-stimulated HeLa and HepG2 cells
In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.
Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.
Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) signaling
The predicted 3D structures of IL-1beta (zeige IL1B Proteine), TNF-alpha, and IL-8 (zeige IL8 Proteine) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.
The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.
TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (zeige ADAM17 Proteine)-like activity that is regulated by ERK (zeige MAPK1 Proteine), JNK (zeige MAPK8 Proteine) and p38MAPK (zeige MAPK14 Proteine) signaling pathways.
Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.
Subjects carrying the GG genotype for the SNP rs1800629 at the TNFA gene show a greater activation of the proinflammatory status than A-allele carriers, which is related to ROS (zeige ROS1 Proteine) formation. These ROS (zeige ROS1 Proteine) could induce DNA damage especially in the telomeric sequence, by decreasing the telomere length and inducing cellular aging.
Study assessed the influence of TNF-alpha and IL-10 (zeige IL10 Proteine) single nucleotide polymorphisms on the progression of HCV-induced chronic hepatitis to cirrhosis in HIV-coinfected patients; -238 TNF-alpha (rs361525) and IL-10 (zeige IL10 Proteine) (rs1800872) assessed; in this cohort of Caucasian patients, TNF-alpha -238 polymorphism was involved in the risk of liver cirrhosis.
Our results suggest that TNF-alpha, IFN-gamma (zeige IFNG Proteine) and TGF-beta (zeige TGFB1 Proteine) function cooperatively to regulate the expressions of IL-6 (zeige IL6 Proteine) and MMP-9 (zeige MMP9 Proteine), and may play important roles in pathological behaviour of AMs (zeige MAT1A Proteine), such as bone resorption.
this study shows that TNFalpha significantly augments IFNgamma production from IL-2 (zeige IL2 Proteine)-/IL-12 (zeige IL12A Proteine)-treated NK cells in vitro, an effect mimicked by a TNFR2 (zeige TNFRSF1B Proteine) agonistic antibodies
the GA genotype of the TNF-alpha -308G>A polymorphism is a significant genetic risk factor for the pathogenesis of keratoconus (KC); this SNP was observed to be associated with deregulated expression of downstream molecules, t further reinforcing the role of the inflammatory pathway components in the development of KC
associations between the genetic variants and the LPS (zeige IRF6 Proteine)-induced IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), IL-10 (zeige IL10 Proteine), IL-1ra (zeige IL1RN Proteine) and TNF-alpha cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS (zeige IRF6 Proteine)-stimulated cytokine production; however, the potential for type II errors should be considered
Carriers of -308 GG promoter variant of TNF-alpha gene have a better metabolic response than -308 GA obese with a high protein hypocaloric diet
the carriage of the TNFA-308 A/A and GA genotype may act as a marker of enhanced susceptibility to contact polysensitization
CUX-1 (zeige CUX1 Proteine) overexpression enhanced TNF- production on sCD26 (zeige CDC26 Proteine)/LPS (zeige IRF6 Proteine) stimulation, while CUX-1 (zeige CUX1 Proteine) depletion had no effect. Neither CUX-1 (zeige CUX1 Proteine) overexpression nor CUX-1 (zeige CUX1 Proteine) depletion had an effect on IL-6 (zeige IL6 Proteine) stimulation. These results are discussed in the context of a model that describes the mechanisms by which stimulation of monocytic cells by sCD26 (zeige CDC26 Proteine) and LPS (zeige IRF6 Proteine) leads to elevation of TNF- and IL-6 (zeige IL6 Proteine) expression.
first proteomic study to identify inflammation factors such as TNF-alpha involved in thoracic ossification of the ligamentum flavum (TOLF), which may contribute to a better understanding of the cause of TOLF
Increased basal transmission and plasticity of glutamate (zeige GRIN1 Proteine) synapses that was related to increased levels of tumor necrosis factor alpha (TNFalpha).
Results showed that lncRNA SeT and miR (zeige MLXIP Proteine)-155 mediate Tnfalpha gene dosage control by regulating the homologous pairing of the two gene alleles and ultimately regulating its biallelic pattern.
Internalized CpG oligodeoxynucleotide (ODN)-conjugated PPMs (PPM-CpG) greatly enhance the induction of selected cytokines (TNF-alpha and IL-6 (zeige IL6 Proteine)) in RAW 264.7 cells compared to that by the soluble CpG ODN and ionic complexes.
Wnt10b (zeige WNT10B Proteine) expression was assessed by flow cytometry under estrogen- and TNFalpha-deficient conditions
Tumor necrosis factor (TNF), a cell-extrinsic potent negative regulator of hematopoietic stem cells (HSCs), was overexpressed in bone marrow niche cells from FLT3 (zeige FLT3 Proteine) internal tandem duplications (FLT3 (zeige FLT3 Proteine) ITDs) mice.
conclude that TNF-alpha produced by B2 cells is a key mechanism by which B2 cells promote atherogenesis through augmenting macrophage TNF-alpha production to induce cell death and inflammation that promote plaque vulnerability
robust caspase (zeige CASP3 Proteine) activation in NEMO (zeige IKBKG Proteine)-deficient cells is concomitant with RIPK3 (zeige RIPK3 Proteine) recruitment to the apoptosis-mediating complex.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 (zeige CD28 Proteine) and the inflammatory cytokine TNF
MK2 (zeige KCNA2 Proteine)-mediated phosphorylation of RIPK1 (zeige RIPK1 Proteine) serves as a checkpoint within the TNF signaling pathway that integrates cell survival and cytokine production.
TLR4 (zeige TLR4 Proteine) activates CASPASE-8 (zeige CASP8 Proteine) to cleave and remove the deubiquitinase cylindromatosis (CYLD (zeige CYLD Proteine)) in a TRIF (zeige RNF138 Proteine)- and RIPK1 (zeige RIPK1 Proteine)-dependent manner to disable necroptosis in macrophages.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (zeige PDCD4 Proteine)/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (zeige OTX2 Proteine) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (zeige MMP13 Proteine) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (zeige MAMLD1 Proteine) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (zeige IL1B Proteine), IL-8 (zeige IL8 Proteine) and TNF-alpha in porcine alveolar macrophages.
the role of miR (zeige MYLIP Proteine)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (zeige IFNG Proteine), and PGF2a) control expression of MMP1 (zeige MMP1 Proteine), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (zeige TNFRSF1B Proteine) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (zeige PTGES Proteine)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (zeige FAS Proteine) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (zeige SCN9A Proteine) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (zeige NOS2 Proteine) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
The results obtained showed that IL-6 (zeige IL6 Proteine) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (zeige IFNG Proteine) and FASL (zeige FASL Proteine) regulate nitric oxide activity, via eNOS (zeige NOS3 Proteine) expression modulation.
These data show the presence of cytokines TNF and IFNG (zeige IFNG Proteine), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 (zeige IL10 Proteine) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (zeige MMP2 Proteine)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (zeige MAPK8 Proteine) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (zeige IL8 Proteine) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (zeige IL1B Proteine) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (zeige IL1B Proteine) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (zeige VEGFA Proteine) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (zeige TGFB1 Proteine)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (zeige PLAT Proteine) on the vascular compartment
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (zeige CD4 Proteine)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (zeige IL1B Proteine) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
The results reveal a crucial role for TNFalpha/TNFR2 (zeige TNFRSF1B Proteine) axis in the protection of the skin against DUOX1 (zeige DUOX1 Proteine)-mediated oxidative stress.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumour necrosis factor alpha
, putative tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, APC1 protein
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor-necrosis factor
, tumour necrosis factor
, ATP-binding cassette, sub-family F (GCN20), member 1
, TNF alpha
, tumor necrosis factor, alpha