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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820
Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009
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Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826
Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305134
Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989
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Human Tumor Necrosis Factor Protein expressed in Wheat germ - ABIN1323120
Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014
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Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135
Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991
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Human Tumor Necrosis Factor Protein expressed in Yeast (Pichia pastoris) - ABIN988275
Fritz, Radziwill: CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. in Molecular cancer research : MCR 2010
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Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2712390
Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1590232
Hsu, Wang, Tai, Chou, Hsieh, Chiu, Chen, Yang: Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. in Cancer cell 2014
MiR (zeige MLXIP Proteine)-338-3p suppresses the TNF-alpha-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling.
The findings suggest that smoking and the presence of TNFalpha-308 GA/AA genotypes may increase the risk for peri (zeige PLIN1 Proteine)-implantitis, while CD14 (zeige NDUFA2 Proteine)-159 polymorphic CT/TT genotypes decrease the risk.
IL-6 (zeige IL6 Proteine), TNF-alpha and VEGF (zeige VEGFA Proteine) levels in 60 serums, were determined from 30 preoperatively taken from patients with colorectal cancer and 30 from a healthy control group.
ATM (zeige ATM Proteine) could be activated by lung cancer-associated TNF-alpha, up-regulate MMP-13 (zeige MMP13 Proteine) expression and thereby augment tumor metastasis
Serum TNF-alphawas significantly higher and adiponectin was lower in T2DM than healthy controls. Moreover, TNF-alphaG-308A and TNF-alphaG-238ASNPs are not prevalent in this ethnic group [ Pakistani ].
Type 2 diabetic patients with peripheral neuropathy have increased serum TNF-alpha; high level of serum TNF-alpha may be associated with increased risk of peripheral neuropathy independently (Meta-Analysis)
The presence of TNF-alpha-308A allele is associated with increased MMP-9 (zeige MMP9 Proteine) activity in synovial fluid of patients with early rheumatoid arthritis and may be a predictor of rapid radiographic progression of disease.
ALPK1 (zeige ALPK1 Proteine) is a kinase that participates in the regulation of Golgi-derived TNF-alpha trafficking through myosin IIA phosphorylation in the inflammation of gout.
Enhanced thrombin (zeige F2 Proteine) generation is driven in asthma by a systemic inflammatory state mediated by IL-6 (zeige IL6 Proteine) and to a lesser extent TNFalpha, however, not periostin (zeige POSTN Proteine). TNFalpha might contribute to impaired fibrinolysis.
ADAM17 (zeige ADAM17 Proteine) may be a key enzyme that regulates the generation of TNF-alpha in oral keratinocytes.
It is possible that JNK (zeige MAPK8 Proteine) and TNF-alpha commonly contribute to kidney damage by assembling a positive feedback cycle after crush syndrome, leading to increased apoptosis in the renal cortex. HMGB1 (zeige HMGB1 Proteine) from the muscle may be the trigger.
Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF and downstream kinases such as RIPK1 (zeige RIPK1 Proteine).
Taken together, we have demonstrated a role for TNF in the development of classically activated macrophages in listeriosis
Inhibition of signaling stimulated by both TNF and IL1beta (zeige IL1B Proteine) synergizes with NF-kappaB (zeige NFKB1 Proteine) inhibition in eliminating leukemic stem cells.
Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-alpha gene expression and cytokine release in vitro
Results show that interleukin 6 (IL6 (zeige IL6 Proteine)) promotes oval cell proliferation and liver regeneration, while tumor necrosis factor alpha (TNFalpha) and TNF receptor-1(TNFR1 (zeige TNFRSF1A Proteine)) do not affect this process.
This study adds to the evidence that both peripheral and brain region-specific increases in tumor necrosis factor alpha lead to both sickness and depression- and anxiety disorder-relevant behavior and do so via different pathways.
Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A2 (zeige YWHAZ Proteine) via Reactive Oxygen Species in Tumor Necrosis Factor-alpha-Treated Cells.
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta (zeige IL1B Proteine) and IL-6 (zeige IL6 Proteine) mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
aerobic interval training enhanced the anti-inflammatory indices IL-10 (zeige IL10 Proteine)/TNF-alpha ratio and IL-15 (zeige IL15 Proteine) expression in skeletal muscle in tumor-bearing mice.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (zeige IFNG Proteine), and PGF2a) control expression of MMP1 (zeige MMP1 Proteine), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (zeige TNFRSF1B Proteine) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (zeige PTGES Proteine)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (zeige FAS Proteine) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (zeige SCN9A Proteine) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (zeige NOS2 Proteine) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
these findings provide the direct evidence that ADAM17 (zeige ADAM17 Proteine) cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (zeige PDCD4 Proteine)/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (zeige OTX2 Proteine) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (zeige MMP13 Proteine) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (zeige MAMLD1 Proteine) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (zeige IL1B Proteine), IL-8 (zeige IL8 Proteine) and TNF-alpha in porcine alveolar macrophages.
the role of miR (zeige MYLIP Proteine)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG (zeige COL4A1 Proteine)) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2 (zeige TNFRSF1B Proteine))-mediated process.
The results reveal a crucial role for TNFalpha/TNFR2 (zeige TNFRSF1B Proteine) axis in the protection of the skin against DUOX1 (zeige DUOX1 Proteine)-mediated oxidative stress.
proinflammatory cytokines IL-1 (zeige IL1A Proteine)/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB (zeige NFKB1 Proteine)-mediated pathway.
Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.
Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp (zeige AHCY Proteine) larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp (zeige AHCY Proteine) larvae.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (zeige CD4 Proteine)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (zeige IL1B Proteine) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
The results obtained showed that IL-6 (zeige IL6 Proteine) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (zeige IFNG Proteine) and FASL (zeige FASL Proteine) regulate nitric oxide activity, via eNOS (zeige NOS3 Proteine) expression modulation.
These data show the presence of cytokines TNF and IFNG (zeige IFNG Proteine), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 (zeige IL10 Proteine) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (zeige MMP2 Proteine)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (zeige MAPK8 Proteine) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (zeige IL8 Proteine) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (zeige IL1B Proteine) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (zeige IL1B Proteine) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (zeige VEGFA Proteine) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (zeige TGFB1 Proteine)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (zeige PLAT Proteine) on the vascular compartment
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumor-necrosis factor
, tumour necrosis factor
, TNF alpha
, ATP-binding cassette, sub-family F (GCN20), member 1
, tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, tumor necrosis factor, alpha
, Tumor necrosis factor ligand superfamily member 2
, TNF-alpha 1