Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
Show all 9 Pubmed References
Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305134
Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989
Show all 4 Pubmed References
Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820
Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009
Show all 4 Pubmed References
Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826
Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010
Show all 4 Pubmed References
Human Tumor Necrosis Factor Protein expressed in Wheat germ - ABIN1323120
Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014
Show all 3 Pubmed References
Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135
Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991
Show all 3 Pubmed References
Human Tumor Necrosis Factor Protein expressed in Yeast (Pichia pastoris) - ABIN988275
Fritz, Radziwill: CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. in Molecular cancer research : MCR 2010
Show all 2 Pubmed References
Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2712390
Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2007701
Chen, Goeddel: TNF-R1 signaling: a beautiful pathway. in Science (New York, N.Y.) 2002
Show all 6 Pubmed References
The ENAM (zeige ENAM Proteine) and TNF-alpha genes were likely associated with caries occurrence in Chinese children. The ENAM (zeige ENAM Proteine) rs3796703 CT and TNF-alpha rs1800629 AG genotypes might be involved in caries susceptibility and protection, respectively.
The TNF-alpha -308G/A polymorphism was genotyped. Prevalence of the heterozygous mutant (GA) and minor allele (A) were significantly higher in Gastric Cancer cases compared to healthy controls in a Chinese population.
The Fas-ligand (zeige FASL Proteine) SNP and TNF gene -308 SNP are associated with anti-TNF treatment response in Crohn's disease and may help select patients likely to benefit from therapy.
Studied serum Levels of interleukins 6 and 8 (IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine)), tumor necrosis factor(TNF-alpha), and transforming growth factor beta (TGF-beta) in association with chronic hepatitis B patients with depression or anxiety.
Our meta-analysis suggests that the substitution of G to A of TNFalpha -308 G/A polymorphism is a risk factor for oral lichen planus. Its effect exists among mixed populations with mixed hepatitis C vir status. The TNFalpha -308 G/A polymorphism may be a useful genomic marker for oral lichen planus.
TIPE2 (zeige TNFAIP8L2 Proteine) may participate in T2DM by regulating TNF-alpha production
Treg cells from patients with acute hepatitis A produce higher levels of TNF, gain features of T-helper 17 cells, and have reduced suppressive activity. The presence of these cells is associated with severe liver injury.
The 48 juvenile idiopathic arthritis children were 13 systemic, 17 oligoarticular, and 18 polyarticular onset. The serum TNF-alpha was significantly higher in patients compared to control with a tendency to be higher in the polyarticular subtype. All controls had TNF-alpha -308 GG alleles. The frequency of GG genotype tended to be higher in systemic onset compared to oligoarticular and polyarticular subtypes.
correction for individual cytokine expression levels revealed qualitative differences of cytokine profiles characterized by significantly increased TNFalpha and decreased IL-2 (zeige IL2 Proteine)-expressing T-cell proportions in long-term type-1-diabetes patients.
findings highlight an epigenetic mechanism by which EZH2 (zeige EZH2 Proteine) integrates the multifaceted effects of TNFalpha signaling to promote the inflammatory response and apoptosis in colitis.
This study demonstrated that TNF-alpha genetic deletion ameliorates the amyloid phenotype of the 5XFAD mouse model of AD. 5XFAD/TNF-alpha-/- mice exhibit significantly decreased amyloid deposition and reduced levels of AbetaPP-CTFs and amyloid-beta protein.
Data suggest that expression of Tnfa in adipocytes can be regulated by dietary fatty acids; here, polyunsaturated fatty acids regulate Tnfa expression via alteration in methylation of Tnfa promoter in rats fed polyunsaturated fatty acids (safflower oil versus coconut/olive oil) and in mouse adipocyte cell line incubated with polyunsaturated fatty acid (linoleic acid versus palmitic/oleic acids).
a precise mechanism for attenuation of HgCl2-induced liver dysfunction by dietary luteolin via regulating Sirt1 (zeige SIRT1 Proteine)/Nrf2 (zeige NFE2L2 Proteine)/TNF-alpha signaling pathway, and provide a foundation for further study of luteolin as a novel therapeutic agent against inorganic mercury poisoning.
a significant increase in plasma levels of IL-2 (zeige IL2 Proteine), IFN-g (zeige IFNG Proteine) and TNF-a was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
findings suggest that PGRN (zeige GRN Proteine) deficiency leads to excessive NF-kappaB (zeige NFKB1 Proteine) activation in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.
It is possible that JNK (zeige MAPK8 Proteine) and TNF-alpha commonly contribute to kidney damage by assembling a positive feedback cycle after crush syndrome, leading to increased apoptosis in the renal cortex. HMGB1 (zeige HMGB1 Proteine) from the muscle may be the trigger.
Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF and downstream kinases such as RIPK1 (zeige RIPK1 Proteine).
Taken together, we have demonstrated a role for TNF in the development of classically activated macrophages in listeriosis
Inhibition of signaling stimulated by both TNF and IL1beta (zeige IL1B Proteine) synergizes with NF-kappaB (zeige NFKB1 Proteine) inhibition in eliminating leukemic stem cells.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (zeige IFNG Proteine), and PGF2a) control expression of MMP1 (zeige MMP1 Proteine), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (zeige TNFRSF1B Proteine) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (zeige PTGES Proteine)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (zeige FAS Proteine) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (zeige SCN9A Proteine) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (zeige NOS2 Proteine) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
these findings provide the direct evidence that ADAM17 (zeige ADAM17 Proteine) cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (zeige PDCD4 Proteine)/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (zeige OTX2 Proteine) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (zeige MMP13 Proteine) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (zeige MAMLD1 Proteine) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (zeige IL1B Proteine), IL-8 (zeige IL8 Proteine) and TNF-alpha in porcine alveolar macrophages.
the role of miR (zeige MYLIP Proteine)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG (zeige COL4A1 Proteine)) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2 (zeige TNFRSF1B Proteine))-mediated process.
The results reveal a crucial role for TNFalpha/TNFR2 (zeige TNFRSF1B Proteine) axis in the protection of the skin against DUOX1 (zeige DUOX1 Proteine)-mediated oxidative stress.
proinflammatory cytokines IL-1 (zeige IL1A Proteine)/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB (zeige NFKB1 Proteine)-mediated pathway.
Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.
Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp (zeige AHCY Proteine) larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp (zeige AHCY Proteine) larvae.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (zeige CD4 Proteine)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (zeige IL1B Proteine) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
The results obtained showed that IL-6 (zeige IL6 Proteine) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (zeige IFNG Proteine) and FASL (zeige FASL Proteine) regulate nitric oxide activity, via eNOS (zeige NOS3 Proteine) expression modulation.
These data show the presence of cytokines TNF and IFNG (zeige IFNG Proteine), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 (zeige IL10 Proteine) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (zeige MMP2 Proteine)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (zeige MAPK8 Proteine) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (zeige IL8 Proteine) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (zeige IL1B Proteine) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (zeige IL1B Proteine) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (zeige VEGFA Proteine) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (zeige TGFB1 Proteine)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (zeige PLAT Proteine) on the vascular compartment
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumor-necrosis factor
, tumour necrosis factor
, TNF alpha
, ATP-binding cassette, sub-family F (GCN20), member 1
, tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, tumor necrosis factor, alpha
, Tumor necrosis factor ligand superfamily member 2
, TNF-alpha 1