anti-Tumor Necrosis Factor (TNF) Antikörper

Human Tumor Necrosis Factor (TNF) Interaktionspartner

1. the rs361525 variant in the TNF-alpha promoter was associated with the tumor grade in colorectal cancer

2. These data suggest that high umbilical serum testosterone and IL-10 in males could explain reduced TNF-alphalevels and lack of association between vitamin D- dependent innate immunity markers and proinflammatory cytokines expression in the fetoplacental unit.

3. This study could not find any association between TNF-alpha rs361525 and rs1800629 and Parkinson's disease.

4. Genetically determined high activities of the TNF-alpha, IL23/IL17, and NF-kappaB pathways were associated with increased risk of ankylosing spondylitis.

5. The -174 G/G IL-6 genotype increases the risk of developing tuberculosis and type 2 diabetes mellitus comorbidity and this risk is raised when associated with -308G/G TNF-alpha.

6. TNF-alpha genetic polymorphisms could have a role in the development of bronchial asthma among Egyptian children.

7. TNF a-308 and IL-1b polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.

8. this study shows that genetic polymorphisms in tumor necrosis factor alpha are associated with an increased risk of cervical cancer in Chinese women

9. WDR62 coordinates the TNFalpha receptor signaling pathway to JNK activation through association with multiple kinases and the adaptor protein TRAF2.

10. TNFalpha contributes to the aggressive properties of triple negative breast cancer cell lines via upregulation of A20. TNFalpha induces a potent cytotoxic cell death in luminal (ER+) breast cancer cell lines which fail to upregulate A20 expression.

11. One of the novel antibodies generated on the backbone of infliximab, Inf3D6, has the superior binding affinity to TNFalpha, thus, demonstrating the potential for structure guided optimization for improvement of existing antibody-based therapeutics.

12. The second-generation anti-TNF-alpha drugs show increased TNF-a-neutralizing potential compared to first-generation variants. ATI show cross-reactivity toward IFX biosimilar CT-P13 (Inflectra), consequently patients with ATI are unlikely to benefit from treatment with this IFX biosimilar.

13. TREM-1, which has been realized as a proinflammatory receptor protein, can promote the development of periodontitis by regulating the expression of TNF-alpha in macrophages.

14. the association between TNF-alpha-308/ TNF-alpha-238 G>A and the risk of developing severe dengue infection (Meta-Analysis)

15. TNF-alpha can promote periodontal ligament stem cell proliferation and inhibit bone differentiation and Notch signaling pathway expression, indicating that the Notch signaling pathway regulates PDLSCs osteogenic differentiation.

16. higher concentrations of nitric oxide and lower levels of TNF-alpha were observed in the amniotic fluid than in the serum of acute pregnancies, while TGF-beta e INF-gamma levels were similar in both biological material.

17. The aim of the study was to correlate the effects of host cytokine single nucleotide polymorphisms of TNF-alpha (-308 A/G) and IFN-gamma (+874 A/T) in spontaneous or IFN induced treatment response in the hepatitis c cvirus infected thalassemic individuals.

18. The serum levels of TNF-alpha were increased in Parkinson's disease patients compared to those in healthy subjects.

19. Individuals with class III obesity with higher morphological severity of non-alcoholic fatty liver disease exhibited higher BMI and higher IL-6 and TNF-alpha expression in the WAT; future prospective studies are warranted to determine how BMI, IL-6, and TNF-alpha affect the progression of NAFLD in individuals with class III obesity

20. Results provide evidence for a significant association between TNFA rs1799724 and rs361525 polymorphisms and paranoid schizophrenia, at least in the Tunisian population, suggesting a substantially increased risk for paranoid schizophrenia with dominant inheritance of these minor alleles.

Mouse (Murine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. Here the authors have demonstrated that TGF-beta/Smad signaling plays an important role in Laser-induced choroidal neovascularization formation through down-regulation of VEGF and TNF-alpha expressions.

2. These data show that TLR-4 signals are important for the recognition of Sporothrix brasiliensis by macrophages, and their absence promotes the persistence of the infection.

3. These data demonstrate that SIRT1 directly inhibits osteoclastogenesis by inhibiting ROS generation and TRPV1 channel activation under mediation of TNF-alpha.

4. The data of this study do show that blocking of the TNFalpha-driven increase in astrocyte glutamate release can prevent and normalize excitatory synaptic activity in a mouse model of TLE during this latent period

5. TNFalpha in the trigeminal nociceptive system plays a critical role in complete Freund's adjuvant-induced inflammatory temporomandibular joint pain.

6. TNF-alpha-induced MMP-9 secretion from mesothelial cells plays an important role in the metastatic dissemination of gastric cancer.

7. Study provides evidence that TNFalpha is a critical component of hepatic ammonia metabolism. In the brain TNFalpha triggered NKCC1 expression and augmented NH4+ toxicity.

8. constant endothelial activation by transmembrane tumor necrosis factor-alpha (tmTNF-alpha) exacerbates age-induced visual deficits via senescence-mediated ER stress in a transgenic model

9. High TNFA expression is associated with doxorubicin resistant breast cancer.

10. hnRNP K plays a protective role in TNF-alpha-induced apoptosis in podocytes.

11. data show that TNF is an important transcriptional regulator of NLRP3 inflammasome components in murine inflammasomopathies.

12. Restulsshow that peripheral inflammation causes specific molecular changes in the hippocampus of collagen-induced arthritis (CIA) mice, including an upregulation of SERT activity and an increase in TNFalpha signalling. TNFalpha blockade abolished both, CIA-induced anhedonia and the upregulation of SERT activity in etanercept treated mice; behavioural and neurochemical effects in CIA mice are dependent on TNFalpha signa...

13. The results support the notion of a general role of TNF in the inflammatory activation of macrophages.

14. astrocytic TNFalpha levels were higher in GABA-Cnr1-/- mice, indicating that these morphological changes were accompanied by a more pro-inflammatory function. These findings demonstrate that the disruption of endocannabinoid signaling on GABAergic neurons is accompanied by functional changes in astrocyte activity, which are relevant to brain ageing

15. These results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.

16. In addition to highlighting the importance of TNF in CD8(+) T cell- and NK cell-mediated killing of tumor cells, our study also provides a comprehensive picture of the roles of the TNF, IFN, and antigen presentation pathways in immune-mediated tumor surveillance.

17. Tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 were upregulated during BCG infection but downregulated by Rv2346c.

18. Semaphorin3D may contribute to enhanced bone loss by increased TNF-alpha in estrogen deficiency-induced osteoporosis.

19. TNF-alpha induced autophagy in cementoblasts was dependent, or partially dependent on the activity of Stat3 signaling pathway.

20. Although IL-1beta is a proinflammatory cytokine, its effects on aneurysm formation and macrophage polarization differ from TNF-alpha. The differential effects of IL-1beta and TNF-alpha inhibition are related to M1/M2 macrophage polarization

Cow (Bovine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data suggest that luteolytic factors (such as TNFa, interferon gamma, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 mRNA transcription in the embryo.

4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

8. TNF-alpha up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS pathways in the regulation of this pathological condition.

10. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.

11. the effects of lysophopatidic acid on TNFalpha and IFNgamma - induced decrease of progesterone synthesis and on the cytokine - induced apoptosis of the cultured luteal cells.

12. potential DNA markers in the improvement of immunity to mastitis

13. A role for TNFalpha in intervertebral disc degeneration: a non-recoverable catabolic shift.

14. Results indicate that TNF-alpha does not affect autonomous, pulsatile progesterone (P(4)) release, increases P(4) secretion by bovine corpus luteum (CL) with increasing dose & reduces in a dose-dependent manner responsiveness of CL to luteotropic factors.

15. The differences in genetic polymorphism of TNFalpha between dairy dairy cattle herds infected and not infected with the bovine leukemia virus are reported.

16. These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.

17. Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

18. Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.

19. The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.

20. Gene expression changes were observed, but there were no changes in TNFalpha concentrations, which may indicate its local involvement in catabolic adaptation of adipose tissue.

Pig (Porcine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. this study shows of TNF-alpha to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model

2. these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy

3. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.

4. TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes.

5. TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.

6. TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.

7. This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance.

8. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

9. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.

10. the role of miR-181a in adipocyte differentiation by regulation of TNF-alpha

11. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

12. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

13. Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment.

14. In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion.

15. These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-alpha and proteases.

16. We identified critical amino acid residues in PRRSV Nsp1alpha and Nsp1beta that are important for TNF-alpha down-regulation and attenuation in vivo.

17. Porcine reproductive and respiratory syndrome virus infection impaired TNF-alpha production by inhibiting ERK signaling. pathway.

18. Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.

19. These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.

20. Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).

Zebrafish Tumor Necrosis Factor (TNF) Interaktionspartner

1. Macrophage-less irf8 mutants show prolonged inflammation with elevated levels of Tnf-alpha and Il-1beta.

2. Mecp2 is required for tnfa expression during zebrafish development and inflammation.

3. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2)-mediated process.

4. The results reveal a crucial role for TNFalpha/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress.

5. proinflammatory cytokines IL-1/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.

6. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

7. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

8. The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB-mediated pathway.

9. Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.

10. Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp larvae.

11. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

12. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

Rhesus Monkey Tumor Necrosis Factor (TNF) Interaktionspartner

1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

3. Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Horse (Equine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. The results obtained showed that IL-6 expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.

4. These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

5. These results suggest that basal oxidative stress markers, circulating cytokines and anti-inflammatory neuroendocrine hormones appear to correlate with endurance performance in horses.

6. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

7. The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.

Rabbit Tumor Necrosis Factor (TNF) Interaktionspartner

1. TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.

2. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

3. The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

4. The TNFalpha-evoked Cl- current.

5. IL-1beta and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha.

6. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

7. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

8. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1) and TNF-alpha in lung of rabbits.

9. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA on the vascular compartment

Goat Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Cynomolgus Tumor Necrosis Factor (TNF) Interaktionspartner

1. Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.