anti-Tumor Necrosis Factor (TNF) Antikörper

Human Tumor Necrosis Factor (TNF) Interaktionspartner

1. These findings indicate that the let-7e/EZH2/H3K27me3/NF-kappaB p65 pathway is a novel regulatory axis of TNF-alpha expression.

2. This fragmentation is DRP1-independent and might be caused by a deficit of mitochondrial fusion. However, mitochondrial fragmentation does not change neither Brucella replication efficiency, nor the susceptibility of infected cells to TNFalpha-induced apoptosis.

3. The expression of TNF-alpha is increased in intervertebral disc tissue in patients with disc herniation.

4. TNF-alpha promoted PlGF synthesis in BeWo cells and regulated angiogenesis via synergy of the PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

5. TNF-alpha and miR-155 are involved in the pathogenesis of TLE development and that their parallel expression patterns during the phases of temporal lobe epilepsy (TLE) development show an interactive relationship between the two markers, suggesting that miR-155 might play a critical role in the regulation of the neuroinflammatory response during the pathogenesis of TLE.

6. This study suggests an association between TNFalpha polymorphism in the region -308 g/a with susceptibility to tinnitus in individuals with a history of exposure to occupational noise.

7. these two cytokine polymorphisms may play a role in predisposition to coronary heart disease.

8. TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome.

9. Inflammation-induced TNF promotes hepatocellular CCR10 expression and downstream PI3K/Akt-mediated hepatocarcinogenesis.

10. In EGFR-mutant oncogene-addicted cells, blocking TNF enhances the effectiveness of EGFR inhibition. EGFR plus TNF inhibition is also effective in NSCLC with acquired resistance to EGFR inhibition.

11. significantly higher second-trimester amniotic fluid levels in pregnant women with spontaneous preterm birth

12. The proinflammatory cytokine TNF- alpha plays a fundamental role for the maintenance of intestinal homeostasis. Besides inflammation, several studies implicate a role of TNF-alpha signalling during tumour development and also infectious diseases [review]

13. Compared with healthy controls, glomerular expression of TNF was significantly induced in rapidly progressive glomerulonephritis (GN). Within glomeruli immunohistochemistry localized TNF protein expression to endothelial cells and podocytes, with a staining pattern consistent with a cell membrane-associated localization. These findings suggested that membrane TNF may contribute to glomerular injury in GN.

14. the TNF-alpha -308G>A polymorphism plays an important role in celiac disease susceptibility (Meta-Analysis)

15. It is concluded that among pregnant Nigerian women with GDM in this study, increased serum TNF-alpha level is associated with greater insulin resistance independent of age and body mass index

16. Studied association of toll like receptor 4 (TLR4) mRNA levels as well as tumor necrosis factor-alpha (TNF-a) single nucleotide polymorphisms (SNPs) and TLR4 SNPs with preterm birth in a rural Indian population; found increased maternal TLR4 mRNA levels may be associated with the risk of preterm birth.

17. These results indicate that IH stress down-regulates the miR-452 in adipocytes, resulting in increased levels of RETN, TNFalpha, and CCL2 mRNAs, leading to insulin resistance in SAS patients.

18. our data provides a novel insight about the complex interplay between Th17 and Treg subsets in which Th17 cells potentially stimulate the increased frequency of Tregs. This effect is mainly mediated by TNF-alpha-TNFR2 signaling pathway.

19. miR-21 is not linked to expression of the pro-inflammatory cytokine TNF-alpha mRNA, but that miR-21 and TNF-alpha both take part in the cancer expansion at the invasive front of colon cancers.

20. The expression of miR-155 increased in BD and associated with upregulation of TNF-alpha and downregulation of CTLA-4 genes.

Mouse (Murine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. It is shown that TNF-alpha signaling regulates the phosphorylation of serine-5 and -7 in L-plastin which increases the actin bundling capacity of L-plastin and hence the formation of nascent sealing zones in mouse osteoclasts.

2. TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome.

3. TNF-alpha that is intrinsic to muscle and TNF-alpha secreted by immune cells work together to influence muscle aging.

4. Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

5. The present study identifies the critical role of TNF-alpha and mast cells in the host defense against Staphylococcus aureus infection.

6. the effects of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL6) gene knockout in preserving the bone loss induced by ovariectomy, was examined.

7. Investigation of 2-AP demonstrated its nociception inhibition and ability to reduce reactive oxygen species. Its interaction with A2a receptors may well be related to proinflammatory cytokines TNF-alpha and IL-1beta reduction activity, corroborating its antinociceptive effect.

8. Here, we show that TNF-alpha, which is induced by various psychological stresses, induces the p38-dependent phosphorylation of ATF7, a stress-responsive chromatin regulator, in mouse testicular germ cells. This caused a release of ATF7 from the TERRA gene promoter in the subtelomeric region, which disrupted heterochromatin and induced TERRA.

9. Study results demonstrate that transmembrane Tnf is an important mediator of renal tissue damage in mouse nephrotoxic serum nephritis by induction of glomerular and tubulointerstitial cell death, and loss of glomerular endothelial cells and podocyte integrity. NFkB-mediated expression of pro-inflammatory mediators and recruitment of infiltrating leukocytes into nephritic kidney is dependent on the presence of soluble Tnf.

10. miR-1225 is significant in multiple malignancies and other pathological reactions; transfection of a miR-1225 mimic or Keap1 silencing inhibits osteoclastogenesis; after miR-1225 inhibition and Keap1 overexpression, TNF was increased; TNFalpha overexpression promoted Keap1 depletion-inhibited BMM osteoclastogenesis; miR-1225 activates Keap1-Nrf2-HO-1 signal to inhibit TNFalpha-induced osteoclastogenesis

11. TNF-alpha-TNF-Rp55 axis may have essential roles in the resolution of venous thrombus in mice.

12. Macrophage TNF-alpha licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia.

13. Taken together, the authors identified miR-181a-5p a negative regulator in HMGB1-induced immune responses by targeting TNF-alpha mRNA in dendritic cells.

14. Mice overexpression TNF-alpha display significant pelvic pain, voiding dysfunction, urothelial lesions, and sensory input.

15. results suggest that blood entering the joint activates the iRhom2/ADAM17/TNF-alpha pathway, thereby contributing to osteopenia and synovitis in mice.

16. The level of TNF-alpha in murine macrophages was dependent on the applied concentration of sericin, and the expression of genes associated with osteogenesis in osteoblast-like cells was dependent on the applied concentration of TNF-a

17. this study shows that TNF-alpha-driven dendritic cell activation limits lipopolysaccharide-induced protection from allergic inflammation in infant mice

18. In conclusion, these data provide evidence for a regulatory role of TNF-alpha in diesel exhaust particles-induced pulmonary inflammation and identify TNFR2 as the most important receptor in mediating these inflammatory effects.

19. DUSP5 functions in the feedback inhibition of ERK1/2 signaling in response to TNFalpha, which resulted in increased inflammatory gene expression.

20. our data indicates that Bgn and Fmod expressed by the bone forming cells, are novel coupling ECM components that control bone mass through sequestration of TNFalpha and/or RANKL, thereby adjusting their bioavailability in order to regulate osteoclastogenesis.

Cow (Bovine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data suggest that luteolytic factors (such as TNFa, interferon gamma, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 mRNA transcription in the embryo.

4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

8. TNF-alpha up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS pathways in the regulation of this pathological condition.

10. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.

11. the effects of lysophopatidic acid on TNFalpha and IFNgamma - induced decrease of progesterone synthesis and on the cytokine - induced apoptosis of the cultured luteal cells.

12. potential DNA markers in the improvement of immunity to mastitis

13. A role for TNFalpha in intervertebral disc degeneration: a non-recoverable catabolic shift.

14. Results indicate that TNF-alpha does not affect autonomous, pulsatile progesterone (P(4)) release, increases P(4) secretion by bovine corpus luteum (CL) with increasing dose & reduces in a dose-dependent manner responsiveness of CL to luteotropic factors.

15. The differences in genetic polymorphism of TNFalpha between dairy dairy cattle herds infected and not infected with the bovine leukemia virus are reported.

16. These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.

17. Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

18. Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.

19. The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.

20. Gene expression changes were observed, but there were no changes in TNFalpha concentrations, which may indicate its local involvement in catabolic adaptation of adipose tissue.

Pig (Porcine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. The present study showed that TNF-alpha, which was secreted by the tracheal epithelial cells when they were stimulated with several swine pathogens, damaged tight junction proteins and disrupted the epithelial barrier of a pig tracheal epithelial cell model.

2. Mechanistically, Porcine productive and respiratory syndrome virus induced an elevated level of tumor necrosis factor (TNF-alpha), through the nuclear factor kappaB (NF-kappaB) signaling pathway to inhibit the replication of classical swine fever virus -C in vitro.

3. this study shows of TNF-alpha to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model

4. these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy

5. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.

6. TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes.

7. TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.

8. TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.

9. This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance.

10. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

11. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.

12. the role of miR-181a in adipocyte differentiation by regulation of TNF-alpha

13. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

14. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

15. Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment.

16. In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion.

17. These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-alpha and proteases.

18. We identified critical amino acid residues in PRRSV Nsp1alpha and Nsp1beta that are important for TNF-alpha down-regulation and attenuation in vivo.

19. Porcine reproductive and respiratory syndrome virus infection impaired TNF-alpha production by inhibiting ERK signaling. pathway.

20. Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.

Zebrafish Tumor Necrosis Factor (TNF) Interaktionspartner

1. Macrophage-less irf8 mutants show prolonged inflammation with elevated levels of Tnf-alpha and Il-1beta.

2. Mecp2 is required for tnfa expression during zebrafish development and inflammation.

3. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2)-mediated process.

4. The results reveal a crucial role for TNFalpha/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress.

5. proinflammatory cytokines IL-1/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.

6. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

7. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

8. The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB-mediated pathway.

9. Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.

10. Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp larvae.

11. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

12. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

Rhesus Monkey Tumor Necrosis Factor (TNF) Interaktionspartner

1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

3. Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Horse (Equine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. The results obtained showed that IL-6 expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.

4. These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

5. These results suggest that basal oxidative stress markers, circulating cytokines and anti-inflammatory neuroendocrine hormones appear to correlate with endurance performance in horses.

6. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

7. The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.

Rabbit Tumor Necrosis Factor (TNF) Interaktionspartner

1. TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.

2. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

3. The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

4. The TNFalpha-evoked Cl- current.

5. IL-1beta and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha.

6. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

7. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

8. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1) and TNF-alpha in lung of rabbits.

9. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA on the vascular compartment

Goat Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Cynomolgus Tumor Necrosis Factor (TNF) Interaktionspartner

1. Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.