anti-Tumor Necrosis Factor (TNF) Antikörper

Human Tumor Necrosis Factor (TNF) Interaktionspartner

1. TNF reduced PHEX expression in osteosarcoma cell line. Activation of the NF-kappaB pathway by TNF was manifested as a nuclear increase in RELA and NFKB1 heterodimer.

2. This meta-analysis suggested that TNF-a gene -308 G/A polymorphism is associated with increased silicosis and coal workers pneumoconiosis risk in the Chinese population

3. TNF-alpha -308 G > A allele A and GA genotype were found to result in higher risks of developing irritable bowel syndrome (IBS) in children, and TNF-alpha -238 G > A allele A and AA genotype increase the risk for IBS

4. Depletion of human IKK1, IKK2 or IKK1/2 leads to strongly impaired NF-kappaB activation. Only IKK1/2 double-deficient cells are sensitized to TNF-alpha induced cell death. Cell death is mediated independently on NF-kappaB via RIPK1.

5. Neither the PPARgamma nor the IRS-1 polymorphism was associated with mortality outcome in breast-cancer patients. The TNF-alfa -308 G > A polymorphism was associated with reduced breast-cancer-specific and all-cause mortality.

6. Symptomatic chagasic patients were differentiated from asymptomatic patients based on the expression of CD154 and membrane TNF-alpha in TCD4+ and TCD8+ compartments, respectively.

7. High TNFA expression is associated with doxorubicin resistant breast cancer.

8. TNF-alpha rs1800629 polymorphism was significantly associated with the susceptibility of dilated cardiomyopathy for Asians (Meta-Analysis)

9. circulating LBP plasma concentration and hs-CRP were significantly increased in subjects with homeostatic model assessment of insulin resistance (HOMA-IR) >/=2.6 when compared with those with HOMA-IR<2.6 (P<.0001); there was no difference in TNF-alpha or IL-6 concentrations between groups

10. TNF-alpha and IFN-gamma modulate the secretion of chemokines in ESCs independently of Fas-induced apoptosis. These results suggest a constant response pattern on pro-inflammatory cytokines within the population of human ESCs.

11. The TNF-alpha -308G/A polymorphism is associated with TNF-alpha levels in Indian population, which might have implications for clinical risk stratification and treatment

12. Patients with infectious complications posttransplantation have lower CD14CD16 monocyte secretion of TNF-alpha in to Epstein-Barr virus peptides.

13. The rs1800750 polymorphism was significantly associated with severity in Colombian dengue hemorrhagic fever patients.

14. endogenous IgG levels remained above 8g/L in patients with highly indolent chronic lymphocytic leukemia (n=25) and TNFalpha and beta-2-microglobulin (beta2M) in blood decreased when immunoglobulin replacement therapy was used to increase IgG levels over 9g/L.

15. When conditioned media was immuno-depleted of Hsp60, there was a significant reduction in the release of TNF-alpha from the human umbilical vein endothelial cells.

16. TNF-alpha increased the enzymatic activities of urokinase and protein kinase C alpha. TNF-alpha increased matrix metalloproteinase-2 activity and blood-brain barrier leakage.

17. IL-10 suppresses TNF-alpha-induced expression of human aromatase gene in mammary adipose tissue.

18. viability via blocking cell cycle and progressing apoptosis. The apoptosis was partially dependent upon caspase-8 concomitant with attenuated NF-kappa B survival signal due to stimulus of TNF-alpha. It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-kappa B survival signals induced by TNF-alpha in hepatocarcinoma cells.

19. in patients with coronary artery disease and without acute myocardial infarction leptin may represent a potential mechanism of adverse cardiac remodeling. Resistin and TNF-alpha might not be involved in ventricular remodeling in these patients.

20. Programmed cell death 1 ligand 1 protein (PD-L1) expression was typically high in in pancreatic ductal adenocarcinoma (PDAC) patients with high tumor necrosis factor (TNF)-alpha mRNA levels.

Mouse (Murine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. TNF-alpha-induced MMP-9 secretion from mesothelial cells plays an important role in the metastatic dissemination of gastric cancer.

2. Study provides evidence that TNFalpha is a critical component of hepatic ammonia metabolism. In the brain TNFalpha triggered NKCC1 expression and augmented NH4+ toxicity.

3. constant endothelial activation by transmembrane tumor necrosis factor-alpha (tmTNF-alpha) exacerbates age-induced visual deficits via senescence-mediated ER stress in a transgenic model

4. High TNFA expression is associated with doxorubicin resistant breast cancer.

5. hnRNP K plays a protective role in TNF-alpha-induced apoptosis in podocytes.

6. data show that TNF is an important transcriptional regulator of NLRP3 inflammasome components in murine inflammasomopathies.

7. Restulsshow that peripheral inflammation causes specific molecular changes in the hippocampus of collagen-induced arthritis (CIA) mice, including an upregulation of SERT activity and an increase in TNFalpha signalling. TNFalpha blockade abolished both, CIA-induced anhedonia and the upregulation of SERT activity in etanercept treated mice; behavioural and neurochemical effects in CIA mice are dependent on TNFalpha signa...

8. The results support the notion of a general role of TNF in the inflammatory activation of macrophages.

9. astrocytic TNFalpha levels were higher in GABA-Cnr1-/- mice, indicating that these morphological changes were accompanied by a more pro-inflammatory function. These findings demonstrate that the disruption of endocannabinoid signaling on GABAergic neurons is accompanied by functional changes in astrocyte activity, which are relevant to brain ageing

10. These results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.

11. In addition to highlighting the importance of TNF in CD8(+) T cell- and NK cell-mediated killing of tumor cells, our study also provides a comprehensive picture of the roles of the TNF, IFN, and antigen presentation pathways in immune-mediated tumor surveillance.

12. Tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 were upregulated during BCG infection but downregulated by Rv2346c.

13. Semaphorin3D may contribute to enhanced bone loss by increased TNF-alpha in estrogen deficiency-induced osteoporosis.

14. TNF-alpha induced autophagy in cementoblasts was dependent, or partially dependent on the activity of Stat3 signaling pathway.

15. Although IL-1beta is a proinflammatory cytokine, its effects on aneurysm formation and macrophage polarization differ from TNF-alpha. The differential effects of IL-1beta and TNF-alpha inhibition are related to M1/M2 macrophage polarization

16. Following Unfolded Protein Response activation during autosomal dominant retinitis pigmentosa progression, secrete TNFalpha and signal a self-destructive program to the cones, resulting in their cell death.

17. In a hypercaloric environment, persistent elevation of microglial reactivity and consequent TNFalpha secretion induces mitochondrial stress in POMC neurons that contributes to the development of obesity. Specific disruption of the gene expressions of TNFalpha downstream signals TNFSF11A or NDUFAB1 in the mediobasal hypothalamus of diet-induced obese mice reverses mitochondrial elongation and reduces obesity.

18. persistent stimulation with titanium particles may lead to a consistent release of TNF-alpha and IL-6 via SPHK-2 activity, which may lead to aseptic implant loosening

19. Recognition memory improved with exercise in WT mice, was impaired in TNFR1(-/-) exercise mice, showed non-significant impairment with exercise in TNF(-/-) mice, and no changes in TNFR2(-/-) mice. In spatial learning there were exercise related improvements in WT mice, non-significant but meaningful impairments evident in TNFR1(-/-) exercise mice, modest improvement in TNF(-/-) exercise mice.

20. In vitro mild uncoupling rescued from TNF-induced endothelial permeability, disassembly of cell contacts and VE-cadherin cleavage by the matrix metalloprotease 9 (capital EM, Cyrilliccapital EM, Cyrilliccapital ER, Cyrillic9). The uncouplers prevented TNF-induced expression of MMP9 via inhibition of NFkappaB signaling.

Cow (Bovine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data suggest that luteolytic factors (such as TNFa, interferon gamma, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 mRNA transcription in the embryo.

4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

8. TNF-alpha up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS pathways in the regulation of this pathological condition.

10. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.

11. the effects of lysophopatidic acid on TNFalpha and IFNgamma - induced decrease of progesterone synthesis and on the cytokine - induced apoptosis of the cultured luteal cells.

12. potential DNA markers in the improvement of immunity to mastitis

13. A role for TNFalpha in intervertebral disc degeneration: a non-recoverable catabolic shift.

14. Results indicate that TNF-alpha does not affect autonomous, pulsatile progesterone (P(4)) release, increases P(4) secretion by bovine corpus luteum (CL) with increasing dose & reduces in a dose-dependent manner responsiveness of CL to luteotropic factors.

15. The differences in genetic polymorphism of TNFalpha between dairy dairy cattle herds infected and not infected with the bovine leukemia virus are reported.

16. These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.

17. Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

18. Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.

19. The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.

20. Gene expression changes were observed, but there were no changes in TNFalpha concentrations, which may indicate its local involvement in catabolic adaptation of adipose tissue.

Pig (Porcine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy

2. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.

3. TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes.

4. TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.

5. TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.

6. This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance.

7. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

8. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.

9. the role of miR-181a in adipocyte differentiation by regulation of TNF-alpha

10. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

11. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

12. Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment.

13. In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion.

14. These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-alpha and proteases.

15. We identified critical amino acid residues in PRRSV Nsp1alpha and Nsp1beta that are important for TNF-alpha down-regulation and attenuation in vivo.

16. Porcine reproductive and respiratory syndrome virus infection impaired TNF-alpha production by inhibiting ERK signaling. pathway.

17. Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.

18. These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.

19. Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).

20. increased plasma levels during recovery from cardiac arrest are associated with left ventricle dysfunction

Zebrafish Tumor Necrosis Factor (TNF) Interaktionspartner

1. Mecp2 is required for tnfa expression during zebrafish development and inflammation.

2. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2)-mediated process.

3. The results reveal a crucial role for TNFalpha/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress.

4. proinflammatory cytokines IL-1/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.

5. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

6. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

7. The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB-mediated pathway.

8. Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.

9. Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp larvae.

10. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

11. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

Rhesus Monkey Tumor Necrosis Factor (TNF) Interaktionspartner

1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

3. Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Horse (Equine) Tumor Necrosis Factor (TNF) Interaktionspartner

1. The results obtained showed that IL-6 expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.

4. These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

5. These results suggest that basal oxidative stress markers, circulating cytokines and anti-inflammatory neuroendocrine hormones appear to correlate with endurance performance in horses.

6. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

7. The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.

Rabbit Tumor Necrosis Factor (TNF) Interaktionspartner

1. TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.

2. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

3. The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

4. The TNFalpha-evoked Cl- current.

5. IL-1beta and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha.

6. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

7. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

8. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1) and TNF-alpha in lung of rabbits.

9. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA on the vascular compartment

Goat Tumor Necrosis Factor (TNF) Interaktionspartner

1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Cynomolgus Tumor Necrosis Factor (TNF) Interaktionspartner

1. Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.