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Human Polyclonal TRAF6 Primary Antibody für WB - ABIN1881900
Hinz, Stilmann, Arslan, Khanna, Dittmar, Scheidereit: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. in Molecular cell 2010
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Human Polyclonal TRAF6 Primary Antibody für ICC, ELISA - ABIN1003297
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Cow (Bovine) Polyclonal TRAF6 Primary Antibody für IHC (fro), IHC (p) - ABIN537432
Ichii, Otsuka, Sasaki, Namiki, Hashimoto, Kon: Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. in Kidney international 2012
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Human Polyclonal TRAF6 Primary Antibody für FACS, WB - ABIN4361690
Yoshida, Jono, Kai, Li: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. in The Journal of biological chemistry 2005
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Human Polyclonal TRAF6 Primary Antibody für ICC, IHC (fro) - ABIN3044469
Yuan, Zhang, Yang: Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats. in Evidence-based complementary and alternative medicine : eCAM 2014
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Human Polyclonal TRAF6 Primary Antibody für IF (p) - ABIN918441
Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. in Journal of experimental & clinical cancer research : CR 2017
Human Polyclonal TRAF6 Primary Antibody für IF (p), IHC (p) - ABIN738906
Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. in Scientific reports 2017
Cow (Bovine) Polyclonal TRAF6 Primary Antibody für IHC, IHC (p) - ABIN4361692
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Human Polyclonal TRAF6 Primary Antibody für ELISA, ICC - ABIN4361694
Doyon, Servant et al.: Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase ... in The Journal of biological chemistry 2010
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (zeige MAPK8 Antikörper) activity by dissociating Atg9 (zeige ATG9A Antikörper)/mAtg9 (zeige ATG9A Antikörper) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
Data indicate TNF receptor associated factor 6 (TRAF6) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1 (zeige MAP3K7 Antikörper)), -dependent manner.
Berberine hydrochloride targets TRAF6 and NFATc1 (zeige NFATC1 Antikörper).
protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.
The authors found that keratin 8 (zeige KRT8 Antikörper) suppressed toll (zeige TLR4 Antikörper)-like receptor-induced nuclear factor (NF)-kappaB (zeige NFKB1 Antikörper) activation and interacted with the adaptor tumor necrosis factor (TNF (zeige TNF Antikörper)) receptor-associated factor 6 (TRAF6) to prevent its polyubiquitination.
MiR (zeige MLXIP Antikörper)-146a/ MiR (zeige MLXIP Antikörper)-146b could down-regulate the TRAF6 and IRAK1 (zeige IRAK1 Antikörper) expression and promote proliferation, migration and angiogenesis ability of endothelial progenitor cells, which could be important for recovery of patients with hyperacute ischemic stroke.
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (zeige UBE2N Antikörper)/Ub~Ubc13 (zeige UBE2N Antikörper) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 (zeige WDFY3 Antikörper) and the RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA (zeige PCNA Antikörper)- and ATM (zeige ATM Antikörper)/ATR (zeige ATR Antikörper)-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
our data demonstrated that miR146b5p, as a tumor suppressor, mediated temozolomide resistance in GBM cells through negatively regulating TRAF6 expression, indicating that miR146b5p and its targeted genes would be potential therapeutic targets for glioma therapy.
genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (zeige NLRX1 Antikörper) (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (zeige NLRX1 Antikörper) (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (NLRX1 (zeige NLRX1 Antikörper) = NLR family member-X1 (zeige NLRX1 Antikörper))
miR (zeige MLXIP Antikörper)-146a suppresses the inflammatory response in human white adipocytes via targeting the expression of IRAK1 (zeige IRAK1 Antikörper) and TRAF6.
miRNA146a expression was significantly higher in hepatitis C patients with a best cut off value 1.63 to discriminate between hepatitis C patients and healthy controls. Meanwhile, it was negatively correlated to IRAK1 (zeige IRAK1 Antikörper) and TRAF6 levels and positively correlated to viral load in hepatitis C patients.
Suggest role for EBV-EBER1 in the induction of increased TRAF6 expression in the peripheral B cells of Sjogren's patients.
theses results indicate that miR (zeige MLXIP Antikörper)-146b-5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting TRAF6 mediated Akt (zeige AKT1 Antikörper) phosphorylation
TRAF6 plays direct roles in the pro-inflammatory effects and proliferation of Rheumatoid arthritis (RA) fibroblast-like synoviocytes. TRAF6 may serve as a potential treatment target in RA.
MiR (zeige MLXIP Antikörper)-146a declined, while TRAF6 increased in lupus nephritis patients compared with healthy controls.
Epigallocatechin-3-gallate is a novel E3 ubiquitin ligase (zeige MUL1 Antikörper) inhibitor that could be used to target TRAF6 activity in melanoma cells, inhibiting cell proliferation/migration.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6