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anti-Mouse (Murine) TRAF6 Antikörper:
anti-Human TRAF6 Antikörper:
anti-Rat (Rattus) TRAF6 Antikörper:
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Human Polyclonal TRAF6 Primary Antibody für WB - ABIN1881900
Hinz, Stilmann, Arslan, Khanna, Dittmar, Scheidereit: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. in Molecular cell 2010
Show all 4 Pubmed References
Human Polyclonal TRAF6 Primary Antibody für ICC, ELISA - ABIN1003297
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Cow (Bovine) Polyclonal TRAF6 Primary Antibody für IHC (fro), IHC (p) - ABIN537432
Ichii, Otsuka, Sasaki, Namiki, Hashimoto, Kon: Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. in Kidney international 2012
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Human Polyclonal TRAF6 Primary Antibody für FACS, WB - ABIN4361690
Yoshida, Jono, Kai, Li: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. in The Journal of biological chemistry 2005
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Human Polyclonal TRAF6 Primary Antibody für ICC, IHC (fro) - ABIN3044469
Yuan, Zhang, Yang: Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats. in Evidence-based complementary and alternative medicine : eCAM 2014
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Human Polyclonal TRAF6 Primary Antibody für IF (p) - ABIN918441
Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. in Journal of experimental & clinical cancer research : CR 2017
Human Polyclonal TRAF6 Primary Antibody für IF (p), IHC (p) - ABIN738906
Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. in Scientific reports 2017
Cow (Bovine) Polyclonal TRAF6 Primary Antibody für IHC, IHC (p) - ABIN4361692
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Human Polyclonal TRAF6 Primary Antibody für ELISA, ICC - ABIN4361694
Doyon, Servant et al.: Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase ... in The Journal of biological chemistry 2010
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (zeige MAPK8 Antikörper) activity by dissociating Atg9 (zeige ATG9A Antikörper)/mAtg9 (zeige ATG9A Antikörper) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (zeige UBE2N Antikörper)/Ub~Ubc13 (zeige UBE2N Antikörper) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 (zeige WDFY3 Antikörper) and the RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (zeige NLRP3 Antikörper) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA (zeige PCNA Antikörper)- and ATM (zeige ATM Antikörper)/ATR (zeige ATR Antikörper)-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (zeige TP53 Antikörper) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (zeige TP53 Antikörper) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 (zeige MYO15 Antikörper) domain of STAT3 (zeige STAT3 Antikörper), which is an essential step for STAT3 (zeige STAT3 Antikörper) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (zeige CUL5 Antikörper) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (zeige TNFSF11 Antikörper) enhances TNF (zeige TNF Antikörper)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (zeige TRAF3 Antikörper), a known inhibitor of osteoclastogenesis. (RANKL (zeige TNFSF11 Antikörper) = osteoclast differentiation factor (zeige TNFSF11 Antikörper); TNF (zeige TNF Antikörper) = tumor necrosis factor (zeige TNF Antikörper); Traf (zeige TRAF1 Antikörper) = TNF (zeige TNF Antikörper) receptor-associated factor)
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Epigallocatechin-3-gallate is a novel E3 ubiquitin ligase (zeige MUL1 Antikörper) inhibitor that could be used to target TRAF6 activity in melanoma cells, inhibiting cell proliferation/migration.
Results identified TRAF6 as a direct target of miR (zeige MLXIP Antikörper)-429, and its downregulation partially attenuates the effect of miR (zeige MLXIP Antikörper)-429 in promoting hepatocellular carcinoma cell proliferation and motility.
Compared with normal chondrocytes, the expression of miR (zeige MLXIP Antikörper)-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-kappaB (zeige NFKB1 Antikörper) increased in osteoarthritis chondrocytes.
We report two siblings with SCID (zeige PRKDC Antikörper) and an atypical phenotype of osteopetrosis (OP (zeige CSF1 Antikörper)). A biallelic microdeletion encompassing the 5' region of TRAF6, RAG1 (zeige RAG1 Antikörper) and RAG2 (zeige RAG2 Antikörper) genes was identified. TRAF6, a tumor necrosis factor (zeige TNF Antikörper) receptor-associated family member, plays an important role in T cell signaling and in RANKL (zeige TNFSF11 Antikörper)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported
miR (zeige MLXIP Antikörper)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4 (zeige TLR4 Antikörper), TRAF6, and p-IkappaBalpha (zeige NFKBIA Antikörper), subsequently leading to decreased NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige GORASP1 Antikörper) nuclear translocation.
Taken together, these results define a novel role for miR (zeige MLXIP Antikörper)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (zeige YOD1 Antikörper) antagonizes TRAF6/p62 (zeige GTF2H1 Antikörper)-dependent IL-1 (zeige IL1A Antikörper) signaling to NF-kappaB (zeige NFKB1 Antikörper).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (zeige CRBN Antikörper) negatively regulates TLR4 (zeige TLR4 Antikörper) signaling via attenuation of TRAF6 and TAB2 (zeige TAB2 Antikörper) ubiquitination.
the polymorphisms in TLR-MyD88 (zeige MYD88 Antikörper)-NF-kappaB (zeige NFKB1 Antikörper) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6