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TRAF2 functions as an important modulator in tumor metastasis and tumor microenvironment formation and is a novel independent prognostic factor of gastric cancer.
High expression of TRAF2 can predict poorer prognosis of GBM and was identified as an independent biomarker in GBM prognosis.
TRAF2 can influence in vitro growth of TRAIL-treated DU-145 cells at least partially via regulating SIRT1 (zeige SIRT1 Proteine) expression.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta (zeige PRKCZ Proteine). Pretreatment with the PKCzeta (zeige PRKCZ Proteine) activator phosphatidylcholine (zeige SGMS2 Proteine) remarkably attenuated gut (zeige GUSB Proteine) injury by suppressing apoptosis. H/R induced PKCzeta (zeige PRKCZ Proteine) to combine with TRAF2, which was phosphorylated by PKCzeta (zeige PRKCZ Proteine) at Ser (zeige SIGLEC1 Proteine)(55), but not at Ser (zeige SIGLEC1 Proteine)(11), under intestinal I/R or H/R conditions
In conclusion, for the first time, we report that TRADD (zeige TRADD Proteine), TRAF2, RIP1 (zeige UQCRFS1 Proteine) and TAK1 (zeige MAP3K7 Proteine) play a role in the regulating TNF-alpha (zeige TNF Proteine) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (zeige TNF Proteine) in the processes of human labour and delivery.
Both S1P (zeige MBTPS1 Proteine) and caspase-8 (zeige CASP8 Proteine) are critical for TRAF2 stabilization, polyubiquitination, subsequent activation of JNK (zeige MAPK8 Proteine)/AP1 (zeige FOSB Proteine) signaling and MMP1 (zeige MMP1 Proteine) expression and final promotion of cell invasion.
Results showed that high expression of TRAF2 was significantly associated with tumor stage of prostate cancer.
The addition of nanomolar concentration of TRAF2 in GUVs also seems to exert a mechanical action.
TRAF2 and OTUD7B (zeige OTUD7B Proteine) govern a ubiquitin-dependent switch that regulates mTORC2 (zeige CRTC2 Proteine) signalling
destabilization of TRAF2 by miR-17 reduced the ability of TRAF2 to associate with cIAP2 (zeige BIRC3 Proteine), resulting in the downregulation of TNF-alpha (zeige TNF Proteine)-induced NF-kappaBp65, c-Jun (zeige JUN Proteine), and STAT3 (zeige STAT3 Proteine) nuclear translocation and the production of IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), MMP-1 (zeige MMP1 Proteine), and MMP-13 (zeige MMP13 Proteine) in human rheumatoid arthritis synovial fibroblasts.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA (zeige PCNA Proteine)- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.
Traf2 mediates the pro-survival pathway in the heart by suppressing necroptotic signaling.
Targeting TRAF2 may be useful as a therapeutic approach for immunosuppression-free islet allograft survival that avoids the thromboembolic complications associated with the use of anti-CD40L (zeige CD40LG Proteine) antibodies.
Celastrol promotes Nur77 (zeige NR4A1 Proteine) migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2. Ubiquitinated Nur77 (zeige NR4A1 Proteine) then interacts with p62/SQSTM1 (zeige SQSTM1 Proteine), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
this study shows that TRAF2 and TRAF5 (zeige TRAF5 Proteine) work as important regulators of the IL-6R signaling needed for Th17 development
Keratinocyte-specific deletion of Traf2, but not Sphk1 (zeige SPHK1 Proteine) deficiency, disrupted TNF (zeige TNF Proteine) mediated NF-kappaB (zeige NFKB1 Proteine) and MAP kinase (zeige MAPK1 Proteine) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
TRAF2 functions as a key activator of MST1 (zeige MST1 Proteine) in oxidative stress-induced (zeige SQSTM1 Proteine) intracellular signaling processes.
Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
, conjugal transfer protein TraF
, E3 ubiquitin-protein ligase TRAF2
, tumor necrosis factor type 2 receptor associated protein 3
, tumor necrosis factor type 2 receptor-associated protein 3
, TRAF family member-associated NFKB activator
, TNF receptor-associated factor 2