RIPK1 Proteine (RIPK1)

Human Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

1. The caspase 8 mediated RIPK1 cleavage product has a pro-apoptotic function, and further cleavage of this pro-apoptotic cleavage product by human rhinovirus 3C protease may provide a mechanism by which human rhinovirus limits apoptosis.

2. The major function of RIP1 kinase activity in TNF-induced necroptosis is to autophosphorylate serine 161. This specific phosphorylation then enables RIP1 to recruit RIP3 and form a functional necrosome, a central controller of necroptosis.

3. In lesional psoriatic epidermis, RIPK1-expression was decreased compared with that in normal epidermis. RIPK1-knockdown enhanced TRAIL-mediated expression of psoriasis-relating cytokines in normal human epidermal keratinocytes.

4. RIPK1 plays a critical role in the human immune system.

5. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

6. RIPK1-DD has a role in mediating RIPK1 dimerization and activation of its kinase activity during necroptosis and RIPK1-dependent apoptosis

7. We further identified this underlying mechanism also involved a PPARgamma-induced ANXA1-dependent autoubiquitination of cIAP1, the direct E3 ligase of RIP1, shifting cIAP1 toward proteosomal degradation..our study provides first insight for the suitability of using drug-induced expression of ANXA1 as a new player in RIP1-induced death machinery in triple-negative breast cancer

8. data suggest that artesunate could induce RIP1-dependent cell death in human renal carcinoma.

9. RIP1 has a role in CD40-mediated activation of caspase-8, which in turn leads to induction of apoptosis

10. High RIPK1 expression is associated with Alzheimer's disease.

11. These data represent the first report of decreased RIPK1 expression in neutrophils of Systemic Lupus Erythematosus patients and imply that RIPK1 may be involved in neutrophil death and neutrophil extracellular traps formation.

12. Data indicate that receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) polymorphism is a prognostic biomarker for tumor development and survival of hepatocellular carcinoma (HCC) patients after hepatectomy.

13. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.

14. Existence of a kinase-independent role of nuclear RIPK1 in the regulation of PARP1.

15. Study identify and quantify over 8,000 phosphorylated peptides, among which are numerous known sites in the TNF-RSC, NFkappaB, and MAP kinase signaling systems. Functional analysis of S320 phosphorylation in RIPK1 demonstrates a role for this event in suppressing its kinase activity, association with CASPASE-8 and FADD proteins, and subsequent necrotic cell death during inflammatory TNFalpha stimulation.

16. New potent RIPK1 inhibitors are reported (GSK2606414 and GSK2656157).

17. In conclusion, for the first time, we report that TRADD, TRAF2, RIP1 and TAK1 play a role in the regulating TNF-alpha signalling in human myometrium. These findings are of significance given the central role of TNF-alpha in the processes of human labour and delivery.

18. the in vivo effects were diametrically reversed with RIP3 deletion or RIP1 blockade, resulting in marked tumor protection. The dichotomy between the in vivo and in vitro results suggests that the microenvironmental milieu resulting from RIP1/RIP3 signaling is likely responsible for its protumorigenic effects

19. Shikonin induces glioma cell necroptosis in vitro by reactive oxygen species overproduction and promoting RIP1/RIP3 necrosome formation.

20. the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.

Xenopus laevis Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

1. Interaction of xFADD and xRIP1 induced synergistic activation of JNK and NF-kappaB.