RIPK1 Proteine (RIPK1)

Human Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

1. We further identified this underlying mechanism also involved a PPARgamma (zeige PPARG Proteine)-induced ANXA1 (zeige ANXA1 Proteine)-dependent autoubiquitination of cIAP1 (zeige BIRC2 Proteine), the direct E3 ligase of RIP1 (zeige UQCRFS1 Proteine), shifting cIAP1 (zeige BIRC2 Proteine) toward proteosomal degradation..our study provides first insight for the suitability of using drug-induced expression of ANXA1 (zeige ANXA1 Proteine) as a new player in RIP1 (zeige UQCRFS1 Proteine)-induced death machinery in triple-negative breast cancer

2. data suggest that artesunate could induce RIP1-dependent cell death in human renal carcinoma.

3. RIP1 (zeige UQCRFS1 Proteine) has a role in CD40 (zeige CD40 Proteine)-mediated activation of caspase-8 (zeige CASP8 Proteine), which in turn leads to induction of apoptosis

4. High RIPK1 expression is associated with Alzheimer's disease.

5. These data represent the first report of decreased RIPK1 expression in neutrophils of Systemic Lupus Erythematosus patients and imply that RIPK1 may be involved in neutrophil death and neutrophil extracellular traps formation.

6. Data indicate that receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) polymorphism is a prognostic biomarker for tumor development and survival of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients after hepatectomy.

7. we found that ORF3 protein downregulates TLR3 (zeige TLR3 Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) signaling via TRADD (zeige TRADD Proteine) and RIP1 (zeige UQCRFS1 Proteine). Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.

8. Existence of a kinase-independent role of nuclear RIPK1 in the regulation of PARP1 (zeige PARP1 Proteine).

9. Study identify and quantify over 8,000 phosphorylated peptides, among which are numerous known sites in the TNF (zeige TNF Proteine)-RSC, NFkappaB (zeige NFKB1 Proteine), and MAP kinase (zeige MAPK1 Proteine) signaling systems. Functional analysis of S320 phosphorylation in RIPK1 demonstrates a role for this event in suppressing its kinase activity, association with CASPASE-8 (zeige CASP8 Proteine) and FADD (zeige FADD Proteine) proteins, and subsequent necrotic cell death during inflammatory TNFalpha (zeige TNF Proteine) stimulation.

10. New potent RIPK1 inhibitors are reported (GSK2606414 and GSK2656157).

Mouse (Murine) Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

1. High RIPK1 expression is associated with Alzheimer's disease.

2. The authors report here that male reproductive organs of both Ripk3 (zeige RIPK3 Proteine)- and Mlkl-knockout mice retain 'youthful' morphology and function into advanced age, while those of age-matched wild-type mice deteriorate. Feeding of wild-type mice with an RIPK1 inhibitor prior to the normal onset of age-related changes in their reproductive organs blocked the appearance of signs of aging.

3. Pull down experiments with biotinylated Sorafenib show that it binds independently RIPK1, RIPK3 (zeige RIPK3 Proteine) and MLKL. Moreover, it inhibits RIPK1 and RIPK3 (zeige RIPK3 Proteine) kinase activity. In vivo Sorafenib protects against TNF (zeige TNF Proteine)-induced systemic inflammatory response syndrome (SIRS) and renal ischemia-reperfusion injury (IRI).

4. The study provides genetic evidence that different RIP1 kinase inactive mutations have distinct impacts on the embryogenesis of Fadd-deficient mice.

5. Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF (zeige TNF Proteine) and downstream kinases such as RIPK1.

6. TNFalpha (zeige TNF Proteine)-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 (zeige NR2C2 Proteine) plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis.

7. K45 mediated kinase activity of RIPK1 is not only important for necroptosis but it also has a key role in promoting cytokine signaling and host response to inflammatory stimuli.

8. Data show that the kinase activity of receptor-interacting protein kinase (zeige CDK7 Proteine) 1 (RIPK1) is required for Yersinia-induced apoptosis.

9. p38MAPK (zeige MAPK14 Proteine)/MK2 (zeige KCNA2 Proteine) phosphorylation of RIPK1 is a crucial checkpoint for cell fate in inflammation and infection that determines the outcome of bacteria-host cell interaction.

10. MK2 (zeige KCNA2 Proteine)-mediated RIPK1 phosphorylation is an important molecular mechanism limiting the sensitivity of the cells to the cytotoxic effects of TNF (zeige TNF Proteine).

Xenopus laevis Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

1. Interaction of xFADD and xRIP1 induced synergistic activation of JNK (zeige MAPK8 Proteine) and NF-kappaB (zeige NFKB1 Proteine).