anti-KHDRBS1 (KHDRBS1) Antikörper

Bezeichnung:: anti-KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Antikörper (KHDRBS1)

Auf www.antikoerper-online.de finden Sie aktuell 131 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen KHDRBS1 Kits (11) und KHDRBS1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 164 KHDRBS1 Produkte verfügbar.

Synonyme:: fj90g10, KHDRBS1, P62, p68, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	KHDRBS1	10657	Q07666
	KHDRBS1	20218	Q60749
	KHDRBS1	117268	Q91V33
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-KHDRBS1 Antikörper

Autophagie

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Am meisten referenzierte anti-KHDRBS1 Antikörper

Human Polyclonal KHDRBS1 Primary Antibody für ICC, IF - ABIN4351941 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)
Show all 2 Pubmed References

Weitere Antikörper gegen KHDRBS1 Interaktionspartner

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Interaktionspartner

SAM68 is required for efficient recruitment of PUM2 (zeige PUM2 Antikörper) to NORAD, regulation of Pum (zeige MYOD1 Antikörper) activity by NORAD, and proper chromosome segregation in mammalian cells.
Results revealed that upregulation of Sam68 significantly inhibited cisplatin-induced apoptosis in oral tongue squamous cell carcinoma cells.
The PRMT2 (zeige PRMT2 Antikörper) interacts with SAM68 in cells and regulates its subcellular localization via the SH3 domain (zeige ITSN1 Antikörper) of PRMT2 (zeige PRMT2 Antikörper), prompting us to investigate the potential role of PRMT2 (zeige PRMT2 Antikörper) in BCL-X (zeige BCL2L1 Antikörper) alternative splicing.
Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 is a possible trans-acting factor that binds to this cis-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 = GAP-associated tyrosine phosphoprotein p62)
our results indicated that Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-kappaB (zeige NFKB1 Antikörper) activation in ulcerative colitis
Sam68 possibly participated in the progresses of T-acute lymphoblastic leukemia at least partially via AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway
Sam68 is essential for DNA damage-induced NF-kappaB (zeige NFKB1 Antikörper) activation and colon tumorigenesis.
These findings define a hitherto novel mechanism of action for Sam68 in governing p53 (zeige TP53 Antikörper) transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities.
HNRNPL (zeige HNRNPL Antikörper) acts as the adaptor to combine the two substructures and form the intact Sam68 nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures.
Sam68 was overexpressed in EOC tissue in association with such cancer malignant factors of FIGO stage, histological grade, and lymph node metastasis, and also positively regulated the proliferation of EOC cells.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Interaktionspartner

Sam68-haploinsufficiency significantly delayed the onset of tumors in mice lacking p53 (zeige TP53 Antikörper) and prolonged their survival, indicating that Sam68 accelerates the development of p53 (zeige TP53 Antikörper)-deficient tumors.
Sam68 deletion diminishes gamma-irradiation-triggered PAR (zeige AFG3L2 Antikörper) synthesis and NF-kappaB (zeige NFKB1 Antikörper) activation in colon epithelial cells (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs to undergo apoptosis in mice post whole-body gamma-irradiation (WBIR).
This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 (zeige ALDH1A3 Antikörper) expression and maintenance of high glycolytic metabolism in the developing cortex.
our results indicated that Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-kappaB (zeige NFKB1 Antikörper) activation in ulcerative colitis
Sam68 may function as an immune rheostat that balances the activation of NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige NFkBP65 Antikörper) and c-Rel (zeige NFkBP65 Antikörper), as well as MAPK (zeige MAPK1 Antikörper), revealing a potential novel target to manipulate TLR signaling.
Sam68 plays a crucial role in DNA damage response via regulating DNA damage-initiated PAR (zeige AFG3L2 Antikörper) production.
Sam68 is essential for DNA damage-induced NF-kappaB (zeige NFKB1 Antikörper) activation and colon tumorigenesis.
Sam68 and T-STAR (zeige KHDRBS3 Antikörper) could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.
SAM68 is a physiological regulator of SMN2 (zeige SMN1 Antikörper) splicing in a spinal muscular atrophy mouse model.
Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

KHDRBS1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with KHDRBS1

KH RNA binding domain containing, signal transduction associated 1 (KHDRBS1) Antikörper
KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a) Antikörper
KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1) Antikörper
KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1) Antikörper
KH RNA binding domain containing, signal transduction associated 1 (Khdrbs1) Antikörper
KH domain containing, RNA binding, signal transduction associated 1 S homeolog (khdrbs1.S) Antikörper

fj90g10 Antikörper
KHDRBS1 Antikörper
P62 Antikörper
p68 Antikörper
Sam68 Antikörper
wu:fa18g12 Antikörper
wu:fa56c01 Antikörper
wu:fc91b01 Antikörper
wu:fj90g10 Antikörper
zgc:113899 Antikörper

Bezeichner auf Proteinebene für KHDRBS1

GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , sam68 , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68

GENE ID	SPEZIES
10657	Homo sapiens
30082	Danio rerio
374071	Gallus gallus
456705	Pan troglodytes
487316	Canis lupus familiaris
538775	Bos taurus
549799	Xenopus (Silurana) tropicalis
100025483	Monodelphis domestica
20218	Mus musculus
117268	Rattus norvegicus
398660	Xenopus laevis
100725478	Cavia porcellus

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Show all anti-KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antikörper with Pubmed References

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Interaktionspartner

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with KHDRBS1

Bezeichner auf Proteinebene für KHDRBS1