KHDRBS1 Antikörper (C-Term)
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- Target Alle KHDRBS1 Antikörper anzeigen
- KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser KHDRBS1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Spezifität
- KHDRBS1 Antibody detects endogenous levels of total KHDRBS1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human KHDRBS1, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product KHDRBS1 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))
- Andere Bezeichnung
- KHDRBS1 (KHDRBS1 Produkte)
- Synonyme
- Sam68 antikoerper, p62 antikoerper, p68 antikoerper, fj90g10 antikoerper, khdrbs1 antikoerper, wu:fa18g12 antikoerper, wu:fa56c01 antikoerper, wu:fc91b01 antikoerper, wu:fj90g10 antikoerper, zgc:113899 antikoerper, KHDRBS1 antikoerper, P62 antikoerper, khdrbs1l antikoerper, sb:cb97 antikoerper, wu:fb07d11 antikoerper, wu:fi43c05 antikoerper, zgc:85948 antikoerper, KH RNA binding domain containing, signal transduction associated 1 antikoerper, KH domain containing, RNA binding, signal transduction associated 1a antikoerper, KH domain containing, RNA binding, signal transduction associated 1 antikoerper, KH domain containing, RNA binding, signal transduction associated 1 S homeolog antikoerper, KH domain containing, RNA binding, signal transduction associated 1b antikoerper, KHDRBS1 antikoerper, khdrbs1a antikoerper, khdrbs1 antikoerper, Khdrbs1 antikoerper, khdrbs1.S antikoerper, khdrbs1b antikoerper
- Hintergrund
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Description: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).
Gene: KHDRBS1
- Molekulargewicht
- 48 kDa
- Gen-ID
- 10657
- UniProt
- Q07666
- Pathways
- NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie
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