anti-IL1RAP (IL1RAP) Antikörper

Pig (Porcine) Interleukin 1 Receptor Accessory Protein (IL1RAP) Interaktionspartner

1. IL1B (zeige IL1B Antikörper) regulates expression of IL1R1 (zeige IL1RN Antikörper) and IL1RAP and stimulates expression of PTGS1 (zeige PTGS1 Antikörper) and PTGS2 (zeige PTGS2 Antikörper) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (zeige PLIN1 Antikörper)-implantation period of pregnancy in pigs.

Human Interleukin 1 Receptor Accessory Protein (IL1RAP) Interaktionspartner

1. Reconstitution of ST2 (zeige SULT2A1 Antikörper) (IL-1R4) specific for IL-33 (zeige IL33 Antikörper) activity; no suppression by IL-1Ra (zeige IL1RN Antikörper) though a common chain IL-1R3 (IL-1RAcP) shared with IL-1 (zeige IL1A Antikörper).

2. These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells.

3. single nucleotide polymorphism A471T in the Toll (zeige TLR4 Antikörper)-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 (zeige IL1RL2 Antikörper) that is present in approximately 2% of the human population, down-regulated IL-36R (zeige IL1RL2 Antikörper) signaling by a decrease of interaction with IL-1RAcP.

4. The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework.

5. The SNP rs4624606 in IL-1RAcP was nominally associated with CAD (zeige CAD Antikörper) risk.

6. Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis.

7. Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 (zeige SULT2A1 Antikörper) possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution.

8. MARCH8 (zeige MARCH8 Antikörper)-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta (zeige IL1B Antikörper)-induced signaling pathways.

9. Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML (zeige RUNX1 Antikörper) cells.

10. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt (zeige AKT1 Antikörper) kinase.

Mouse (Murine) Interleukin 1 Receptor Accessory Protein (IL1RAP) Interaktionspartner

1. These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1 (zeige IL1RAPL1 Antikörper)/IL-1RAcP.

2. In experimental biliary atresia, miR (zeige MLXIP Antikörper)-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 (zeige IGF1 Antikörper) and Il1RAP are down-regulated by miR (zeige MLXIP Antikörper)-29.

3. The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.

4. IL-1RAcP is essential for physiological activities of peripheral IL-1 (zeige IL1A Antikörper).

5. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

6. data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 (zeige IL1A Antikörper) complex by binding to epitopes on domain III of the IL-1RI created following IL-1 (zeige IL1A Antikörper) binding to the IL-1RI

7. IL-33 (zeige IL33 Antikörper) and ST2 (zeige SULT2A1 Antikörper) form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex.

8. IL-1RAcP is used by more than one alpha-chain (zeige FCGRT Antikörper) of the IL-1 (zeige IL1A Antikörper) receptor family and thus may resemble a common beta-chain (zeige CSF2RB Antikörper) of that family

9. these observations establish AcP (zeige NDUFAB1 Antikörper) as co-receptor for IL-33 (zeige IL33 Antikörper) signaling via ST2 (zeige SULT2A1 Antikörper) and suggest a novel role for sAcP in modulating the biological activity of IL-33 (zeige IL33 Antikörper)

10. an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.