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anti-Human TIAM2 Antikörper:
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Human Polyclonal TIAM2 Primary Antibody für ICC, IF - ABIN4359660
Artym, Swatkoski, Matsumoto, Campbell, Petrie, Dimitriadis, Li, Mueller, Bugge, Gucek, Yamada: Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. in The Journal of cell biology 2015
The authors show that the Rac1 selective guanine nucleotide exchange factor Sif and TIAM1-like Exchange Factor STEF, also known as TIAM2, localises to the nuclear envelope, co-localises with key perinuclear proteins and regulates the activity of perinuclear Rac1.
Tiam2/Rac are key components of EphB2 trans-endocytosis and are important for cell repulsion.
Results provide evidence that Sp1 positively controls TIAM2S transcription and that Sp1-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
Knockdown of TIAM2 could up-regulate the expression of E-cadherin.
TIAM2 expression was undetectable in normal human liver but was induced in all HCC cell lines and in 86% (78/91) of HCC biopsies.
stef gene expressed in a stage- and region-specific manner in the mouse brain
STEF protein is a guanine nucleotide exchange factor that specifically activates Rac1 in vitro and in cultured cells, which may lead to changes in the actin cytoskeletal network.
Tiam2 is expressed in two isoforms, the full-length (Tiam2l) and a short transcript (Tiam2s). Tiam2s expression from the t-allele is strongly increased compared to the wild-type allele. By transgenic approaches we show that Tiam2s enhances t-haplotype transmission, while Tiam2l has the opposite effect.
specificity of PDZ domain and the molecular origin
The findings suggest a new role for STEF in Focal adhesion disassembly and cell migration through microtubules-mediated mechanisms.
Crystal structures of the PH-CC-Ex regions revealed a single globular domain, PHCCEx domain, comprising a conventional PH subdomain associated with an antiparallel coiled coil of CC subdomain and a novel three-helical globular Ex subdomain.
STEF is an activator of cortical neuronal migration.
Extracellular and intracellular information is integrated by STEF to modulate the balance of Rho GTPase activities in the growth cone and control growth cone behavior.
Phosphorylation of STEF by Rho-kinase exerts the inhibitory effect on the function of STEF.
Results describe the purification, crystallization and X-ray data collection of the Tiam1 and Tiam2 PH-CC-Ex regions.
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
SIF and TIAM1-like exchange factor
, T-lymphoma invasion and metastasis-inducing protein 2
, RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, T-cell lymphoma invasion and metastasis 2
, T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, T-lymphoma invasion and metastasis-inducing protein 2-like