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anti-Human PCSK6 Antikörper:
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Human Polyclonal PCSK6 Primary Antibody für ELISA - ABIN316340
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Human Polyclonal PCSK6 Primary Antibody für IHC (p) - ABIN2476044
Gensberg, Jan, Matthews: Subtilisin-related serine proteases in the mammalian constitutive secretory pathway. in Seminars in cell & developmental biology 1998
Show all 2 Pubmed References
Human Polyclonal PCSK6 Primary Antibody für IHC, IHC (p) - ABIN4343356
Perisic, Hedin, Razuvaev, Lengquist, Osterholm, Folkersen, Gillgren, Paulsson-Berne, Ponten, Odeberg, Hedin: Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2013
Human Polyclonal PCSK6 Primary Antibody für ELISA, WB - ABIN562089
Klee, Finlay, McDonald, Attewell, Hebrink, Dyer, Love, Vasmatzis, Li, Beechem, Klee: Bioinformatics methods for prioritizing serum biomarker candidates. in Clinical chemistry 2007
Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6)
Our results suggest that PACE4 is a promising target for estrogen-receptor-positive breast cancer.
PACE4 pre-mRNA undergoes DNA methylation-sensitive alternative splicing of its terminal exon 3' untranslated region, generating an oncogenic, C-terminally modified isoform (PACE4-altCT).
Results provide evidence for the role of PCSK6 as candidate for involvement in the biological mechanisms that underlie the establishment of normal brain lateralization and thus handedness and support the assumption that the degree of handedness, instead the direction, may be the more appropriate indicator of cerebral organization.
Variants in non-coding sequences of PCSK6 gene is associated with handedness.
These results implicate PCSK6 in mediation of brain developmental pathways that jointly impact upon handedness, autism and aspects of schizotypy
In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways
PACE4-knockdown associated growth deficiencies were established on the knockdown HepG2, Huh7, and HT1080 cells as well as the antiproliferative effects of the multi-Leu peptide supporting the growth capabilities of PACE4 in cancer cells.
identified a PCSK6 mutation that impaired corin activation activity in a hypertensive patient
PCSK6 is upregulated in the synovial tissues of patients with rheumatoid arthritis and has a genetic effect on the risk of rheumatoid arthritis. Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.
PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A and TGFbeta2.
miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
PCSK6 was detected at increased levels in the fibrous cap of symptomatic carotid plaques, possibly associated with key processes in plaque rupture such as inflammation and extracellular matrix remodeling.
PACE4 has a distinct role in maintaining proliferation and tumor progression in prostate cancer.
A variant in PCSK6 is strongly associated with protection against pain in knee osteoarthritis.
PCSK6 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas.
In a genome-wide association study of handedness in patients with dyslexia, PCSK6 was the most highly associated marker.
a unique SPC family protease that anchors heparan sulfate proteoglycans at the extracellular matrix; distribution in human placenta
reduction of PACE4 expression in ovarian cancer cells is caused, in part, by DNA hypermethylation and histone deacetylation
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
Mice overexpressing PACE4 exhibited tumors of increased growth rate.
PACE4 participates in bone formation at least in osteoblast differentiation, and estrogen receptor-mediated stimuli induce osteoblast differentiation through the upregulation of PACE4 expression
we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 transgenic mice.
Furin and Pace4 are released by the extraembryonic microenvironment, and that they cleave a membrane-bound reporter substrate in adjacent epiblast cells and activate Nodal to maintain pluripotency
PCSK6 activity plays a role in maintaining normal cellular and tissue homeostasis in the ovary.
PACE4, together with other proprotein convertases, are suitable targets to slow down or block tumor progression.
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4
Spc4 regulates Nodal signalling during gastrulation
plays an important role in the processes of stromal cell decidualization and embryo implantation
the CRD of PC5A and PACE4 functions as a cell surface anchor favoring the processing of their cognate surface-anchored substrates, including endothelial lipase.
The effects of FSH and oocytes on the expression of Pcsk6 mRNA during the the preantral to antral follicle transition are reported.
PACE4 mRNA levels increased markedly during differentiation of skeletal myoblast cell line; results suggest PACE4 plays an important role in myogenic differentiation through association with the IGF-II pathway
maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature Transforming Growth Factor beta proteins in specific sites
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
proprotein convertase PACE4
, proprotein convertase subtilisin/kexin type 6
, proprotein convertase subtilisin/kexin type 6-like
, paired basic amino acid cleaving enzyme 4
, paired basic amino acid cleaving system 4
, subtilisin-like proprotein convertase 4
, subtilisin/kexin-like protease PACE4
, Subtilisin - like endoprotease
, kexin-like protease PC7A
, subtilisin-like kinase SPC4