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Human Monoclonal GSTM2 Primary Antibody für IF, IHC (p) - ABIN516230
Ashour, Angulo, Andrés, Alelú, González-Corpas, Toledo, Rodríguez-Barbero, López, Sánchez-Chapado, Ropero: A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis. in The Prostate 2014
the methylation status of CpG sites in GFRA1 and GSTM2 may have a role and could be used as potential biomarkers for the screening of rectal cancer
The absence of GSTM1 and GSTT1 genes increases the risk of lung cancer because of radon exposure.
the absence of GSTM1 activity can be compensated for by the overexpression of GSTM2.
demonstrated that the GSTM1 and GSTT1 null genotype may be associated with an increased risk of Hepatocellular carcinoma (HCC) and that individuals having the combination of both defective GST genotypes may be more susceptible to developing HCC
High expression of GSTM1 and GSTM4, along with increased endogenous reduced glutathione levels, help to maintain a more reduced state of cytochrome c which decreases apoptosis thus contributing to methotrexate resistance in human MCF7 breast cancer cells.
GST-M2 exhibited high frequency of promoter hypermethylation in lung cancer cells, CpG hypermethylation abated Sp1 binding to the GST-M2 promoter in lung cancer
it was noted that the alpha-6 helix of GST-C plays a stabilising role in the fold of this domain. By destabilising the conformation of GST-C, an increase in cell translocation efficiency of up to approximately 2-fold was observed.
analysis of active-site residues and modulation of catalytic functions in GST-M2
High GSTM2 is associated with mesenchymal stem-like cells derived from ovarian teratoma.
it is unlikely that glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility.
The structure of helix 6 in the carboxyl-terminal fold is critical to GSTM2-2's inhibitory action on the cardiac ryanodine receptor.
identification of residues capable of driving functional diversification in evolution
dinitrosyl-diglutathionyl-iron complex, a natural carrier of nitric oxide, binds with extraordinary affinity to GSTA1-1, which is explained by molecular modeling and related to molecular evolution
GST-M2 may play an important future role in lowering the incidence of benzo[a]pyrene-diolepoxide-induced DNA damage.
CVD risk was higher in smokers compared to non-smokers with GSTT1-1. No significant associations were observed by GSTM1.
dinitrosyl-diglutathionyl-iron complex bound to Alpha class glutathione S-transferases with extraordinary high affinity in hepatocytes
A significant association was found between oxidative stress GSTM1 deletion and the HMOX-1 long repeat and heart rate variation in response to particulate air pollution.
hGSTM2-2 modifies both cardiac & skeletal ryanodine receptor (RyR) activity when it binds to luminal domain of RyR channel complex. GSTM2-2 can interact with specific luminal sites on RyR complex & interaction is likely to be within pore of RyR channel.
children with variants in GSTM2 (glutathione S-transferase mu 2) were more susceptible to effects of in utero tobacco smoke exposure on lung function
The active center of GSTM2-2 for inhibition of cardiac ryanodine receptors involves the helix6 sequence and is essential for its efficacy.
Gstm2 is highly expressed in the uterine luminal epithelium during preimplantation period and up-regulated by progesterone.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
, GST Yb2
, Glutathione-S-transferase mu type 2 (Yb2)
, Glutathione-S-transferase, mu type 2 (Yb2)
, glutathione S-transferase M2
, glutathione S-transferase Mu 2
, glutathione S-transferase Yb-2
, glutathione S-transferase Yb2 subunit
, GST class-mu 2
, GST, muscle
, S-(hydroxyalkyl)glutathione lyase M2
, glutathione S-alkyltransferase M2
, glutathione S-aralkyltransferase M2
, glutathione S-aryltransferase M2
, glutathione S-transferase 4
, glutathione S-transferase M1
, glutathione S-transferase M2 (muscle)
, GST class-mu
, glutathione S-transferase 2
, glutathione S-transferases CL2
, GST Mu I
, glutathione S-transferase Mu 1
, glutathione transferase
, GST 5-5
, glutathione S-transferase pmGT2
, glutathione-S-transferase, mu 2
, GST class-phi member 4
, glutathione S-transferase IV
, hypothetical protein