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neonatal Fc Receptor Proteine

(neonatal Fc Receptor (FcRn))
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

43 Treffer

FcRn Spezies: Human Wirt: Bacteria Recombinant
Produktnummer ABIN7816356
302,50 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen
 
FcRn Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, Imm, ELISA
Produktnummer ABIN7896127
1.889,00 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
FcRn Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, Imm, ELISA
Produktnummer ABIN7896128
1.889,00 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • ELISA
    • Western Blotting (WB)
    • Immunogen (Imm)
    • Antibody Production (AbP)
    • Standard (STD)
    • Size-exclusion chromatography-High Pressure Liquid Chromatography (SEC-HPLC)
    • Surface Plasmon Resonance (SPR)
    • Activity Assay (AcA)
    • Affinity Measurement (AM)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Functional Studies (Func)
    • Immunoassay (IA)
    • Positive Control (PC)
    • Screening Assay (ScA)
    • Antibody Drug Assay (ADA)
  • Reaktivität
    • Human
    • Mouse
    • Cynomolgus
    • Rat
    • Rhesus Monkey
    • Pig
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Nur ohne Konservierungsmittel
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Human Cells
    • Yeast
    • Bacteria
    • Mammalian Cells
    • Baculovirus infected Insect Cells
    • Wheat germ
  • Bindungsspezifität
    • AA 24-297
    • AA 22-297
    • AA 21-119
    • AA 23-298
    • Extracellular
    • AA 24-365
    • Transcript Variant 2
    • AA 16-289
    • AA 22-301
    • AA 24-290
    • AA 25-292
    • AA 51-160
    • Heterodimer
    • Transcript Variant 1
  • Konjugat
    • His tag
    • His tag,Strep Tag
    • His tag,Strep Tag,AVI tag,Biotin
    • GST tag
    • His-Avi Tag,Biotin
    • Myc-DYKDDDDK Tag
    • Unkonjugiert
    • Biotin,His-Avi Tag
    • His tag,AVI tag,Strep Tag,Biotin
    • His tag,Strep Tag,Biotin
    • His-Avi Tag
    • His-SUMO Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Hersteller
    • antibodies-online
    • ACROBiosystems
    • Signalway
    • OriGene
    • Abeomics
    • CUSABIO
    • ProteoGenix

Aktuelle Publikationen für unsere neonatal Fc Receptor Proteine

Spencer, Goldberg, Pandey, Ordonez, Dufloo, Barnette, Sutton, Henderson, Agnor, Gao, Bruel, Schwartz, Haigwood, Ackerman, Hessell: "Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis." in: Nature communications, Vol. 13, Issue 1, pp. 662, (2022) (PubMed).

Kisalu, Pereira, Ernste, Flores-Garcia, Idris, Asokan, Dillon, MacDonald, Shi, Chen, Pegu, Schön, Zavala, Balazs, Francica, Seder: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).

Asokan, Dias, Liu, Maximova, Ernste, Pegu, McKee, Shi, Chen, Almasri, Promsote, Ambrozak, Gama, Hu, Douek, Todd, Lifson, Fourati, Sekaly, Crowley, Ackerman, Ko, Kilam, Boritz, Liao, Best, Perelson et al.: "Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18754-18763, (2020) (PubMed).

Zhao, Gao, Yu, Li, Zhang, Zhang, Lu, Gao, Guo: "Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses." in: Molecular and cellular endocrinology, Vol. 477, pp. 103-111, (2019) (PubMed).

Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).

Yang, Kim, Seong, Tae, Kwon: "Comparative studies of the serum half-life extension of a protein via site-specific conjugation to a species-matched or -mismatched albumin." in: Biomaterials science, Vol. 6, Issue 8, pp. 2092-2100, (2018) (PubMed).

Kenniston, Taylor, Conley, Cosic, Kopacz, Lindberg, Comeau, Atkins, Bullen, TenHoor, Adelman, Sexton, Edwards, Nixon: "Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody." in: The Journal of biological chemistry, Vol. 292, Issue 42, pp. 17449-17460, (2017) (PubMed).

Zhou, Wang, Tong, Okamoto, Shen, Zaro: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." in: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).

Fan, Neubert: "Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS." in: Analytical chemistry, Vol. 88, Issue 8, pp. 4239-47, (2016) (PubMed).

Deissler, Lang, Lang: "Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor." in: Experimental eye research, Vol. 143, pp. 49-59, (2015) (PubMed).

Aliase für neonatal Fc Receptor Proteine

Fc fragment of IgG receptor and transporter (FCGRT) Proteine
Fc fragment of IgG receptor and transporter (Fcgrt) Proteine
Fc receptor, IgG, alpha chain transporter (Fcgrt) Proteine
alpha-chain Proteine
FCRN Proteine
FcRn Proteine
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