NEDD4 Produkte
(Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))
Kategorien
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
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Ausgewählte NEDD4 Kategorien
NEDD4 Antikörper
High quality antibodies with extensive validation data.
NEDD4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NEDD4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC, ELISA, FACS
Validierungen
- (5)
Kat. Nr.
ABIN3031966
Menge
0.4 mL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN653889
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IF
Validierungen
- (4)
- (3)
Kat. Nr.
ABIN968557
Menge
150 μg
Datenblatt
Datenblatt
Empfohlene NEDD4 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6234773
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene NEDD4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7554693
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7563281
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2727061
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NEDD4 Produkten
: "H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis." in: Nature communications, Vol. 8, pp. 14799, (2017) (PubMed).: "p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN." in: Cell death and differentiation, Vol. 21, Issue 1, pp. 146-60, (2013) (PubMed).
: "Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25990-6, (2001) (PubMed).
: "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+." in: The Journal of biological chemistry, Vol. 274, Issue 18, pp. 12525-30, (1999) (PubMed).
: "The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32329-36, (1998) (PubMed).
: "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases." in: The Journal of biological chemistry, Vol. 272, Issue 24, pp. 15085-92, (1997) (PubMed).
Synonyme und alternative Namen zu NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), neural precursor cell expressed, developmentally down-regulated 4 (Nedd4), CG42279 gene product from transcript CG42279-RJ (Nedd4), E3 ubiquitin-protein ligase Nedd-4 (LOC411723), E3 ubiquitin-protein ligase NEDD4 (LOC100457150), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (nedd4), E3 ubiquitin-protein ligase NEDD4 (LOC100547485), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4), AA959633, AL023035, AU019897, CG7555, CG32184, CG42279, Dmel\\CG42279, Dmel_CG7555, Dmel_CG32184, DNedd4, dNedd4, dNedd4-1, E430025J12Rik, GB16853, mKIAA0093, nedd4, NEDD4, Nedd4, NEDD4-1, Nedd4-1, Nedd4a, RPF1Bezeichner auf Proteinebene für NEDD4
- E3 ubiquitin-protein ligase NEDD4
- NEDD-4
- cell proliferation-inducing gene 53 protein
- neural precursor cell expressed developmentally down-regulated protein 4
- receptor-potentiating factor 1
- neural precursor cell expressed, developmentally down-regulated gene 4
- neural precursor cell expressed, developmentally down-regulated gene 4a
- neural precursor cell expressed, developmentally down-regulted gene 4
- CG42279-PE
- CG42279-PF
- CG42279-PG
- CG42279-PH
- CG42279-PI
- CG42279-PJ
- CG42279-PK
- CG42279-PL
- CG42279-PM
- DNedd4
- Nedd4-PE
- Nedd4-PF
- Nedd4-PG
- Nedd4-PH
- Nedd4-PI
- Nedd4-PJ
- Nedd4-PK
- Nedd4-PL
- Nedd4-PM
- neural precursor cell expressed, developmentally down-regulated 4
- ubiquitin-protein ligase Nedd4
- E3 ubiquitin-protein ligase NEDD4-like
- e3 ubiquitin-protein ligase NEDD4-like
- neural precursor cell expressed, developmentally down-regulated gene 4A
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