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results indicated that MafT is a new member of small Maf proteins and involved in the Nrf2-dependent gene regulation in cellular defense system [MafT]
These results suggest that MAFB and MAFF play critical roles in the antitumor effects of retinoids by regulating the expression of retinoid target genes such as TFPI2 and can be promising for developing therapies to combat HCC invasion.
MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML.
MafF/NFE2 hetrodimers act as weak transcriptional activators, and, in particular, are able to stimulate activity of the GCS1 promoter.
In myometrial cells we observed an important induction by interleukin 1 beta and a weaker upregulation by tumor necrosis factor, whereas interleukin 6 treatment had no effect.
Expression of hMafF or MIP alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP activated transcription efficiently.
Only in the presence of both MIP and hMafF could the nUS2-pLacZi reporter in yeast genome be activated.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs are highly susceptible to oxidative stress. (mafF)
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene.
transcription factor MafF
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog F
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog f
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
, v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
, avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein F
, nuclear b-Zip protein MafF