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results indicated that MafT is a new member of small Maf (zeige MAF Antikörper) proteins and involved in the Nrf2 (zeige NFE2L2 Antikörper)-dependent gene regulation in cellular defense system [MafT]
MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML.
MafF/NFE2 hetrodimers act as weak transcriptional activators, and, in particular, are able to stimulate activity of the GCS1 promoter.
In myometrial cells we observed an important induction by interleukin 1 beta (zeige IL1B Antikörper) and a weaker upregulation by tumor necrosis factor (zeige TNF Antikörper), whereas interleukin 6 (zeige IL6 Antikörper) treatment had no effect.
Expression of hMafF or MIP (zeige TNPO1 Antikörper) alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP (zeige TNPO1 Antikörper) activated transcription efficiently.
Only in the presence of both MIP (zeige TNPO1 Antikörper) and hMafF could the nUS2-pLacZi reporter in yeast genome be activated.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
mafG (zeige Mafg Antikörper)::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs are highly susceptible to oxidative stress. (mafF)
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene.
transcription factor MafF
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog F
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog f
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
, v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
, avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein F
, nuclear b-Zip protein MafF