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anti-Human CXCR7 Antikörper:
anti-Mouse (Murine) CXCR7 Antikörper:
anti-Rat (Rattus) CXCR7 Antikörper:
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Human Monoclonal CXCR7 Primary Antibody für CyTOF, FACS - ABIN4900748
Mühlethaler-Mottet, Liberman, Ascenção, Flahaut, Balmas Bourloud, Yan, Jauquier, Gross, Joseph: The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing. in PLoS ONE 2015
Show all 18 Pubmed References
Cow (Bovine) Polyclonal CXCR7 Primary Antibody für FACS, ICC - ABIN4301378
Choy, Yi, Rao, Tellides, Fox-Talbot, Baldwin, Pober: CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells. in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008
Show all 5 Pubmed References
Human Monoclonal CXCR7 Primary Antibody für FACS - ABIN4895525
Liu, Carson-Walter, Walter: Targeting chemokine receptor CXCR7 inhibits glioma cell proliferation and mobility. in Anticancer research 2014
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Human Monoclonal CXCR7 Primary Antibody für CyTOF, FACS - ABIN4899094
Cabezón, Sintes, Llinàs, Benitez-Ribas: Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. in Immunology letters 2010
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Human Monoclonal CXCR7 Primary Antibody für FACS - ABIN4898504
Berahovich, Zabel, Penfold, Lewén, Wang, Miao, Gan, Pereda, Dias, Slukvin, McGrath, Jaen, Schall: CXCR7 protein is not expressed on human or mouse leukocytes. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal CXCR7 Primary Antibody für FACS, ICC - ABIN441317
Singh, Lokeshwar: The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. in Cancer research 2011
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Mouse (Murine) Polyclonal CXCR7 Primary Antibody für CyTOF, FACS - ABIN4899362
Liu, Liu, Li, Wang, Xue, Ge, Luo: The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. in PLoS ONE 2012
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Human Polyclonal CXCR7 Primary Antibody für ELISA, WB - ABIN4301380
Yates, Knapp, Gosalbez, Lokeshwar, Gomez, Benitez, Ekwenna, Young, Manoharan, Lokeshwar: C-X-C chemokine receptor 7: a functionally associated molecular marker for bladder cancer. in Cancer 2012
Human Monoclonal CXCR7 Primary Antibody für FACS - ABIN4895523
Li, Zhang, Tao, Li, Jin: The role of SDF-1-CXCR4/CXCR7 axis in biological behaviors of adipose tissue-derived mesenchymal stem cells in vitro. in Biochemical and biophysical research communications 2013
Human Monoclonal CXCR7 Primary Antibody für FACS - ABIN4898506
Simonetti, Carette, Silva, Wang, De Silva, Heise, Siebel, Shlomchik, Klein: IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. in The Journal of experimental medicine 2013
These findings identify a feed-forward mechanism that sustains activation of the CXCR7/CXCL11 axis under ERalpha control to induce the epithelial-mesenchymal transition pathway and metastatic behavior of ovarian cancer cells.
Upregulation of CXCR7 is associated with Angiogenesis in Degenerated Discs.
the present study demonstrated that expression of CXCR7 in the lung is up-regulated during inflamed conditions and that engagement of CXCR7 with CXCL12 triggers signal transduction and regulates gene expression.
The results of this study indicate that CXCR7 plays an important role in gastric cancer progression via inflammatory mechanisms, suggesting that CXCR7 could provide a basis for the development and clinical application of a targeted drug for gastric cancer.
this study indicated that CXCL12, CXCR4, and CXCR7 were differentially expressed and regulated in u-THP-1 and d-THP-1 cells in response to external stimuli. Importantly, we reported here a novel observation that uncoupling exists between transcriptional and translational regulation of CXCR4, 7 expressions by differentiation and TLR stimuli.
CXCL12-stimulated CXCR7 acts as a functional receptor to activate Akt for angiogenesis in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration and repair after vascular injury.
High CXCR7 expression promotes chemoresistance in esophageal squamous cell carcinoma.
his study uncovered a novel mechanism of colorectal tumorigenesis through the CXCR7/CXCR4 heterodimer-induced histone demethylation. Inhibition of CXCR7/CXCR4 heterodimer-induced histone demethylation could be an effective strategy for the prevention and treatment of colorectal cancer.
this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12.
Expression of CXCR7 associates with increased survival in CXCR4+ but not in CXCR4- DLBCL patients. CXCR7 overexpression in vitro is able to diminish DLBCL cell survival and increase their sensitivity to antitumor drugs.
Residues 2-6 of ACKR3 form an antiparallel beta-sheet with the beta1 strand (residues 25-29) of CXCL12.
These findings suggest that the manipulation of miR-539-5p/CXCR7 levels may have important therapeutic implications in choroidal neovascularization-associated diseases
CXCR7 is an oncogene in PCa that can promote aggressive progression of PCa through enhancing proliferation and migration of the tumor cells.
Study shows that overexpression of CXCR7 in different cellular populations of endometriosis microenvironment may play a role in the pathogenesis and represent a novel target for treatment.
CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.
Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function
This work demonstrates distinct roles for the SDF-1/CXCR4 or CXCR7 network in human induced pluripotent stem cell-derived ventricular cardiomyocyte specification, maturation and function.
A role for CXCR7 in bladder cancer [review]
CXCR7-small hairpin RNA inhibits tumour invasion and metastasis.
Chemokine receptor CXCR7 may involve in the clinical glioblastoma (GBM) progression, and CXCR7 could be a valuable prognostic marker in the treatment of GBM.
CXCR7 serves as Dkk3 receptor, which mediates Dkk3-induced vascular progenitor migration in vitro and in tissue-engineered vessels.
CXCL14 is expressed by islet delta-cells where it may have paracrine effects to inhibit insulin secretion in a CXCR4/CXCR7-independent manner through reductions in beta-cell ATP levels.
CXCR7 gene overexpression promoted mesenchymal stem cell proliferation and migration, whereas suppressing CXCR7 had the opposite effect.
the Sdf-1 receptors - Cxcr4 and Cxcr7, as well as signaling pathways induced by these molecules in primary myoblasts, as well as various stem cells, were studied.
the pivotal role of CXCR4- and CXCR7-inhibition in acute pulmonary inflammation, which depended on A2B-receptor signaling, is reported.
endothelial CXCR7+ cells regulate CXCL12 gradient direction by controlling concentrations near but not far from the vasculature.
High CXCR7 expression is associated with Prostate Cancer.
the data identified the pivotal role of the receptor CXCR7 in pulmonary inflammation with a predominant effect on the pulmonary epithelium and polymorphonuclear neutrophils
CXCR7 expression in adipose tissue macrophages is upregulated in obesity.
Elevated expression of CXCR7 enhances endothelial progenitor cell resistance to diabetes mellitus-induced oxidative damage.
expression of CXCR7 in normal and pathological nervous system suggests CXCR4-independent functions of SDF-1/CXCL12 mediated through its interaction with CXCR7
confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development
our present study provided evidence that SDF-1 mediated CSCs migration through CXCR4 and CXCR7 via MEK/ERK and PI3K/Akt pathway
Endothelial CXCR7 limits breast cancer metastasis at multiple steps in the metastatic cascade, advancing understanding of CXCL12 pathways in tumor environments and informing ongoing drug development targeting CXCR7 in cancer.
Sata demonstrate that CXCR7 has a role in the positioning of hem and pallium-subpallium boundary-derived Cajal-Retzius (CR)cells, CXCL12 regulating CR cell subpial localization through the combined action of CXCR4 and CXCR7.
CXCR7 acts to prevent epithelial damage and ameliorate fibrosis after a single lung injury, repeated injury leads to suppression of CXCR7 expression and recruitment of VEGFR1 expressing macrophages, Wnt and Notch signaling, and enhanced fibrosis.
CXCR7 overexpression in MSCs reversed the inhibitory effect of high concentrations of SDF-1alpha.
Collectively, our data demonstrate that CXCR7 suppression modulates microglial chemotaxis to ameliorate EAE.
Both CXCR7 and Rac1 are required for extracellular signal-regulated kinases (ERK) 1/2 activation and subsequent NPC migration, indicating that CXCR7 could serve as a functional receptor in CXCL12-mediated NPC migration independent of CXCR4.
expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
C-X-C chemokine receptor type 7
, G protein-coupled receptor
, G-protein coupled receptor 159
, G-protein coupled receptor RDC1 homolog
, chemokine (C-X-C motif) receptor 7
, chemokine orphan receptor 1
, G protein coupled receptor
, G-protein coupled receptor RDC1
, RDC1-like G protein-coupled receptor
, RDC1 like protein
, atypical chemokine receptor 3 L homeolog
, atypical chemokine receptor 3