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Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.
Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.
Altering TR4 (zeige NR2C2 ELISA Kits)-ATF3 signaling increases the efficacy of cisplatin to suppress hepatocellular carcinoma growth/progression.
ATF3 may be a potential early diagnostic biomarker for silicosis and ATF3 acts as a repressor in inflammatory responses induced by silica
The analysis showed higher urinary NGAL (zeige LCN2 ELISA Kits) and urinary ATF3 in patients with sepsis-AKI in comparison with patients with sepsis-non-AKI and healthy volunteers.
ATF3 mRNA and protein expression was significantly reduced in preterm Preeclamptic placentas. Therefore, reduced ATF3 may be centrally involved in the pathology of Preeclampsia.
Data suggest that suppression of nonsense-mediated RNA decay due to persistent DNA damage (from exposure to either mutagens, gamma rays, or oxidative stress) requires the activity of p38alpha (zeige MAPK14 ELISA Kits) MAPK (zeige MAPK1 ELISA Kits) (MAPK14 (zeige MAPK14 ELISA Kits), mitogen-activated protein kinase 14 (zeige MAPK14 ELISA Kits), MAP kinase p38 alpha (zeige MAPK14 ELISA Kits)); mRNA of ATF3 (activating transcription factor 3) is stabilized by persistent DNA damage in a p38alpha (zeige MAPK14 ELISA Kits) MAPK (zeige MAPK1 ELISA Kits)-dependent manner.
The microvascular injury phenotypes observed in vitro and in vivo were similar. ATF3 plays an important role in mediating brain microvascular responses to acute and chronic lipotoxic injury and may be an important preventative and therapeutic target for endothelial dysfunction in vascular cognitive impairment .
we have identified ATF3 as an important regulator of cisplatin cytotoxicity and that ATF3 inducers in combination with platins are a potential novel therapeutic approach for NSCLC.
reactivation of ATF3 is an important factor in determining sensitivity to pracinostat treatment, both in vitro and in vivo, and could serve as a potential biomarker of response and provide a rationale for therapeutic utility in HDACi-mediated treatments for bladder cancer.
these findings support roles for both cFOS (indirect) and ATF3 (direct) in effecting MMP13 (zeige MMP13 ELISA Kits) transcription in human chondrocytes.
We functionally validated several elements for metformin-induced promoter and enhancer activity. These include an enhancer in an ataxia telangiectasia mutated (ATM (zeige ATM ELISA Kits)) intron that has SNPs in linkage disequilibrium .Using ChIP-seq and siRNA knockdown, we further show that activating transcription factor 3 (ATF3), our top metformin upregulated AMPK (zeige PRKAA1 ELISA Kits)-dependent gene, could have an important role in gluconeogenesis repression.
The different anti-inflammatory mechanisms of the ApoA-I (zeige APOA1 ELISA Kits) cysteine mutants might be associated with the regulation of ATF3 level.
ATF3 is a new co-factor of c-Fos and NFATc1 (zeige NFATC1 ELISA Kits) to activate osteoclast differentiation and activity.
This study shows, for the first time, that alpha-lactalbumin (zeige LALBA ELISA Kits) isolated in a rare 28kDa dimeric form induces cell death, while 14kDa (zeige SRP14 ELISA Kits) monomeric alpha-lactalbumin (zeige LALBA ELISA Kits) is inactive.
Results show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding regeneration-associated gene cluster.
Results reveal a critical role for ATF3 as a key regulator of the acinar cell transcriptional response during injury and may provide a link between chronic pancreatitis and PDAC.
The lung injury score and mortality were higher in ATF3 knock-out mice treated with Pseudomonas aeruginosa. Moreover, ATF3 was demonstrated to bind to lipopolysaccharide binding protein (zeige LBP ELISA Kits). These findings suggest ATF3 protects mice against acute lung injury induced by Pseudomonas aeruginosa partly due to the binding to lipopolysaccharide binding protein (zeige LBP ELISA Kits).
ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (zeige CXCL10 ELISA Kits)-CXCR3 (zeige CXCR3 ELISA Kits) axis at multiple levels.
ATF3 has a protective role in dampening the high fat-induced cardiac remodeling processes.
ATF3 protects against LPS (zeige TLR4 ELISA Kits)-induced acute lung injury by inhibiting TL1A (zeige TNFSF15 ELISA Kits) expression.
Myotube contraction increased ATF3 level, which modified chemokine (zeige CCL1 ELISA Kits) expression. In skeletal muscle after downhill running, ATF3 also modified chemokine (zeige CCL1 ELISA Kits) expression.
ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (zeige MAPK8 ELISA Kits) pathway in endothelial cells
Data indicate increasing expression for CREB (zeige CREB1 ELISA Kits), ATF1 (zeige AFT1 ELISA Kits), and ATF3 during gastrulation.
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
cyclic AMP-dependent transcription factor ATF-3
, activating transcription factor 3
, cAMP-dependent transcription factor ATF-3
, transcription factor LRG-21
, liver regeneration factor 1