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anti-Human CYP4F2 Antikörper:
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Human Polyclonal CYP4F2 Primary Antibody für IHC, IHC (p) - ABIN4301783
Alexanian, Miller, Roman, Sorokin: 20-HETE-producing enzymes are up-regulated in human cancers. in Cancer genomics & proteomics 2012
The allele frequency, haplotype distribution, new genetic variants and linkage disequilibrium of CYP4F2 in Koreans.
Epistatic interactions associated with susceptibility to coronary artery disease were found between rs9332978 of CYP4A11 and rs1558139 of CYP4F2.
The C/T genotype of the CYP4AF2 rs1558139 polymorphism might serve as a protective factor for male patients with hypertension in Asian populations, and CYP4AF2 rs2108622 may confer reduced genetic susceptibility to coronary heart disease.
Data suggests that expression of CYP4F2 is down-regulated in liver of mice with non-alcoholic fatty liver disease after high-fat/Western diet and in human hepatocyte cell line exposed to excess palmitic acid, oleic acid, or fructose. Two other genes are down-regulated, PPAR gamma and SREBP-1. (PPAR = peroxisome proliferator-activated receptor; SREBP-1 = sterol regulatory element-binding protein-1)
show that children on chronic warfarin therapy have low levels of vitamin K and vitamin K levels are linked to CYP4F2 genotype
impact of CYP4F2, ABCB1, and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
CYP4F2 gene repression and a sustained vitamin E metabolism appear to be independent effects of ethanol toxicity in human hepatocytes
CYP4A1l rs9333025 GG and CYP4F2 rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level.
This study provides data on VKORC1 and CYP4F2 variants among an indigenous Ghanaian population.
This meta-analysis indicated the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation in coumarin-treated patients failed to reach the level of statistical significance.
Did not find any association of the CYP4F2 gene rs2108622 polymorphism with hypertension.
Study showed that the V433M polymorphism in CYP4F2, responsible for epoxyeicosatrienoic acids synthesis, was an independent risk factor for post-transplant diabetes mellitus.
Bearing of two minor alleles of CYP4F2 missense variant modestly explains inter-ethnic differences of studied populations. CYP4F2*3 risk allele frequency of Roma was in higher range, and of Hungarians in lower range, compared with other world populations
CYP4F2 c.1297A polymorphism has a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe.
The frequency of CYP2C9, CYP4F2, and VKORC1 polymorphisms in Russian patients with thrombosis is comparable with other European ethnic groups.
To evaluate the associations between four single-nucleotide polymorphisms (SNPs) in CYP4A11 and CYP4F2 and ischemic stroke (IS)
Plasma VK1 and MK-4 concentrations are influenced by CYP4F2 genetic polymorphism but not associated with warfarin therapy in Japanese patients. CYP4F2 polymorphism is poorly associated with inter-individual variability of warfarin dosage requirement.
CYP4F2 gene polymorphism might increase the risk of ischemic stroke in the Chinese population.
Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained : VKORC1 genotype accounted for 29.6%, CYP2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4alpha (rs2501873/rs3212198) for 1.7%
Although initial studies on CYP4F2 were focused on its role as a regulator of LTB4 and 20-HETE, current investigations focus on how variants of CYP4F2 affect warfarin drug dosing and safety
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
leukotriene-B(4) omega-hydroxylase 1
, cytochrome P450 4F2
, cytochrome P450-LTB-omega
, leukotriene-B4 20-monooxygenase
, leukotriene B4 omega-hydroxylase
, leukotriene-B(4) 20-monooxygenase 1
, cytochrome P450, subfamily IVF, polypeptide 2
, cytochrome P450, family 4, subfamily F, polypeptide 2