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Human Polyclonal CYP4F2 Primary Antibody für IHC, IHC (p) - ABIN4301783
Alexanian, Miller, Roman, Sorokin: 20-HETE-producing enzymes are up-regulated in human cancers. in Cancer genomics & proteomics 2012
Data suggests that expression of CYP4F2 is down-regulated in liver of mice with non-alcoholic fatty liver disease after high-fat/Western diet and in human hepatocyte cell line exposed to excess palmitic acid, oleic acid, or fructose. Two other genes are down-regulated, PPAR gamma (zeige PPARG Antikörper) and SREBP-1 (zeige SREBF1 Antikörper). (PPAR (zeige PPARA Antikörper) = peroxisome proliferator-activated receptor (zeige PPARD Antikörper); SREBP-1 (zeige SREBF1 Antikörper) = sterol regulatory element-binding protein-1 (zeige SREBF1 Antikörper))
show that children on chronic warfarin therapy have low levels of vitamin K and vitamin K levels are linked to CYP4F2 genotype
impact of CYP4F2, ABCB1 (zeige ABCB1 Antikörper), and GGCX (zeige GGCX Antikörper) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
CYP4F2 gene repression and a sustained vitamin E metabolism appear to be independent effects of ethanol toxicity in human hepatocytes
CYP4A1l rs9333025 GG and CYP4F2 rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level.
This study provides data on VKORC1 (zeige VKORC1 Antikörper) and CYP4F2 variants among an indigenous Ghanaian population.
This meta-analysis indicated the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation in coumarin-treated patients failed to reach the level of statistical significance.
Did not find any association of the CYP4F2 gene rs2108622 polymorphism with hypertension.
Study showed that the V433M polymorphism in CYP4F2, responsible for epoxyeicosatrienoic acids synthesis, was an independent risk factor for post-transplant diabetes mellitus.
Bearing of two minor alleles of CYP4F2 missense variant modestly explains inter-ethnic differences of studied populations. CYP4F2*3 risk allele frequency of Roma was in higher range, and of Hungarians in lower range, compared with other world populations
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
leukotriene-B(4) omega-hydroxylase 1
, cytochrome P450 4F2
, cytochrome P450-LTB-omega
, leukotriene-B4 20-monooxygenase
, leukotriene B4 omega-hydroxylase
, leukotriene-B(4) 20-monooxygenase 1
, cytochrome P450, subfamily IVF, polypeptide 2
, cytochrome P450, family 4, subfamily F, polypeptide 2