anti-Abcd2 (Abcd2) Antikörper

Bezeichnung:: anti-ATP-Binding Cassette, Sub-Family D (ALD), Member 2 Antikörper (Abcd2)

Auf www.antikoerper-online.de finden Sie aktuell 25 ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Antikörper von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 29 Abcd2 Produkte verfügbar.

Synonyme:: ABC39, ALDL1, ALDR, ALDRP, DDBDRAFT_0214891, DDBDRAFT_0219834, DDB_0214891, DDB_0219834, hALDR

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	Abcd2	225	Q9UBJ2
	Abcd2	26874	Q61285
	Abcd2	84356	Q9QY44
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human Abcd2 Antikörper:

anti-Mouse (Murine) Abcd2 Antikörper:

anti-Rat (Rattus) Abcd2 Antikörper:

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Verknüpfte Pathways mit anti-Abcd2 Antikörper

Monocarboxylic Acid Catabolic Process

Weitere Antikörper gegen Abcd2 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Interaktionspartner

ABCD1 (zeige ABCD1 Antikörper) and ABCD2 are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 (zeige ABCD3 Antikörper) is involved in the transport of branched chain acyl-CoA (zeige GNPAT Antikörper) into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 (zeige NDUFB3 Antikörper) from lysosomes into the cytosol.
13-cis (zeige CISH Antikörper)-retinoic acid induces ABCD2 expression in human monocytes/macrophages.
ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack
results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA
The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin (zeige CTNNB1 Antikörper) and TCF-4 (zeige TCF4 Antikörper).
LXRalpha (zeige NR1H3 Antikörper) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (zeige NR1H3 Antikörper) binding sites
Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.
These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy.
LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19 (zeige PEX19 Antikörper). This interaction is mediated by amino acids 1-218 of ALDRP.
ALDRP interacts with PMP70 (zeige ABCD3 Antikörper). This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 (zeige ABCD3 Antikörper) C-terminus [338-659]. This interaction was demonstrated using human PMP70 (zeige ABCD3 Antikörper) and mouse ALDRP.

Mouse (Murine) ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Interaktionspartner

ABCD1 (zeige ABCD1 Antikörper) and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1 (zeige ABCD1 Antikörper)-deficient mice
The absence of ABCD2 altered expression of gene clusters associated with lipid metabolism, including PPARalpha (zeige PPARA Antikörper) signaling.
ABCD2 is a sterol regulatory element binding protein (zeige CNBP Antikörper) target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.
Evidence against the adrenoleukodystrophy-related gene acting as a modifier of X-adrenoleukodystrophy.
LXRalpha (zeige NR1H3 Antikörper) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (zeige NR1H3 Antikörper) binding sites
Abcd1 (zeige ABCD1 Antikörper) and Abcd2 gene silencing sensitizes astrocytes for inflammation and may have a role in X-adrenoleukodystrophy
ABCD2 plays a role in th degradation of long-chain saturated and omega9-monounsaturated fatty acids and in the synthesis of docosahexanoic acid.

Abcd2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown\; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Alternative names and synonyms associated with Abcd2

ATP binding cassette subfamily D member 2 (ABCD2) Antikörper
ABC transporter D family protein (abcD2) Antikörper
ATP-binding cassette sub-family D member 2 (LOC100549247) Antikörper
ATP binding cassette subfamily D member 2 (abcd2) Antikörper
ATP-binding cassette sub-family D member 2 (LOC100640478) Antikörper
ATP-binding cassette, sub-family D (ALD), member 2 (Abcd2) Antikörper
ATP binding cassette subfamily D member 2 (Abcd2) Antikörper

ABC39 Antikörper
ALDL1 Antikörper
ALDR Antikörper
ALDRP Antikörper
DDBDRAFT_0214891 Antikörper
DDBDRAFT_0219834 Antikörper
DDB_0214891 Antikörper
DDB_0219834 Antikörper
hALDR Antikörper

Bezeichner auf Proteinebene für Abcd2

ATP-binding cassette, sub-family D, member 2 , ATP-binding cassette, sub-family D (ALD), member 2 , ATP-binding cassette sub-family D member 2 , ATP-binding cassette sub-family D member 2-like , adrenoleukodystrophy-like 1 , adrenoleukodystrophy-related protein , adrenoleukodystrophy related

GENE ID	SPEZIES
466952	Pan troglodytes
477643	Canis lupus familiaris
526436	Bos taurus
8629134	Dictyostelium discoideum AX4
100413459	Callithrix jacchus
100520309	Sus scrofa
417694	Gallus gallus
697556	Macaca mulatta
100019263	Monodelphis domestica
100433322	Pongo abelii
100549247	Meleagris gallopavo
100556516	Anolis carolinensis
100583742	Nomascus leucogenys
100640478	Amphimedon queenslandica
225	Homo sapiens
26874	Mus musculus
84356	Rattus norvegicus

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