(MHC Class I Polypeptide-Related Sequence A (MICA))
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
MICA
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ELISA
Srpan, Ambrose, Karampatzakis, Saeed, Cartwright, Guldevall, De Matos, Önfelt, Davis: "Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells." in: The Journal of cell biology, Vol. 217, Issue 9, pp. 3267-3283, (2018) (PubMed).
Xiang, Liu, Zheng, Liu, Lv, Gao, Hu, Lam, Chan, Yang, Chen, Tsao, Bonneville, Lau, Tu: "Targeted activation of human V?9V?2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease." in: Cancer cell, Vol. 26, Issue 4, pp. 565-76, (2014) (PubMed).
Aliase für MICA Proteine
MHC class I polypeptide-related sequence A (MICA) Proteine MIC-A Proteine PERB11.1 Proteine