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Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (zeige AR Proteine) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (zeige DPT Proteine) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (zeige SREBF2 Proteine) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.
mutations of the SRD5A2 gene are the main causes of posterior hypospadias
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC) with 5alpha-reductase inhibitors (5-ARI).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (zeige ESR1 Proteine)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (zeige SHBG Proteine)). No associations between the previously associated SNPs in the genes ESR1 (zeige ESR1 Proteine) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (zeige INS Proteine) resistance (IR) rather than obesity.
Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)
Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
3-oxo-5-alpha-steroid 4-dehydrogenase 2
, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
, steroid-5-alpha-reductase alpha polypeptide 2
, 5 alpha-SR2
, SR type 2
, steroid 5 alpha reductase type2
, steroid 5-alpha-reductase 2
, S5AR 2
, type II 5-alpha reductase
, prostatic steroid 5-alpha-reductase type II