Mesothelin Proteine
(Mesothelin (MSLN))
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
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MSLN
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 97 %
WB, SDS, Imm, PC
MSLN
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, Imm, PC
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
MSLN
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, Imm, PC
MSLN
Spezies: Human
Wirt: Mammalian Cells
Recombinant
WB, SDS, ELISA
MSLN
Spezies: Human
Wirt: Mammalian Cells
Recombinant
WB, SDS, ELISA
MSLN
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, Imm, PC
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
MSLN
Spezies: Human
Wirt: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Synthetic Nanodisc
ELISA, Imm, cryo-EM, PhD, SPR
custom-made
MSLN
Spezies: Maus
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
MSLN
Spezies: Human
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
MSLN
Spezies: Maus
Wirt: Hefe
Recombinant
> 90 %
SDS
1 image
MSLN
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % , as determined by Coomassie stained SDS-PAGE.
FACS
Active
MSLN
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 95 % , as determined by Coomassie stained SDS-PAGE.
ELISA
Active
MSLN
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %, determined by SDS-PAGE and stained with Commassie blue. (See image below).
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % , as determined by Coomassie stained SDS-PAGE.
AbP, STD, Func, PI
Active
Aktuelle Publikationen für unsere Mesothelin Proteine
: "Preclinical evaluation of a novel anti-mesothelin immunotoxin based on a single domain antibody as the targeting ligand." in: International journal of pharmaceutics, Vol. 602, pp. 120647, (2021) (PubMed).: "Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." in: Biotechnology and bioengineering, (2019) (PubMed).
: "Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding." in: PLoS ONE, Vol. 13, Issue 5, pp. e0197029, (2018) (PubMed).
: "Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways." in: The Biochemical journal, Vol. 442, Issue 2, pp. 293-302, (2012) (PubMed).
: "Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer." in: Molecular cancer therapeutics, Vol. 7, Issue 2, pp. 286-96, (2008) (PubMed).
Aliase für Mesothelin Proteine
mesothelin (MSLN) Proteinemesothelin (Msln) Proteine
mesothelin (LOC611363) Proteine
mesothelin (LOC100524016) Proteine
MPF Proteine
MSLN Proteine
SMRP Proteine
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